Results 21 to 30 of about 451 (159)

4,4′-Difluoro-[3,3′-bi(1,2,5-oxadiazole)] 2,2′-Dioxide

Molbank, 2023
1,2,5-Oxadiazole oxides (furoxans) are well known nitric oxide donors; among them, 4-fluorofuroxans have recently been found to be important photoinduced nitric oxide donors. In this research, it was shown that the reaction of 4,4′-dinitro-[3,3′-bi(1,2,5-
Natalia V. Obruchnikova, Oleg A. Rakitin
doaj   +1 more source

Enhanced Nitric Oxide Delivery Through Self-Assembling Nanoparticles for Eradicating Gram-Negative Bacteria. [PDF]

Adv Healthc Mater
This study presents an innovative approach to combat antibiotic‐resistant Gram‐negative bacteria by utilizing self‐assembling nanoparticles that deliver nitric oxide (NO). These nanoparticles, combined with polymyxin B, significantly enhance antibacterial efficacy at lower NO concentrations, disrupting bacterial membranes and reducing resistance ...
Lai X, Yu L, Huang X, Gardner W, Bamford SE, Pigram PJ, Wang S, Brun APL, Muir BW, Song J, Wang Y, Hsu HY, Chan PWH, Shen HH.   +13 more
europepmc   +2 more sources

Simple and energetic: Novel combination of furoxan and 1,2,4-triazole rings in the synthesis of energetic materials

Energetic Materials Frontiers, 2022
Two novel representatives of energetic (1,2,4-triazolyl)furoxans were prepared from the readily available (furoxanyl)amidrazones. Synthesized compounds were thoroughly characterized with IR and multinuclear NMR spectroscopy, elemental analysis and X-ray ...
Alexander A. Larin, Ivan V. Ananyev, Ekaterina V. Dubasova, Fedor E. Teslenko, Konstantin A. Monogarov, Dmitry V. Khakimov, Chun-lin He, Si-ping Pang, Galina A. Gazieva, Leonid L. Fershtat   +9 more
doaj   +1 more source

Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites. [PDF]

PLoS ONE, 2012
Parasitic flatworms are responsible for serious infectious diseases that affect humans as well as livestock animals in vast regions of the world. Yet, the drug armamentarium available for treatment of these infections is limited: praziquantel is the ...
Fabiana Ross, Paola Hernández, Williams Porcal, Gloria V López, Hugo Cerecetto, Mercedes González, Tatiana Basika, Carlos Carmona, Martín Fló, Gabriela Maggioli, Mariana Bonilla, Vadim N Gladyshev, Mariana Boiani, Gustavo Salinas   +13 more
doaj   +1 more source

Synthesis of Functionalized 4,5-Dihydroisoxazoles Decorated with the Dimethylphosphinoyl Group

Журнал органічної та фармацевтичної хімії, 2023
Aim. To synthesize a hybrid molecular platform incorporating dimethylphosphinoyl and 4,5-dihydroisoxazole moieties suitable for the creation of focused combinatorial libraries of compounds. Results and discussion.
Andrii V. Fedyk, Bohdan A. Chalyk
doaj   +1 more source

Synthesis of sulfonyloxy furoxans via hydroxyfuroxan ammonium salts [PDF]

, 2018
Furoxans are distinctive heteroaromatic compounds in that they are potentially capable of releasing nitric oxide under physiological conditions. In order to utilize the furoxan scaffold for the development of functional molecules, synthetically relevant ...
Katsuragi, Yuki, Shuhei Eguchi, Sakaguchi, Takaya, Eguchi, Shuhei, Ryosuke Matsubara, Ando, Akihiro, Yuki Katsuragi, Takaya Sakaguchi, Akihiro Ando, Hayashi, Masahiko, Matsubara, Ryosuke, Masahiko Hayashi   +11 more
core   +1 more source

Water Soluble Furoxan Derivatives as NO Prodrugs [PDF]

Journal of Medicinal Chemistry, 1997
The synthesis, characterization, NO donor properties, and in vitro vasodilating activity of a series of water soluble furoxans (5-14a,b) are described. All of the compounds released NO when treated with a large excess of cysteine under physiological conditions (pH 7.4; 37 degrees C).
SORBA GIOVANNI, MEDANA CLAUDIO, FRUTTERO ROBERTA, CENA CLARA, DI STILO ANTONALLA, GASCO ALBERTO, GALLI, Ubaldina   +6 more
openaire   +2 more sources

Modular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on “Build-and-Scrap” Strategy

, 2020
Utilizing radical chemistry, a new general C–C bond formation on the furoxan ring was developed. By taking advantage of the lability of furoxans, a wide variety of transformation of the synthesized furoxans have been demonstrated.
Yuto Nagoshi (8355909), Masahiko Hayashi (1320954), Masahiro Tateiwa (8355912), Hojin Kim (462672), Masahiro Yamanaka (1391734), Takaya Sakaguchi (8355903), Weibin Xie (306277), Takao Tsuneda (1925860), Ryosuke Matsubara (2142895), Akihiro Ando (8355915), Xufeng Zhao (8355906), Chaoyu Wang (14952)   +11 more
core   +1 more source

Nucleophilic dearomatization of 4-aza-6-nitrobenzofuroxan by CH acids in the synthesis of pharmacology-oriented compounds

Beilstein Journal of Organic Chemistry, 2017
4-Aza-6-nitrobenzofuroxan (ANBF) reacts with 1,3-dicarbonyl compounds and other CH acids to give carbon-bonded 1,4-adducts – 1,4-dihydropyridines fused with furoxan ring.
Alexey M. Starosotnikov, Dmitry V. Shkaev, Maxim A. Bastrakov, Ivan V. Fedyanin, Svyatoslav A. Shevelev, Igor L. Dalinger   +5 more
doaj   +1 more source

3,3′-(Diazene-1,2-diyl)bis[4-(nitroamino)-1,2,5-oxadiazole 2-oxide]

Molbank, 2018
The nitramino derivatives of furoxans are of specific interest as precursors for the preparation of high energy salts with nitrogen-rich cations. In this communication, the 3,3′-(diazene-1,2-diyl)bis[4-(nitroamino)-1,2,5-oxadiazole 2-oxide] was prepared ...
Alexander Larin, Igor Ovchinnikov, Leonid Fershtat, Nina Makhova   +3 more
doaj   +1 more source