Results 41 to 50 of about 451 (159)
ChemMedChem, Volume 20, Issue 9, May 5, 2025.The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley +1 more source
Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents
, 2012 Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents adjacent to the furoxan ring system led to modulation of reactivity toward bioactivation, studied
Schiefer IT +4 more
core +1 more source
Benzofuroxans: A Possible +100 Years Old Misunderstanding?
ChemPhysChem, Volume 26, Issue 3, February 1, 2025.Since 1912 benzofuraxans have been believed to be constituted by a benzene ring fused with a pentatomic ring (a N−O−N bridge) and a N+→O− bond. A careful analysis of the electronic and topological properties of strategic representatives of this class of compounds, compared to the corresponding benzofurazans, revealed a different interpretation ...
Irina V. Galkina +6 more
wiley +1 more source
Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents
, 2016 Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents adjacent to the furoxan ring system led to modulation of reactivity toward bioactivation, studied
Lawren VandeVrede (446941) +4 more
core +1 more source
, 2018 Isosorbide was functionalized with furoxan for the first time to give adducts that release nitric oxide up to 7.5 times faster than the commercial vasodilator, isosorbide-5-mononitrate (Is5N).
Richard J. Singer (5146304) +7 more
core +1 more source
Food Science &Nutrition, Volume 13, Issue 1, January 2025.The paper highlights coumarin's ability to induce apoptosis, inhibit cell proliferation, and interfere with cancer cell signaling pathways. Coumarin disrupts key signaling pathways, including NF‐κB and PI3K/Akt, which are crucial for cancer cell survival and proliferation.
Muhammad Shahbaz +14 more
wiley +1 more source
Emerging nitric oxide gas‐assisted cancer photothermal treatment
Exploration, Volume 4, Issue 6, December 2024.A comprehensive review summarizes recent advancements in nitric oxide (NO) gas‐assisted cancer photothermal treatment. It commences by providing various types of NO donors/precursors for dual‐modal therapy. Subsequently, chemotherapy, photodynamic therapy, alkyl radical therapy, radiation therapy, immunotherapy, chemodynamic therapy, starvation therapy,
Shuang Liang +5 more
wiley +1 more source
Energetic Azoxy‐Coupled Tetrazoles
Journal of Heterocyclic Chemistry, Volume 61, Issue 11, Page 1704-1709, November 2024.5‐Amino‐2‐methyl‐tetrazole, above, left, when reacted with Oxone affords a transiently stable nitroso intermediate (blue solution). When the nitroso is reacted to completion, 5,5′‐azoxy‐bis‐2,2′‐methyl‐tetrazole is yielded as yellow rods. For scale reference, the microscope slide the crystals rest on is 22 mm × 22 mm. ABSTRACT Azoxy coupling of 5‐amino‐
Nicholas F. Scherschel +2 more
wiley +1 more source
Tuning Green Explosives through SNAr Chemistry
Chemistry – An Asian Journal, Volume 19, Issue 13, July 2, 2024.Graphical abstract showing a new concept for tuning the properties of environmentally benign primary explosives based on SNAr click‐chemistry. Abstract Reactivity and regioselectivity of SNAr‐type fluorine substitution with azide in polyfluorosubstituted nitrobenzenes was studied both theoretically and experimentally. The obtained polyazido‐substituted
Sergei Nikitin, Frederik Diness
wiley +1 more source
Atrans-Dinitrodiazenofuroxan Isomers-A DFT Treatise Lemi Türker
To Chemistry Journal, 2019 1,2,5-oxadiazole (furazanes) and their N-oxides are high-energy compounds. 4,4’-Dinitro-3,3’-diazenofuroxan is a powerful high-density high-explosives with performance comparable to that of other high-density high-explosives.
Lemi Türker
doaj +2 more sources