Results 31 to 40 of about 3,038,180 (280)
eLife, 2016 Many cancers overexpress one or more of the six human pro-survival BCL2 family proteins to evade apoptosis. To determine which BCL2 protein or proteins block apoptosis in different cancers, we computationally designed three-helix bundle protein ...
Stephanie Berger +18 more
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Biophysical property and broad anti-HIV activity of albuvirtide, a 3-maleimimidopropionic acid-modified peptide fusion inhibitor. [PDF]
PLoS ONE, 2012 Albuvirtide (ABT) is a 3-maleimimidopropionic acid (MPA)-modified peptide HIV fusion inhibitor that can irreversibly conjugate to serum albumin. Previous studies demonstrated its in vivo long half-life and potent anti-HIV activity.
Huihui Chong +6 more
doaj +1 more source
Mechanism of Na+-dependent citrate transport from the structure of an asymmetrical CitS dimer
eLife, 2015 The common human pathogen Salmonella enterica takes up citrate as a nutrient via the sodium symporter SeCitS. Uniquely, our 2.5 Å x-ray structure of the SeCitS dimer shows three different conformations of the active protomer.
David Wöhlert +3 more
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Six-helix bundle structure in the gp41 immunogens.
, 2015 Indirect ELISA of the indicated gp41 immunogens using a monoclonal antibody specific for the six-helix bundle (NC-1)[76]. Positive control is a recombinant six-helix bundle (N34C28).
Indresh K. Srivastava (120023) +12 more
core +1 more source
Frontiers in Pharmacology, 2019 The combination of three or more antiviral agents that act on different targets is known as highly active antiretroviral therapy (HAART), which is widely used to control HIV infection. However, because drug resistance and adverse effects occur after long-
Jiayin Qiu +12 more
doaj +1 more source
Viruses, 2022 In recent years, infectious diseases caused by viral infections have seriously endangered human health, especially COVID-19, caused by SARS-CoV-2, which continues to spread worldwide.
Jing Pu +8 more
doaj +1 more source
Six-Helix Bundle and Triangle DNA Origami Insulator-Based Dielectrophoresis
, 2016 Self-assembled DNA nanostructures have large potential for nanoelectronic circuitry, targeted drug delivery, and intelligent sensing. Their applications require suitable methods for manipulation and nanoscale assembly as well as adequate concentration ...
Tzu-Chiao Chao (1876081) +3 more
core +4 more sources
Viruses, 2019 The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available.
Shuai Xia +9 more
doaj +1 more source
Six-Helix and Eight-Helix DNA Nanotubes Assembled From Half-Tubes
, 2007 DMA nanotubes are cylinder-like structures formed from DNA double-helical molecules whose helix axes are fused at least twice by crossovers. It is potentially useful to use such tubes as sheaths around rodlike species that arise in biological systems and
Kuzuya, Akinori +3 more
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Three-helix-bundle protein in a Ramachandran model
, 2000 We study the thermodynamic behavior of a model protein with 54 amino acids that forms a three-helix bundle in its native state. The model contains three types of amino acids and five to six atoms per amino acid and has the Ramachandran torsional angles ...
Irbäck, A, +3 more
core +1 more source