Results 21 to 30 of about 281,828 (139)

An Easy Access to Furan-Fused Polyheterocyclic Systems

Molecules, 2022
Nitrostilbenes characterized by two different or differently substituted aryl moieties can be obtained from the initial ring-opening of 3-nitrobenzo[b]thiophene with amines. Such versatile building blocks couple the well-recognized double electrophilic reactivity of the nitrovinyl moiety (addition to the double bond, followed by, e.g., intramolecular ...
Alice Benzi, Lara Bianchi, Gianluca Giorgi, Massimo Maccagno, Giovanni Petrillo, Domenico Spinelli, Cinzia Tavani   +6 more
openaire   +4 more sources

Geometrically Compelled Silicon(II)/Silicon(IV) Donor–Acceptor Interaction Enables the Enamination of Nitriles

Angewandte Chemie, Volume 135, Issue 49, December 4, 2023., 2023
Hydrido‐benzosiloles bearing a side arm of the silylenyl group are prepared, all featuring the unique silicon(II)→silicon(IV) donor‐acceptor interaction that facilitates the enamination of α‐H‐bearing nitriles to afford the edge‐fused Si‐heterotricycles.
Deliang Kong, Jiancheng Li, Wen Dai, Liuying Jiang, Yiling Zhao, Hongping Zhu, Gang Fu, Herbert W. Roesky   +7 more
wiley   +2 more sources

Recent Applications of Quinolinium Salts in the Synthesis of Annulated Heterocycles

SynOpen, 2022
Quinoline derivatives are frequently found in natural products and biologically active compounds; however, construction of quinoline fused polyheterocycles is a challenging goal in synthetic organic chemistry.
Suven Das
doaj   +1 more source

A Stereospecific Alkene 1,2‐Aminofunctionalization Platform for the Assembly of Complex Nitrogen‐Containing Ring Systems

Angewandte Chemie, Volume 135, Issue 16, April 11, 2023., 2023
TFA promoted deprotection of O−Ts activated N‐Boc hydroxylamines triggers aminofunctionalization‐based polycyclizations of tethered alkenes. The processes involve intramolecular stereospecific aza‐Prilezhaev alkene aziridination in advance of stereospecific C−N cleavage by a pendant nucleophile.
Yuxiang Zhu, Matthew J. S. Smith, Wenbin Tu, John F. Bower   +3 more
wiley   +2 more sources

Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions [PDF]

Organic Letters, 2020
In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered formation of up to eight new bonds (one C-O, two C-C, five C-N).
Francesco Pancrazzi, Nicolò Sarti, Paolo P. Mazzeo, Alessia Bacchi, Carla Carfagna, Raffaella Mancuso, Bartolo Gabriele, Mirco Costa, András Stirling, Nicola Della Ca’   +9 more
openaire   +5 more sources

Palladium‐Catalyzed Carbonylation of Multifunctionalized Substituted Alkynes to Quinolinone Derivatives under Mild Conditions†

Chinese Journal of Chemistry, Volume 41, Issue 23, Page 3223-3228, 1 December 2023., 2023
Fused oxazino‐quinolinone derivatives have been obtained in high yield and selectivity by mild palladium‐catalyzed carbonylation protocols (atmospheric pressure and mild reaction temperature). Gaseous CO can be replaced with surrogates such as TFBen or hexa‐formate calix[6]arenes (CLX[6]CO), which have been employed for the first time as solid ...
Aleksandr Voronov, Francesco Pancrazzi, Ana Maria Constantin, Raimondo Maggi, Raffaella Mancuso, Bartolo Gabriele, Diego Olivieri, Carla Carfagna, Alessandro Casnati, Francesco Rispoli, Laura Baldini, Nicola Della Ca   +11 more
wiley   +1 more source

On Route to Diverse Nitrogen‐Bridged Polyhetero‐cycles with an N(acyl), N(aryl)‐acetal Core

ChemistrySelect, Volume 8, Issue 20, May 25, 2023., 2023
We developed here the synthesis of new tetracyclic structures incorporating both aniline and isoindolinone nucleus, by exploiting the sequential nucleophilic and electrophilic reactivities of suitable o‐substituted aniline with 1‐formylbenzonitrile.
Valerio Morlacci, Tonino Caruso, Marco Chiarini, Vincenzo Marsicano, Antonio Arcadi, Laura Palombi   +5 more
wiley   +1 more source

Synthesis of Natural Product-like Polyheterocycles via One-Pot Cascade Oximation, C–H Activation, and Alkyne Annulation

, 2016
An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was developed.
Yunhui Bin (2067283), Yunpeng Wang (172933), Ruimao Hua (1545895), Liyao Zheng (1545889)   +3 more
core   +3 more sources

Synthesis and Transformations of NH‐Sulfoximines

Chemistry – A European Journal, Volume 27, Issue 69, Page 17293-17321, December 9, 2021., 2021
This review considered recent progress and achievements in the synthesis and transformation of NH‐sulfoximines. The development of strategies for direct and selective preparation of NH‐sulfoximines, even in enantioenriched form or by using sustainable approaches and continuous flow synthesis, are reported. Transformations of sulfoximines by N−S, N−P, N−
Michael Andresini, Arianna Tota, Leonardo Degennaro, James A. Bull, Renzo Luisi   +4 more
wiley   +1 more source

Electrophilic Aminating Agents in Total Synthesis

Angewandte Chemie, Volume 133, Issue 49, Page 25844-25870, December 1, 2021., 2021
This Review outlines the strategic use of electrophilic aminating agents in total synthesis. A wide range of C−N bond‐forming methods are highlighted, including polar, radical and transition‐metal‐catalyzed processes. Abstract Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in ...
Lauren G. O'Neil, John F. Bower
wiley   +1 more source