Results 101 to 110 of about 1,959,868 (292)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Synergistic inhibition of cell-to-cell HIV-1 infection by combinations of single chain variable fragments and fusion inhibitors

Biochemistry and Biophysics Reports, 2019
Cell-to-cell spread of HIV permits ongoing viral replication in the presence of antiretroviral therapy and is suggested to be a major contributor to sexual transmission by mucosal routes.
Mohammad Mamun Alam, Takeo Kuwata, Kazuki Tanaka, Muntasir Alam, Shokichi Takahama, Kazuya Shimura, Masao Matsuoka, Natsuki Fukuda, Hiroshi Morioka, Hirokazu Tamamura, Shuzo Matsushita   +10 more
doaj   +1 more source

Modular Assembly of Dimeric HIV Fusion Inhibitor Peptides with Enhanced Antiviral Potency [PDF]

, 2013
The HIV-1 envelope gp120/gp41 glycoprotein complex plays a critical role in virus-host cell membrane fusion and has been a focus for the development of HIV fusion inhibitors.
Tolbert, Thomas J., Xiao, Junpeng
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration

Frontiers in Molecular Neuroscience, 2019
Mitochondrial dysfunction is a recognized hallmark of neurodegenerative diseases and abnormal mitochondrial fusion-fission dynamics have been implicated in the pathogenesis of neurodegenerative disorders. This study characterizes the effects of metabolic
Darren O’Hara, Gavin M. Davis, Natalie A. Adlesic, Jerrard M. Hayes, Gavin P. Davey   +4 more
doaj   +1 more source

Supplementary Data from EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer

, 2008
Supplementary Data from EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung ...
Jhingook Kim (225926), Carly Murphy (14973631), Eugene Lifshits (14884349), Jeffrey A. Engelman (14884340), Derek Chiang (3582431), J. Paul Marcoux (14904005), Roman Thomas (8460015), Nathanael S. Gray (150685), William G. Richards (14871909), Jussi P. Koivunen (6540566), Jinseon Lee (279957), Pasi A. Jänne (1277622), Hwan Geun Choi (750017), Charles Lee (14206), Kreshnik Zejnullahu (14884343), Matthew Meyerson (24538), Christopher Ducko (14973637), Craig Mermel (218410), Alison J. Holmes (14973634), David J. Sugarbaker (14891088), Neal Lindeman (3564308)   +20 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors

Cell Reports Medicine
Summary: Unlike preceding MERS-related coronaviruses, the recently identified MjHKU4r-CoV-1 strain can directly infect human cells. Nonetheless, its potential pathogenic attributes and underlying molecular mechanisms remain unclear.
Shuai Xia, Fanke Jiao, Jing Chen, Lijue Wang, Tianyu Lu, Qian Wang, Wei Xu, Xinling Wang, Fei Sun, Yun Zhu, Peng Zhou, Shibo Jiang, Lu Lu   +12 more
doaj   +1 more source

Fragments of target cells are internalized into retroviral envelope protein-expressing cells during cell-cell fusion by endocytosis

Frontiers in Microbiology, 2016
Retroviruses enter into host cells by fusion between viral and host cell membranes. Retroviral envelope glycoprotein (Env) induces the membrane fusion, and also mediates cell-cell fusion.
Mai eIzumida, Haruka eKamiyama, Takashi eSuematsu, Eri eHonda, Yosuke eKoizumi, Kiyoshi eYasui, Hideki eHayashi, Koya eAriyoshi, Yoshinao eKubo   +8 more
doaj   +1 more source

TRK inhibitors in TRK fusion-positive cancers [PDF]

Annals of Oncology, 2019
TRK fusions are oncogenic drivers of various adult and paediatric cancers. The first-generation TRK inhibitors, larotrectinib and entrectinib, were granted landmark, tumour-agnostic regulatory approvals for the treatment of these cancers in 2018 and 2019, respectively.
openaire   +3 more sources