Regioselective Synthesis of NO-Donor (4-Nitro-1,2,3-triazolyl)furoxans via Eliminative Azide–Olefin Cycloaddition [PDF]
Molecules, 2023 A facile and efficient method for the regioselective [3 + 2] cycloaddition of 4-azidofuroxans to 1-dimethylamino-2-nitroethylene under p-TSA catalysis affording (4-nitro-1,2,3-triazolyl)furoxans was developed.
Irina A. Stebletsova +3 more
doaj +2 more sources
Synthetic Strategies Toward Nitrogen-Rich Energetic Compounds Via the Reaction Characteristics of Cyanofurazan/Furoxan [PDF]
Frontiers in Chemistry, 2022 The structural units of amino-/cyano-substituted furazans and furoxans played significant roles in the synthesis of nitrogen-rich energetic compounds. This account focused on the synthetic strategies toward nitrogen-rich energetic compounds through the ...
Luoluo Wang +5 more
doaj +2 more sources
An Unusual Rearrangement of Pyrazole Nitrene and Coarctate Ring-Opening/Recyclization Cascade: Formal CH–Acetoxylation and Azide/Amine Conversion without External Oxidants and Reductants [PDF]
Molecules, 2023 We report an unusual transformation where the transient formation of a nitrene moiety initiates a sequence of steps leading to remote oxidative C–H functionalization (R–CH3 to R–CH2OC(O)R’) and the concomitant reduction of the nitrene into an amino group.
Elena Chugunova +12 more
doaj +2 more sources
Design and Synthesis of Novel Purine Analogues as Potential IL‐1β Inhibitors Targeting Vascular Inflammation [PDF]
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.Initial screening of the synthesized compounds revealed that compounds MK175 and MK169 inhibited LPS‐induced IL‐1β release in human aortic smooth muscle cells. ABSTRACT Proinflammatory cytokine interleukin (IL)‐1β is a key mediator of the inflammatory response in atherosclerosis.
Dimitra T. Pournara +6 more
wiley +2 more sources
Exploring the Anticancer Potential of NO-Donor Oxadiazole Assemblies Against Malignant Pleural Mesothelioma [PDF]
PharmaceuticsBackground: Nitric oxide (NO) has been linked to the pathogenesis of asbestos-related pleural diseases, including an extremely aggressive cancer called malignant pleural mesothelioma (MPM). Given that MPM cells are characterized by a higher expression of
Irina A. Stebletsova +5 more
doaj +2 more sources
Screening Novel Furoxan Derivatives as Potential Inhibitors Targeting Thioredoxin Glutathione Reductase of Fasciola gigantica [PDF]
PharmaceuticalsBackground: Fascioliasis, caused by Fasciola species, is a significant public health concern affecting over 250 million people globally and causing annual economic losses exceeding USD 6 billion.
Yanhui Han +12 more
doaj +2 more sources
Novel family of nitrogen-rich energetic (1,2,4-triazolyl) furoxan salts with balanced performance [PDF]
Frontiers in Chemistry, 2022 Nitrogen-rich energetic materials comprised of a combination of several heterocyclic subunits retain their leading position in the field of materials science.
Alexander A. Larin +6 more
doaj +2 more sources
Utilizing Estra-1,3,5,16-Tetraene Scaffold: Design and Synthesis of Nitric Oxide Donors as Chemotherapeutic Resistance Combating Agents in Liver Cancer [PDF]
Molecules, 2023 A new series of nitric oxide-releasing estra-1,3,5,16-tetraene analogs (NO-∆-16-CIEAs) was designed and synthesized as dual inhibitors for EGFR and MRP2 based on our previous findings on estra-1,3,5-triene analog NO-CIEA 17 against both HepG2 and HepG2-R
Mahrous A. Abou-Salim +5 more
doaj +2 more sources
Bis-Oxadiazole Assemblies as NO-Releasing Anticancer Agents [PDF]
PharmaceuticsBackground: Malignant pleural mesothelioma (MPM) is an aggressive, asbestos-associated cancer characterized by dysregulated nitric oxide (NO) signaling and increased NO levels that facilitate tumor progression. Paradoxically, this aberrant NO environment
Egor M. Matnurov +7 more
doaj +2 more sources
Enhanced Nitric Oxide Delivery Through Self‐Assembling Nanoparticles for Eradicating Gram‐Negative Bacteria [PDF]
Advanced Healthcare Materials, Volume 13, Issue 32, December 27, 2024.This study presents an innovative approach to combat antibiotic‐resistant Gram‐negative bacteria by utilizing self‐assembling nanoparticles that deliver nitric oxide (NO). These nanoparticles, combined with polymyxin B, significantly enhance antibacterial efficacy at lower NO concentrations, disrupting bacterial membranes and reducing resistance ...
Xiangfeng Lai +13 more
wiley +2 more sources