CryoET structures of immature HIV Gag reveal six-helix bundle [PDF]
Communications Biology, 2021 Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging.
Luiza Mendonça +13 more
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A combination vaccine against SARS-CoV-2 and H1N1 influenza based on receptor binding domain trimerized by six-helix bundle fusion core [PDF]
EBioMedicine, 2022 Summary: Background: Increasing severe morbidity and mortality by simultaneous or sequential infections with SARS-CoV-2 and influenza A viruses (IAV), especially in the elderly and obese patients, highlight the urgency of developing a combination ...
Rui Shi +10 more
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An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane [PDF]
Viruses, 2023 Human immunodeficiency virus type 1 (HIV-1) is characterized by high variability and drug resistance. This has necessitated the development of antivirals with a new chemotype and therapy.
Chao Wang +9 more
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Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection [PDF]
Retrovirology, 2018 Background The native pre-fusion structure of gp120/gp41 complex of human immunodeficiency virus type 1 was recently revealed. In the model, the helices of gp41 (α6, α7, α8, and α9) form a four-helix collar underneath trimeric gp120.
Dehua Liu +8 more
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Alpaca-derived nanobody targeting the hydrophobic pocket of the HIV-1 gp41 NHR broadly neutralizes HIV-1 by blocking six-helix bundle formation [PDF]
Current Research in Microbial SciencesThe highly conserved hydrophobic pocket region of HIV-1 gp41 NHR triple-stranded coiled coil is crucial for the binding of CHR to NHR to form a six-helix bundle (6-HB).
Lujia Sun +9 more
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Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheimer’s disease via cGAS-STING inhibition [PDF]
Journal of NanobiotechnologyAlzheimer’s disease (AD) pathological progression is intimately linked to microglial inflammatory activation mediated by the cGAS-STING pathway. Small interfering RNA targeting STING (siSTING) is a precise therapeutic to silence STING and interfere with ...
Manqing Zhang +15 more
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Salvianolic Acid C Potently Inhibits SARS-CoV-2 Infection by Blocking the Formation of Six-Helix Bundle Core of Spike Protein [PDF]
Signal Transduction and Targeted Therapy, 2020 Shuwen Liu, Jiang Shibo, Gengfu Xiao
exaly +2 more sources
Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations. [PDF]
PLoS ONE, 2014 We previously reported a series of antibodies, in fragment antigen binding domain (Fab) formats, selected from a human non-immune phage library, directed against the internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41.
John M Louis +6 more
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Rational Design of A Novel Small-Molecule HIV-1 Inactivator Targeting Both gp120 and gp41 of HIV-1
Frontiers in Pharmacology, 2021 Virus inactivator can inactivate cell-free virions without relying on their replication cycle, potentially reducing the impact of viral infection on cells. Previously, we successfully constructed a HIV-1 protein inactivator, 2DLT, by conjugating the D1D2
Jing Pu +13 more
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Viruses, 2022 The prolonged duration of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has resulted in the continuous emergence of variants of concern (VOC, e.g., Omicron) and variants of interest (VOI, e.g., Lambda).
Lixiao Xing +12 more
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