Results 61 to 70 of about 28,655 (201)
iMetaOmics, EarlyView.This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang +21 more
wiley +1 more source
Furin‐mediated protein processing in infectious diseases and cancer
Clinical & Translational Immunology, 2019 Proteolytic cleavage regulates numerous processes in health and disease. One key player is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at polybasic recognition motifs.
Elisabeth Braun, Daniel Sauter
doaj +1 more source
Pan-Cancer Analysis of FURIN as a Potential Prognostic and Immunological Biomarker
Frontiers in Molecular Biosciences, 2021 BackgroundFurin is a calcium-dependent protease that processes various precursor proteins through diverse secretory pathways. The deregulation of FURIN correlated with the prognosis of patients in numerous diseases.
Bolun Zhou, Shugeng Gao
doaj +1 more source
The proprotein convertase furin in tumour progression [PDF]
International Journal of Cancer, 2017 Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. These proteins are generally synthesised as precursor proteins and require limited proteolysis for conversion into their mature bioactive counterparts.
Jaaks, Patricia, Bernasconi, Michele
openaire +3 more sources
iNew Medicine, EarlyView.This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng +3 more
wiley +1 more source
Integrative Zoology, EarlyView.We found that teleosts employed two different strategies to ensure sufficient ZP (zona pellucida) synthesis: expansion of ZPB1(a) and ZPC1(a) in basal species or liver expression of ZPB1a and ZPC1aa in advanced species. The N‐terminus of expanded ZPB1(a) or ZPC1(a) and liver‐expressed ZPB1a contains repeated units or low‐complexity regions to form ...
Tian Gao +8 more
wiley +1 more source
Probable human origin of the SARS-CoV-2 polybasic furin cleavage site [PDF]
, 2022 Antonio R. Romeu
openalex +1 more source
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. [PDF]
PLoS ONE, 2013 Folliculogenesis is tightly controlled by a series of hormones, growth factors and cytokines, many of which are secreted as proproteins and require processing by proteases before becoming functional.
Xiaokui Yang +8 more
doaj +1 more source
Significance of Furin Expression in Thyroid Neoplastic Transformation
Cancers, 2023 Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the
Maria Teresa Azevedo +8 more
openaire +3 more sources