Results 121 to 130 of about 1,959,868 (292)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Fusion product studies via fast ion D–D and D–3He fusion on JET

, 2016
Dedicated fast ion D-D and D-3He fusion experiments were performed on JET with carbon wall (2008) and ITER-like wall (2014) for testing the upgraded neutron and energetic ion diagnostics of fusion products.
Mantsinen, M, Nabais, F, Schneider, M., Tsalas, M., Santala, M., Girardo, J-B, Hellsten, T, Eriksson, J., Kiptily, VG, Kazakov, Y, Zoita, V, Craciunescu, T., Johnson, Thomas,, Kiptily, V. G., Hellsten, Torbjörn,, Johnson, T, Nocente, M., Yavorskij, V., Eriksson, J, Johnson, T., Hjalmarsson, Anders,, Tsalas, M, Fitzgerald, M, Schneider, M, Hellesen, C., Rimini, F., Girardo, J.-B., Hellesen, Carl,, Santala, M, Hjalmarsson, A., Hjalmarsson, A, Kazakov, Y., Yavorskij, V, Monakhov, I., von Thun, C. Perez, Sharapov, S. E., Koskela, T., Nabais, F., Goloborod'Ko, V., Zoita, V., Sharapov, SE, Perez von Thun, C., Tardocchi, M., Monakhov, I, Rimini, F, Contributors, Jet, Goloborod’ko, V, Nocente, M, Hellesen, C, Craciunescu, T, Koskela, T, Fitzgerald, M., Tardocchi, M, von Thun, C Perez, Hellsten, T., Hjalmarson, Åke, Girardo, J. -B, Mantsinen, M., Eriksson, Jacob,   +58 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Multi Sensor Image Fusion using Empirical Mode Decomposition [PDF]

, 2013
Image fusion is a process of combining relevant information from two or more images from different sensors based on certain algorithm. Many algorithms have been proposed for pixel level image fusion.
Naidu, VPS, Shakthipriya, VS
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

A dePEGylated Lipopeptide-Based Pan-Coronavirus Fusion Inhibitor Exhibits Potent and Broad-Spectrum Anti-HIV-1 Activity without Eliciting Anti-PEG Antibodies. [PDF]

Int J Mol Sci, 2023
Xu L, Wang C, Xu W, Xing L, Zhou J, Pu J, Fu M, Lu L, Jiang S, Wang Q.   +9 more
europepmc   +1 more source

Computational Mechanism Design for Information Fusion within Sensor Networks

, 2006
Conventional centralised information fusion and control architectures will be challenged by developments in sensor networks that allow sophisticated autonomous sensors, owned by different stakeholders with individual goals, to interact and share ...
S. Reece, N. Jennings, Dash, Rajdeep K, Rogers, Alex, S. Roberts, Roberts, Stephen, Jennings, N. R., Reece, Steve, R. Dash, A. Rogers, Dash, Rajdeep K., Jennings, NR   +11 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of Spike

Viruses
Since the beginning of the COVID-19 pandemic, extensive drug repurposing efforts have sought to identify small-molecule antivirals with various mechanisms of action.
Matthew R. Freidel, Roger S. Armen
doaj   +1 more source