Results 31 to 40 of about 281,828 (139)

Synthesis and antifungal activity of novel polyheterocyclic compounds containing fused 1,2,4-triazine moiety [PDF]

Arkivoc, 2008
Amino-4-(4-chlorophenyl)-7-hydrazino-8H-pyrazolo(4,3-e)(1,2,4)triazolo(1`,5`-a)pyridine- 5-carbonitrile (4) was synthesized from 4-(4-chlorophenyl)-1,6-diamino-2-oxo-1,2-dihydro- pyridine-3,5-dicarbonitrile (1). Reaction of 4 with α,β-bifunctional compounds gave pyrazolotriazinotriazolopyridines (8-14).
Magdy A. Ibrahim, Reda M. Abdel-Rahman, Ali M. Abdel-Halim, Salah S. Ibrahim, Hassan A. Allimony   +4 more
openaire   +1 more source

Privileged Substructure-Based Diversity-Oriented Synthesis Pathway for Diverse Pyrimidine-Embedded Polyheterocycles

, 2016
A new diversity-oriented synthesis pathway for the fabrication of a pyrimidine-embedded polyheterocycles library was developed for potential interactions with diverse biopolymers.
Seung Bum Park (197493), Heejun Kim (1883626), Truong Thanh Tung (1883623)   +2 more
core   +1 more source

Research on synthesis of microwave‐assisted heterocyclic compounds with eco‐friendly solvents and transition metals via C–H activation

Bulletin of the Korean Chemical Society, Volume 47, Issue 4, Page 384-395, April 2026.
This review summarizes microwave‐assisted transition‐metal catalysis for constructing N‐ and O‐heterocycles, highlighting rapid C–H and pre‐activated C–X activation, improved selectivity, and green synthetic efficiency. Abstract Microwave‐assisted organic synthesis provides a rapid and sustainable platform for synthesizing various heterocycles ...
Woo‐Jin Park, Ye Ri Han, Hyejeong Lee
wiley   +1 more source

One‐Pot Three‐Component Coupling Access to Indolizine‐Pyrrolodiazepine Hybrid Structures

Asian Journal of Organic Chemistry, Volume 14, Issue 6, June 2025.
One‐pot three‐component coupling of pyridine‐2‐acetonitrile, N‐substituted pyrrole‐2‐carboxaldehyde, and TMSCN in the presence of DBU allowed facile access to a novel indolizine‐pyrrolodiazepine hybrid structure via a domino aldol condensation‐Michael addition‐cycloisomerization‐imine formation process enabling sequential construction of two ...
Sunhee Lee, Seonghyeon Nam, Ikyon Kim
wiley   +1 more source

Palladium‐Catalyzed [3+2+2] Cycloaddition Between Carbonyl‐Tethered Alkylidenecyclopropanes and Isocyanates

Helvetica Chimica Acta, Volume 108, Issue 5, May 2025.
Abstract Carbonyl‐tethered alkylidenecyclopropanes can react with aryl isocyanates in presence of Pd(0)‐phosphoramidite catalysts to give seven‐membered heterobicyclic products in a formal [3+2+2] cycloaddition process. The reaction involves the formation of a palladium π‐allyl complex intermediate (A), which behaves as a formal 1,5‐dipole, and can be ...
Ricardo Rodiño, Jose L. Mascareñas, Fernando López   +2 more
wiley   +1 more source

Enantioselective Cascade Reactions of Aminocatalytic Dienamines and Trienamines Initiated by a Cycloaddition Reaction

Chemistry – A European Journal, Volume 31, Issue 1, January 2, 2025.
This review outlines and showcases how aminocatalytic dienamines and trienamines can be used in stereoselective cascade reactions, that are initiated by a cycloaddition reaction to rapidly access complex chiral molecules. We aspire that the chemical community can use this review to design new cascade reaction or use current methodologies in complex ...
Jonas Faghtmann, Signe Sofie Pladsbjerg Andresen, Anne Rask Østergaard, Karl Anker Jørgensen   +3 more
wiley   +1 more source

Pyridine-Fused 2‑Pyridones via Povarov and A³ Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding

, 2019
We here describe the use of three-component reactions to synthesize tricyclic pyridine ring-fused 2-pyridones. The developed protocols have a wide substrate scope and allow for the installation of diverse chemical functionalities on the tricyclic central
Pardeep Singh (294895), Anders Olofsson, Jörgen Ådén (1820980), Dan E. Adolfsson, Brännström, Kristoffer, Olofsson, Anders, Cairns, Andrew G.,, Christian Bartens (6483092), Adolfsson, Dan E., Olofsson, Anders,, Bartens, Christian, Kristoffer Brännström, Pardeep Singh, Adolfsson, Dan E.,, Jörgen Ådén, Fredrik Almqvist (698391), Kristoffer Brännström (1541734), Singh, Pardeep,, Andrew G. Cairns, Cairns, Andrew G., Ådén, Jörgen,, Ådén, Jörgen, Christian Bartens, Anders Olofsson (343002), Singh, Pardeep, Dan E. Adolfsson (6483089), Almqvist, Fredrik, Brännström, Kristoffer,, Andrew G. Cairns (1282671), Fredrik Almqvist, Almqvist, Fredrik,   +30 more
core   +1 more source

Metal‐Free Bicyclization for the Construction of N‐O Fused Tetracyclic Isoquinolones

Asian Journal of Organic Chemistry, 2023
A hypervalent iodine‐mediated bicyclization of N‐alkoxybenzamides for the synthesis of polyheterocycles is reported. Through metal‐free strategy, various N‐O fused tetracyclic isoquinolones are synthesized in moderate to good yields at room temperature ...
Zhenwei Lv, Yan Li, Lingchao Cai, Liangliang Song   +3 more
semanticscholar   +1 more source

Catalytic Enantioselective Functionalization of Maleimides: An Update

Chinese Journal of Chemistry, Volume 42, Issue 24, Page 3605-3622, 15 December 2024.
Maleimides are multisite‐reactive scaffolds that have stimulated a growing interest in the field of synthetic organic chemistry. The present review covers the utilization of maleimides as electrophilic partners and pro‐nucleophilic partners in metal‐catalyzed or organocatalyzed functionalizations with the control of either central and/or axial ...
Muriel Amatore, Damien Bonne, Thierry Constantieux, Jean Rodriguez   +3 more
wiley   +1 more source

1,2‐Diaza‐1,3‐Dienes as a Multifaceted Synthons for the Synthesis of Heterocycles: A Fifteen‐Years Update

European Journal of Organic Chemistry, Volume 27, Issue 44, November 25, 2024.
1,2‐Diaza‐1,3‐butadienes, also called azoalkenes, have received considerable attention as key synthons for constructing various heterocyclic scaffolds. This minireview summarizes the contribution of our group in this field over the period from 2009 to the present, focusing on the role of the azoene building block in forming the heterocyclic structures.
Lucia De Crescentini, Giacomo Mari, Stefania Santeusanio, Gianfranco Favi, Fabio Mantellini   +4 more
wiley   +1 more source