Results 11 to 20 of about 451 (159)
Bioinspired Lipoproteins of Furoxans–Gemcitabine Preferentially Targets Glioblastoma and Overcomes Radiotherapy Resistance [PDF]
Advanced ScienceRadiotherapy (RT) resistance is an enormous challenge in glioblastoma multiforme (GBM) treatment, which is largely associated with DNA repair, poor distribution of reactive radicals in tumors, and limited delivery of radiosensitizers to the tumor sites ...
Maoyuan Sun +10 more
doaj +3 more sources
Synthesis of alkynyl furoxans. Rare carbon–carbon bond-forming reaction on a furoxan ring [PDF]
Organic & Biomolecular Chemistry, 2017 A novel C–C bond-forming reaction, alkynylation, on a furoxan ring is described.
Ryosuke Matsubara +3 more
core +4 more sources
Molbank, 2022 Functionally substituted 1,2,5-oxadiazole 2-oxides (furoxans) are important pharmaceutical scaffolds used for the preparation of various pharmacologically active substances.
Margarita A. Epishina +2 more
doaj +2 more sources
Exploring the Anticancer Potential of NO-Donor Oxadiazole Assemblies Against Malignant Pleural Mesothelioma [PDF]
PharmaceuticsBackground: Nitric oxide (NO) has been linked to the pathogenesis of asbestos-related pleural diseases, including an extremely aggressive cancer called malignant pleural mesothelioma (MPM). Given that MPM cells are characterized by a higher expression of
Irina A. Stebletsova +5 more
doaj +2 more sources
Synthesis and Synthetic Application of Chloro- and Bromofuroxans [PDF]
, 2020 Furoxans are potentially useful heteroaromatic units in pharmaceuticals and agrichemicals. However, the applications for furoxan-based compounds have been hampered due to the underdevelopment of their synthetic methods.
Hayu Hasebe +11 more
core +12 more sources
Synthesis and Characterisation of Diaryl Furoxans
Defence Science Journal, 2006 The paper discusses the synthesis, characterisation, and performance evaluation of diarylfuroxans namely, bis-phenyl-3,4-furoxan (5) and bis-(4’-nitrophenyl)-3,4-furoxan (6). Themolecules have been synthesised on the lines of reported method by cyclodimerisation of thenitrile oxides generated from benzaldoxime and p-nitro benzaldoxime, respectively ...
V. N. Krishnamurthy +4 more
openaire +3 more sources
, 2018 Nitric oxide (NO) mimetics and other agents capable of enhancing NO/cGMP signaling have demonstrated efficacy as potential therapies for Alzheimer’s disease.
Qasim Alhadidi (4026488) +15 more
core +5 more sources
Quantum chemical research of the molecular structure of 3,4-dicyanofuroxan
Тонкие химические технологии, 2023 Objectives. The study set out to determine the equilibrium parameters of the 3,4-dicyanofuroxan molecule by means of molecule geometry optimization by quantum chemistry methods, verify the adequacy of the methods used, and compare the obtained results ...
I. N. Kolesnikova +3 more
doaj +1 more source
Potassium (3-Methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide
Molbank, 2021 Furoxan derivatives enriched with explosophoric functionalities are promising compounds in the preparation of novel energetic materials. Herein, a previously unknown potassium (3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide (also referred to as ...
Egor S. Zhilin +2 more
doaj +1 more source
Peptide-Based Biomaterials as a Promising Tool for Cancer Radiotherapy. [PDF]
Adv Sci (Weinh)This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Wang Q, Chu X, Liu J.
europepmc +2 more sources