Results 31 to 40 of about 488 (118)

Synthesis and Modeling Studies of Furoxan Coupled Spiro-Isoquinolino Piperidine Derivatives as NO Releasing PDE 5 Inhibitors

Biomedicines, 2020
Nitric oxide (NO) is considered to be one of the most important intracellular messengers that play an active role as neurotransmitter in regulation of various cardiovascular physiological and pathological processes. Nitric oxide (NO) is a major factor in
Swami Prabhuling, Yasinalli Tamboli, Prafulla B. Choudhari, Manish S. Bhatia, Tapan Kumar Mohanta, Ahmed Al-Harrasi, Zubaidha K. Pudukulathan   +6 more
doaj   +1 more source

Inverse Design of Singlet‐Fission Materials with Uncertainty‐Controlled Genetic Optimization

Angewandte Chemie, Volume 137, Issue 3, January 15, 2025.
We uncover candidates for singlet fission using a machine learning‐driven uncertainty‐controlled genetic algorithm (ucGA), which is run either in an exploitative or explorative manner. Leveraging a fragment database (reFORMED) derived from crystal structure data, we propose a class of heteroatom‐rich mesoionic compounds as acceptors for charge‐transfer
Luca Schaufelberger, J. Terence Blaskovits, Ruben Laplaza, Kjell Jorner, Clemence Corminboeuf   +4 more
wiley   +2 more sources

Effect of 3-methyl-4-nitro-furoxan on morphology, thermal stability, rheological and mechanical properties of nitrocellulose (NC)-based energetic materials

FirePhysChem, 2021
The development of safe and facile strategy processing novel high-energy nitrocellulose (NC)-based propellants is urgently needed but challenging recently.
Lingfeng Yang, Xianrui Shi, Zhaoqian Li, Xiaohui Duan, Bo Wu, Chonghua Pei   +5 more
doaj   +1 more source

Polynitromethyl high-energy materials with a tricyclic furoxan-oxadiazole scaffold: Synthesis, stability, and detonation performance

Defence Technology
Polynitromethyl explosives exhibit outstanding detonation performance, yet their application is significantly hindered by safety concerns. Thus, enhancing the stability of polynitromethyl high-energy density materials (HEDMs) while maintaining high ...
Qi Xue, Lexing Xue, Panfeng Wu, Fuqiang Bi, Lianjie Zhai, Jiarong Zhang, Kaidi Yang, Junlin Zhang, Bozhou Wang   +8 more
doaj   +1 more source

Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events

Molecules, 2015
Thrombosis is the main outcome of many cardiovascular diseases. Current treatments to prevent thrombotic events involve the long-term use of antiplatelet drugs.
Leandro Augusto Rosseto, Maria Elisa Lopes Pires, Aylime Castanho Bolognesi Melchior, Priscila Longhin Bosquesi, Aline Renata Pavan, Sisi Marcondes, Man Chin Chung, Jean Leandro dos Santos   +7 more
doaj   +1 more source

Low sensitive energetic material based on the combination of furoxan and 1,3,4-oxadiazole structures

Energetic Materials Frontiers, 2020
In this study, a new series of 3-amino-4-(5-amino-1,3,4-oxadiazole-yl) furoxan derivatives including neutral compounds and energetic salts were synthesized.
Lei Qian, Hongwei Yang, Hualin Xiong, Hao Gu, Jie Tang, Yubing Xue, Guangbin Cheng   +6 more
doaj   +1 more source

Recent advances on the nitrogen-rich 1,2,4-oxadiazole-azoles-based energetic materials

Defence Technology, 2022
This review covers recent advances in the synthesis and energetic performance of nitrogen-rich 1,2,4-oxadiazole-azoles-based energetic materials. These materials comprise of 1,2,4-oxadiazole subunit as a key structural motif linked to different nitrogen ...
Wen-Li Cao, Qamar-un-Nisa Tariq, Zhi-Min Li, Jun-Qing Yang, Jian-Guo Zhang   +4 more
doaj   +1 more source

Synthesis of Alpha‐Acyloxy‐(1,2,5‐Oxadiazole‐2‐Oxide) Carboxamides via Passerini Multicomponent Reaction. Evaluation of Nitric Oxide‐Releasing and Anti‐Proliferative Properties

Journal of Heterocyclic Chemistry, Volume 62, Issue 10, Page 1285-1292, October 2025.
The Passerini multicomponent reaction was used to synthesize α‐acyloxy‐(1,2,5‐oxadiazole‐2‐oxide)carboxamides in good to excellent yields (67‐97%) under microwave heating. All compounds were able to release NO in solution, within the concentration range of 0.8–7.4 μM. Antiproliferative activity was investigated against LNCaP, MCF‐7, and SK‐MEL‐28 tumor
Nicolas S. Anjos, Gustavo S. Sant’Ana, João Vitor C. Santos, Caroline Alves, Ana Caroline S. Teodoro, Paulo Vinicius de Sousa, Hugo P. Monteiro, Luiz S. Longo Jr   +7 more
wiley   +1 more source

Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy

Advanced Science, Volume 12, Issue 31, August 21, 2025.
This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley   +1 more source

The CF3 Group as a Synthon of the CF+ Unit in Palladium Chemistry

Angewandte Chemie, Volume 136, Issue 26, June 21, 2024.
Pulling fluorine off: The unusually high activity of the C−F bond found in the homoleptic trifluoromethyl‐palladium(II) complex [Pd(CF3)4]2− is correlated to the very low fluoride‐ion affinity of the conjugate difluorocarbene complex [(CF3)3Pd(CF2)]−, which is experimentally detected.
Daniel Joven‐Sancho, Miguel Baya, Antonio Martín, Jesús Orduna, Babil Menjón   +4 more
wiley   +2 more sources