Results 21 to 30 of about 488 (118)

Synthesis of oxadiazole-2-oxide derivatives as potential drug candidates for schistosomiasis targeting SjTGR

Parasites & Vectors, 2021
Background Schistosomiasis is a chronic parasitic disease that affects millions of people’s health worldwide. Because of the increasing drug resistance to praziquantel (PZQ), which is the primary drug for schistosomiasis, developing new drugs to treat ...
Gongming Li, Qingqing Guo, Chao Feng, Huan Chen, Wenjiao Zhao, Shu Li, Yang Hong, Dequn Sun   +7 more
doaj   +1 more source

Initial unimolecular decomposition of 3,4-bis(3-fluorodinitromethylfuroxan-4-yl) furoxan from quantum mechanics and ReaxFF molecular dynamics simulation

FirePhysChem, 2023
High-energy-density materials (HEDMs) have a wide range of applications in many usages. Recently synthesized 3,4-bis(3-fluorodinitromethylfuroxan-4-yl) furoxan (BFTF-1), composed of furoxan rings and fluorodinitromethyl groups, has shown advanced ...
Jianxin Li, Panpan Heng, Baoshan Wang, Bozhou Wang, Ning Liu, Xiaocong Wang   +5 more
doaj   +1 more source

Nitro-, Cyano-, and Methylfuroxans, and Their Bis-Derivatives: From Green Primary to Melt-Cast Explosives

Molecules, 2020
In the present work, we studied in detail the thermochemistry, thermal stability, mechanical sensitivity, and detonation performance for 20 nitro-, cyano-, and methyl derivatives of 1,2,5-oxadiazole-2-oxide (furoxan), along with their bis-derivatives ...
Alexander A. Larin, Dmitry M. Bystrov, Leonid L. Fershtat, Alexey A. Konnov, Nina N. Makhova, Konstantin A. Monogarov, Dmitry B. Meerov, Igor N. Melnikov, Alla N. Pivkina, Vitaly G. Kiselev, Nikita V. Muravyev   +10 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of a Novel VEGFR-2 Inhibitor Based on a 1,2,5-Oxadiazole-2-Oxide Scaffold with MAPK Signaling Pathway Inhibition

Pharmaceuticals, 2022
Over the past few decades, the development of broad-spectrum anticancer agents with anti-angiogenic activity has witnessed considerable progress. In this study, a new series of pyrazolo[3,4-d]pyrimidines based on a phenylfuroxan scaffold were designed ...
Mater H. Mahnashi, Fardous F. El-Senduny, Mohammed Abdulrahman Alshahrani, Mahrous A. Abou-Salim   +3 more
doaj   +1 more source

Design, synthesis and biological evaluation of N-oxide derivatives with potent in vivo antileishmanial activity

PLoS ONE, 2021
Leishmaniasis is a neglected disease that affects 12 million people living mainly in developing countries. Herein, 24 new N-oxide-containing compounds were synthesized followed by in vitro and in vivo evaluation of their antileishmanial activity ...
Leandro da Costa Clementino, Guilherme Felipe Santos Fernandes, Igor Muccilo Prokopczyk, Wilquer Castro Laurindo, Danyelle Toyama, Bruno Pereira Motta, Amanda Martins Baviera, Flávio Henrique-Silva, Jean Leandro dos Santos, Marcia A. S. Graminha   +9 more
doaj   +2 more sources

Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues. [PDF]

PLoS ONE, 2018
Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature.
Emilian Georgescu, Anca Oancea, Florentina Georgescu, Alina Nicolescu, Elena Iulia Oprita, Lucian Vladulescu, Marius-Constantin Vladulescu, Florin Oancea, Sergiu Shova, Calin Deleanu   +9 more
doaj   +1 more source

3-Phenylsulfanyl-4-phenylsulfonyl-1,2,5-oxadiazole 2-oxide

Acta Crystallographica Section E, 2010
In the title compound, C14H10N2O4S2,the furoxan heterocyclic ring and the two S atoms are almost co-planar, with a mean deviation of 0.036 Å.
Giuliana Gervasio, Federica Bertolotti, Domenica Marabello   +2 more
doaj   +1 more source

Simple and energetic: Novel combination of furoxan and 1,2,4-triazole rings in the synthesis of energetic materials

Energetic Materials Frontiers, 2022
Two novel representatives of energetic (1,2,4-triazolyl)furoxans were prepared from the readily available (furoxanyl)amidrazones. Synthesized compounds were thoroughly characterized with IR and multinuclear NMR spectroscopy, elemental analysis and X-ray ...
Alexander A. Larin, Ivan V. Ananyev, Ekaterina V. Dubasova, Fedor E. Teslenko, Konstantin A. Monogarov, Dmitry V. Khakimov, Chun-lin He, Si-ping Pang, Galina A. Gazieva, Leonid L. Fershtat   +9 more
doaj   +1 more source

Potassium (3-Methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide

Molbank, 2021
Furoxan derivatives enriched with explosophoric functionalities are promising compounds in the preparation of novel energetic materials. Herein, a previously unknown potassium (3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide (also referred to as ...
Egor S. Zhilin, Dmitry B. Meerov, Leonid L. Fershtat   +2 more
doaj   +1 more source

Nucleophilic dearomatization of 4-aza-6-nitrobenzofuroxan by CH acids in the synthesis of pharmacology-oriented compounds

Beilstein Journal of Organic Chemistry, 2017
4-Aza-6-nitrobenzofuroxan (ANBF) reacts with 1,3-dicarbonyl compounds and other CH acids to give carbon-bonded 1,4-adducts – 1,4-dihydropyridines fused with furoxan ring.
Alexey M. Starosotnikov, Dmitry V. Shkaev, Maxim A. Bastrakov, Ivan V. Fedyanin, Svyatoslav A. Shevelev, Igor L. Dalinger   +5 more
doaj   +1 more source