Results 21 to 30 of about 3,038,180 (280)
Molecules, 2017 Peptides derived from the C-terminal heptad repeat (CHR) of human immunodeficiency virus type 1 (HIV-1) envelope protein transmembrane subunit gp41, such as T20 (enfuvirtide), can bind to the N-terminal heptad repeat (NHR) of gp41 and block six-helix ...
Shan Su +5 more
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Anti-HIV-1 activity of anionic polymers: a comparative study of candidate microbicides
BMC Infectious Diseases, 2002 Background Cellulose acetate phthalate (CAP) in soluble form blocks coreceptor binding sites on the virus envelope glycoprotein gp120 and elicits gp41 six-helix bundle formation, processes involved in virus inactivation.
Li Yun-Yao, Strick Nathan, Neurath A
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The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix
Frontiers in Molecular Biosciences, 2020 Voltage-gated potassium channels (Kv) allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bundle S1-S4 ...
Olivier Bignucolo +3 more
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A Study of Low pH-Induced Refolding of Env of Avian Sarcoma and Leukosis Virus into a Six-Helix Bundle [PDF]
Biophysical Journal, 2004 The fusion protein of avian sarcoma and leukosis virus is likely to fold into a six-helix bundle as part of its final configuration. A peptide, R99, inhibits fusion, probably by binding into the grooves of the triple-stranded coiled coil that becomes the central core of the six-helix bundle.
Markosyan, R.M. +3 more
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Frontiers in Cellular and Infection Microbiology, 2018 The deep hydrophobic pocket of HIV-1 gp41 has been considered a drug target, but short-peptides targeting this site usually lack potent antiviral activity.
Xiujuan Zhang +9 more
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Phylogenetic analysis of Harmonin homology domains
BMC Bioinformatics, 2021 Background Harmonin Homogy Domains (HHD) are recently identified orphan domains of about 70 residues folded in a compact five alpha-helix bundle that proved to be versatile in terms of function, allowing for direct binding to a partner as well as ...
Baptiste Colcombet-Cazenave +6 more
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Molecules, 2019 Enfuvirtide (T20) is the first U.S. FDA-approved HIV fusion inhibitor-based anti-HIV drug. Its clinical application is limited because of its low potency and short half-life.
Shan Su +7 more
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Cell Surface Assembly of HIV gp41 Six-Helix Bundles for Facile, Quantitative Measurements of Hetero-oligomeric Interactions [PDF]
Journal of the American Chemical Society, 2012 Helix-helix interactions are fundamental to many biological signals and systems and are found in homo- or heteromultimerization of signaling molecules as well as in the process of virus entry into the host. In HIV, virus-host membrane fusion during infection is mediated by the formation of six-helix bundles (6HBs) from homotrimers of gp41, from which a
Xuebo, Hu +6 more
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HIV-1 Envelope Proteins Complete Their Folding into Six-helix Bundles Immediately after Fusion Pore Formation [PDF]
Molecular Biology of the Cell, 2003 Fusion proteins of many viruses, including HIV-1 envelope protein (Env), fold into six-helix bundle structures. Fusion between individual Env-expressing cells and target cells was studied by fluorescence microscopy, and a temperature jump technique, to determine whether folding of Env into a bundle is complete by the time fusion pores have formed ...
Ruben M, Markosyan +2 more
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Retrovirology, 2012 Background Most currently approved anti-HIV drugs (e.g., reverse transcriptase inhibitors, protease inhibitors and fusion/entry inhibitors) must act inside or on surface of the target cell to inhibit HIV infection, but none can directly inactivate ...
Lu Lu +5 more
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