Results 51 to 60 of about 488 (118)

Energetic Azoxy‐Coupled Tetrazoles

Journal of Heterocyclic Chemistry, Volume 61, Issue 11, Page 1704-1709, November 2024.
5‐Amino‐2‐methyl‐tetrazole, above, left, when reacted with Oxone affords a transiently stable nitroso intermediate (blue solution). When the nitroso is reacted to completion, 5,5′‐azoxy‐bis‐2,2′‐methyl‐tetrazole is yielded as yellow rods. For scale reference, the microscope slide the crystals rest on is 22 mm × 22 mm. ABSTRACT Azoxy coupling of 5‐amino‐
Nicholas F. Scherschel, Matthias Zeller, Davin G. Piercey   +2 more
wiley   +1 more source

Tuning Green Explosives through SNAr Chemistry

Chemistry – An Asian Journal, Volume 19, Issue 13, July 2, 2024.
Graphical abstract showing a new concept for tuning the properties of environmentally benign primary explosives based on SNAr click‐chemistry. Abstract Reactivity and regioselectivity of SNAr‐type fluorine substitution with azide in polyfluorosubstituted nitrobenzenes was studied both theoretically and experimentally. The obtained polyazido‐substituted
Sergei Nikitin, Frederik Diness
wiley   +1 more source

Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives

ChemistryOpen, 2020
Fifteen novel furoxan‐based nitric oxide (NO) releasing hybrids of estradiol derivatives were synthesized and evaluated in vitro anti‐proliferative activity in MDA‐MB‐231, A2780, Hela and HUVEC cell lines. Most of them displayed potent anti‐proliferative
Qi Wan, Yan Deng, Yaoqing Huang, Zhihui Yu, Chunli Wang, Ke Wang, Assoc. Prof. Jibin Dong, Prof. Ying Chen   +7 more
doaj   +1 more source

Naphthyl‐Based Chalcone Derivatives: A Multifaceted Player in Medicinal Chemistry

ChemistrySelect, Volume 9, Issue 19, May 21, 2024.
This review insights the pharmacological activity of naphthyl substituted chalcone derivatives. The anticancer and antibacterial activities were more explored than other activities. The presence of methoxy and naphthyl moiety enhanced the anticancer activity. The antibacterial activity was increased by electron withdrawing groups.
Priyanka Mahesha, Nitinkumar S. Shetty
wiley   +1 more source

Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy – A comprehensive review

Food Science &Nutrition, Volume 12, Issue 5, Page 3046-3067, May 2024.
Oridonin (ORI), an ent‐kaurane diterpenoid, naturally found in the leaves of Rabdosia rubescens species, has been found to have antitumor and antiangiogenic properties. It inhibits several cancer‐signaling pathways like NFκB, PI3K, BCL2, BCLX, and p53‐mediated pathways.
Muhammad Asif Ali, Noohela Khan, Ahmad Ali, Hira Akram, Noushaba Zafar, Kinza Imran, Tooba Khan, Khushbukhat Khan, Muhammad Armaghan, Marta Palma‐Morales, Celia Rodríguez‐Pérez, Angela Caunii, Monica Butnariu, Solomon Habtemariam, Javad Sharifi‐Rad   +14 more
wiley   +1 more source

A Novel Melt Cast Composite Booster Formulation Based on DNTF/TNT/GAP-ETPE/Nano-HMX

Journal of Chemistry, 2016
To obtain the melt cast booster explosive formulation with high energy and low critical detonation diameter, melt cast explosives were designed by 3,4-bis(3-nitrofurazan-4-yl)furoxan (DNTF)/2,4,6-trinitrotoluene (TNT)/glycidyl azide polymer-energetic ...
Shuo Yu, Hequn Li
doaj   +1 more source

NO-Releasing Enmein-Type Diterpenoid Derivatives with Selective Antiproliferative Activity and Effects on Apoptosis-Related Proteins

Molecules, 2016
A series of nine enmein-type ent-kaurane diterpenoid and furoxan-based nitric oxide (NO) donor hybrids (10a–i) were designed and synthesized from commercially available oridonin (1).
Dahong Li, Xu Hu, Tong Han, Jie Liao, Wei Xiao, Shengtao Xu, Zhanlin Li, Zhenzhong Wang, Huiming Hua, Jinyi Xu   +9 more
doaj   +1 more source

Bioinspired Lipoproteins of Furoxans–Gemcitabine Preferentially Targets Glioblastoma and Overcomes Radiotherapy Resistance

Advanced Science, Volume 11, Issue 6, February 9, 2024.
Inspired by the aberrant upregulation of DNA‐repairing RAD51, scavenger receptor B type 1 (SR‐B1), and C‐C motif chemokine ligand 5 (CCL5) in GBM patients, a reduction‐sensitive nitric oxide donor conjugate of furoxans–gemcitabine (NG) is rationally synthesized and a CCL5‐modified bioinspired lipoprotein system of C‐LNG is designed, which ...
Maoyuan Sun, Honglei Xie, Wenli Zhang, Xianlu Li, Zhan Jiang, Yiyu Liang, Guanjian Zhao, Ning Huang, Jinning Mao, Guodong Liu, Zhiwen Zhang   +10 more
wiley   +1 more source

Analysis of degradation products in thermally treated TATB

Propellants, Explosives, Pyrotechnics, Volume 49, Issue 2, February 2024.
Abstract Delineating the chemical composition of TATB (1,3,5‐triamino‐2,4,6‐trinitrobenzene) residues produced from the exposure to abnormal thermal environments should lead to a better understanding of the decomposition paths. Identifying and quantifying each compound in thermally produced residues, monitors which compounds are degrading or forming ...
Keith R. Coffee, Adele F. Panasci‐Nott, Jason A. Olivas, John Selinsky, Keith D. Morrison, Alan K. Burnham, Gregory L. Klunder, John G. Reynolds   +7 more
wiley   +1 more source

A surprising new route to 4-nitro-3-phenylisoxazole

Beilstein Journal of Organic Chemistry, 2010
A one-pot synthesis of 4-nitro-3-phenylisoxazole has been carried out by treatment of cinnamyl alcohol dissolved in acetic acid with sodium nitrite; in addition, 4-phenyl-3-furoxanmethanol was obtained in 40% yield.
Henning Hopf, Aboul-fetouh E. Mourad, Peter G. Jones   +2 more
doaj   +1 more source