Mechanochemical Dimerization of Aldoximes to Furoxans [PDF]
Molecules, 2022 Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis.
Chuang Niu, Guan-Wu Wang
exaly +7 more sources
Proteomics Studies Suggest That Nitric Oxide Donor Furoxans Inhibit In Vitro Vascular Smooth Muscle Cell Proliferation by Nitric Oxide-Independent Mechanisms [PDF]
Molecules, 2023 Physiologically, smooth muscle cells (SMC) and nitric oxide (NO) produced by endothelial cells strictly cooperate to maintain vasal homeostasis. In atherosclerosis, where this equilibrium is altered, molecules providing exogenous NO and able to inhibit ...
Loretta Lazzarato +2 more
exaly +7 more sources
Regioselective Synthesis of NO-Donor (4-Nitro-1,2,3-triazolyl)furoxans via Eliminative Azide–Olefin Cycloaddition [PDF]
Molecules, 2023 A facile and efficient method for the regioselective [3 + 2] cycloaddition of 4-azidofuroxans to 1-dimethylamino-2-nitroethylene under p-TSA catalysis affording (4-nitro-1,2,3-triazolyl)furoxans was developed.
Irina A. Stebletsova +3 more
doaj +3 more sources
Bis-Oxadiazole Assemblies as NO-Releasing Anticancer Agents [PDF]
PharmaceuticsBackground: Malignant pleural mesothelioma (MPM) is an aggressive, asbestos-associated cancer characterized by dysregulated nitric oxide (NO) signaling and increased NO levels that facilitate tumor progression. Paradoxically, this aberrant NO environment
Egor M. Matnurov +7 more
doaj +3 more sources
Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors [PDF]
Molecules, 2021 Nitric oxide (NO) is a key signaling molecule that acts in various physiological processes such as cellular metabolism, vasodilation and transmission of nerve impulses.
Leonid L. Fershtat, Egor S. Zhilin
doaj +2 more sources
Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides [PDF]
Beilstein Journal of Organic Chemistry, 2022 Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides.
Md Imran Hossain +3 more
doaj +2 more sources
New Nitric Oxide-Releasing Compounds as Promising Anti-Bladder Cancer Drugs [PDF]
Biomedicines, 2023 Bladder cancer is a worldwide problem and improved therapies are urgently needed. In the search for newer strong antitumor compounds, herein, we present the study of three nitric oxide-releasing compounds and evaluate them as possible therapies for this ...
María Varela +8 more
doaj +2 more sources
Recent progress in synthesis and application of furoxan. [PDF]
RSC Adv, 2023 This review summarizes the recent advances in the synthesis and application of furoxan molecules, with special attention to the synthetic strategy of the post-ring introduction of substituents (PRIS).
Abu Yousef M, Matsubara R.
europepmc +3 more sources
Greener Synthesis of Antiproliferative Furoxans via Multicomponent Reactions [PDF]
Molecules, 2022 Prostate and bladder cancers are commonly diagnosed malignancies in men. Several nitric oxide donor compounds with strong antitumor activity have been reported.
Mariana Ingold +5 more
doaj +2 more sources
Synthetic Strategies Toward Nitrogen-Rich Energetic Compounds Via the Reaction Characteristics of Cyanofurazan/Furoxan [PDF]
Frontiers in Chemistry, 2022 The structural units of amino-/cyano-substituted furazans and furoxans played significant roles in the synthesis of nitrogen-rich energetic compounds. This account focused on the synthetic strategies toward nitrogen-rich energetic compounds through the ...
Luoluo Wang +5 more
doaj +2 more sources