Results 131 to 140 of about 1,959,868 (292)

Potent inhibition of arenavirus infection by a novel fusion inhibitor. [PDF]

Antiviral Res, 2021
Gowen BB, Naik S, Westover JB, Brown ER, Gantla VR, Fetsko A, Dagley AL, Blotter DJ, Anderson N, McCormack K, Henkel G.   +10 more
europepmc   +1 more source

The Emerging Role of Fusion Inhibitors in HIV Infection

Drugs in R & D, 1999
Fusion of HIV with its host cell requires the interaction of the viral envelope glycoprotein 120 (gp120) with the chemokine receptor CXCR4 [T cell-tropic (T-tropic) or X4 HIV strains] or CCR5 [macrophage-tropic (M-tropic) or R5 HIV strains] followed by a 'spring-loaded' action of the glycoprotein 41 (gp41) that ensures fusion of the viral and cellular ...
openaire   +2 more sources

Supplemental Figure 3 from CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma

, 2015
Supplemental Figure 3. Further evaluation of CDK4/6 inhibitor sensitivity in fusion-positive and fusion-negative RMS cells.
Zied Abdullaev (8934557), Frederic G. Barr (14894705), Stephen M. Hewitt (190750), Mary E. Olanich (14998238), Wenyue Sun (134001), Svetlana D. Pack (8934554)   +5 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Severe mammarenaviral disease in guinea pigs effectively treated by an orally bioavailable fusion inhibitor, alone or in combination with favipiravir. [PDF]

Antiviral Res, 2022
Westover JB, Naik S, Bailey KW, Wandersee L, Gantla VR, Hickerson BT, McCormack K, Henkel G, Gowen BB.   +8 more
europepmc   +1 more source

After EBOV GP is cleaved, GP-mediated fusion is independent of pH.

, 2016
(A) Blocking delivery of EBOV GP to the cell surface yields pH-independent fusion: BFA was added to effector cells 45 min prior to mixing them with target cells, and then maintained to prevent EBOV GP trafficking to the plasma membrane.
Fredric S. Cohen (277044), Ruben M. Markosyan (277036), Yi-Min Zheng (277037), Gregory B. Melikyan (137795), Shan-Lu Liu (4773), Chunhui Miao (843005)   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

An HR2-Mimicking Sulfonyl-γ-AApeptide Is a Potent Pan-coronavirus Fusion Inhibitor with Strong Blood-Brain Barrier Permeability, Long Half-Life, and Promising Oral Bioavailability. [PDF]

ACS Cent Sci, 2023
Xue S, Xu W, Wang L, Wang X, Duan Q, Calcul L, Wang S, Liu W, Sun X, Lu L, Jiang S, Cai J.   +11 more
europepmc   +1 more source

A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3

, 2018
Increasing evidences reveal that autophagy inhibitor could enhance the effect of chemotherapy to cancer. However, few autophagy inhibitors are currently approved for clinical application in humans.
Qin Deng, Hongwei Zhang, Xiuxing Jiang, Ruoqiu Fu, Jinjiao Hu, Qingsong Luo, Yunong Li, Lirong Li, Ning Gao, Yanxia Liu, Yanhao Zhang, Chong Yang, Xiaoye Hu   +12 more
core   +1 more source