Results 41 to 50 of about 488 (118)

New Synthetic Route to 4,6‐Diamino‐5,7‐dinitro‐benzo‐furazan, Important Decomposition Product of 1,3,5‐Triamino‐2,4,6‐trinitrobenzene

Propellants, Explosives, Pyrotechnics, Volume 50, Issue 7, Page 7-10, July 2025.
The well‐known insensitive high explosive, 1,3,5‐triamino‐2,4,6‐trinitrobenzene (TATB), decomposes in abnormal environments, such as heat and impact, to produce, in part, 4,6‐diamino‐5,7‐dinitro‐benzo‐furazan (F1). This reaction has been documented for almost 50 years, but the structure of F1 has remained elusive.
Mao‐Xi Zhang, Andrew T. Kerr, Alan J. DeHope, John G. Reynolds   +3 more
wiley   +1 more source

A Novel Energetic Nitroform Salt Derived from Bis-(Triazolyl)-Furoxan

Crystals
This study presents the synthesis and comprehensive characterization of a novel nitroform salt, bis(2-methyl-3-amino-1,2,4-triazolyl)furoxan trinitromethanide (compound 2), derived from the molecular scaffold of bis-(2-methyl-3-amino-1,2,4-triazolyl ...
Fawei Wang, Jiapeng Wang, Zihu Wang, Jianhua Wang, Yucun Liu   +4 more
doaj   +1 more source

Systematic Review on 1,2,3‐Oxadiazoles, 1,2,4‐Oxadiazoles, and 1,2,5‐Oxadiazoles in the Antimycobacterial Drug Discovery

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley   +1 more source

Benzofuroxans: A Possible +100 Years Old Misunderstanding?

ChemPhysChem, Volume 26, Issue 3, February 1, 2025.
Since 1912 benzofuraxans have been believed to be constituted by a benzene ring fused with a pentatomic ring (a N−O−N bridge) and a N+→O− bond. A careful analysis of the electronic and topological properties of strategic representatives of this class of compounds, compared to the corresponding benzofurazans, revealed a different interpretation ...
Irina V. Galkina, Dmitriy I. Bakhtiyarov, Semen R. Romanov, Luiza M. Usupova, Yulia V. Bakhtiyarova, Haiyan Fan, Enrico Benassi   +6 more
wiley   +1 more source

Synthesis of melt-castable gem-dinitro derivatives of 4,5,6,7-tetrahydrobenzofurazan and its N-oxide

FirePhysChem
The synthesis of energetic compounds of the gem-dinitrocarbocycle family, furazan and furoxan fused to dinitrocyclohexane, is reported. The construction of the gem-dinitro moiety was achieved by nitration of the hydroxyimine group by using both fuming ...
Albert G. Nigmatov, Kyrill Yu. Suponitsky, Valery P. Sinditskii, Aleksei B. Sheremetev   +3 more
doaj   +1 more source

Synthesis and Biological Evaluation of Novel Furozan-Based Nitric Oxide-Releasing Derivatives of Oridonin as Potential Anti-Tumor Agents

Molecules, 2012
To search for novel nitric oxide (NO) releasing anti-tumor agents, a series of novel furoxan/oridonin hybrids were designed and synthesized. Firstly, the nitrate/nitrite levels in the cell lysates were tested by a Griess assay and the results showed that
Hao Cai, Yihua Zhang, Jinyi Xu, Dahong Li, Lei Wang   +4 more
doaj   +1 more source

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

Journal of Inflammation, 2008
Background The cytoprotective nature of nitric oxide (NO) led to development of NO-aspirins in the hope of overcoming the gastric side-effects of aspirin.
Fox Sarah, Gasco Alberto, Fruttero Roberta, Cena Clara, Lazzarato Loretta, Sheldrake Tara A, Marcarino Paolo, Turnbull Catriona M, Megson Ian L, Rossi Adriano G   +9 more
doaj   +1 more source

Recent Perspectives on Anticancer Potential of Coumarin Against Different Human Malignancies: An Updated Review

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
The paper highlights coumarin's ability to induce apoptosis, inhibit cell proliferation, and interfere with cancer cell signaling pathways. Coumarin disrupts key signaling pathways, including NF‐κB and PI3K/Akt, which are crucial for cancer cell survival and proliferation.
Muhammad Shahbaz, Asfa Perween, Ushna Momal, Muhammad Imran, Muhammad Hammad Ul Hassan, Hammad Naeem, Ahmed Mujtaba, Muzzamal Hussain, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Ahmed H. El‐Ghorab, Samy Selim, Ehab M. Mostafa, Entessar Al Jbawi   +14 more
wiley   +1 more source

Emerging nitric oxide gas‐assisted cancer photothermal treatment

Exploration, Volume 4, Issue 6, December 2024.
A comprehensive review summarizes recent advancements in nitric oxide (NO) gas‐assisted cancer photothermal treatment. It commences by providing various types of NO donors/precursors for dual‐modal therapy. Subsequently, chemotherapy, photodynamic therapy, alkyl radical therapy, radiation therapy, immunotherapy, chemodynamic therapy, starvation therapy,
Shuang Liang, Yufei Liu, Hongquan Zhu, Guangfu Liao, Wenzhen Zhu, Li Zhang   +5 more
wiley   +1 more source

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of furoxan derivatives of chromone were prepared. The antiproliferative activities were tested against five cancer cell lines HepG2, MCF-7, HCT-116, B16, and K562, and two normal human cell lines L-02 and PBMCs.
Runwei Jiao, Fanxing Xu, Xiaofang Huang, Haonan Li, Weiwei Liu, Hao Cao, Linghe Zang, Zhanlin Li, Huiming Hua, Dahong Li   +9 more
doaj   +1 more source