Results 11 to 20 of about 1,959,868 (292)

HIV-1 Entry and Membrane Fusion Inhibitors [PDF]

Viruses, 2021
HIV-1 (human immunodeficiency virus type 1) infection begins with the attachment of the virion to a host cell by its envelope glycoprotein (Env), which subsequently induces fusion of viral and cell membranes to allow viral entry.
Tianshu Xiao, Yongfei Cai, Bing Chen
doaj   +3 more sources

Supplementary Data from MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer

, 2022
Supplementary Data from MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung ...
Evan Siau (15031442), Adam J. Schoenfeld (15022025), Inna Khodos (14925354), Marissa S. Mattar (15028239), Igor Odintsov (14956143), Elisa de Stanchina (14954757), Monika A. Davare (14918172), Alexander Drilon (15014949), Marc Ladanyi (4470), Sudarshan R. Iyer (15010595), Romel Somwar (71236), Gregory J. Riely (4330525)   +11 more
core   +4 more sources

Development of a secreted cell-permeable NF-κB inhibitor to control inflammation [PDF]

, 2010
PhDRheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease, of unknown aetiology. Several disease-modulating approaches have been developed in the past years, however these are expensive, usually accompanied by unwanted side-effects ...
Koutsokeras, Apostolos
core   +4 more sources

Complementary approaches to target human respiratory syncytial virus using small molecule ligands [PDF]

, 2012
In the current project, situated at the interface of chemistry and virology, complementary drug discovery approaches (high-throughput screening and structurebased drug design) have been exploited in order to discover novel small molecule inhibitors of ...
Lardeau, Charles-Hugues Claude Jean
core   +5 more sources

Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus

Emerging Microbes and Infections, 2021
EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral ...
Danwei Yu, Yuanmei Zhu, Hongxia Yan, Tong Wu, Huihui Chong, Yuxian He   +5 more
doaj   +1 more source

SARS-CoV-2 Omicron subvariants exhibit distinct fusogenicity, but similar sensitivity, to pan-CoV fusion inhibitors

Emerging Microbes and Infections, 2023
Continuous emergence of the Omicron variant, along with its subvariants, has caused an increasing number of infections, reinfections, and vaccine-breakthrough infections, seriously threatening human health. Recently, several new Omicron subvariants, such
Shuai Xia, Lijue Wang, Fanke Jiao, Xueying Yu, Wei Xu, Ziqi Huang, Xicheng Li, Qian Wang, Yun Zhu, Qiuhong Man, Shibo Jiang, Lu Lu   +11 more
doaj   +1 more source

Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus

Viruses, 2017
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual outbreaks of MERS-CoV highlight the importance of developing antiviral therapeutics.
Yaping Sun, Huaidong Zhang, Jian Shi, Zhe Zhang, Rui Gong   +4 more
doaj   +1 more source

Supplementary Figure from MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer

, 2022
Supplementary Figure from MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung ...
Evan Siau (15031442), Adam J. Schoenfeld (15022025), Inna Khodos (14925354), Marissa S. Mattar (15028239), Igor Odintsov (14956143), Elisa de Stanchina (14954757), Monika A. Davare (14918172), Alexander Drilon (15014949), Marc Ladanyi (4470), Sudarshan R. Iyer (15010595), Romel Somwar (71236), Gregory J. Riely (4330525)   +11 more
core   +1 more source

Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors

mBio, 2022
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a serious threat to global public health, underscoring the urgency of developing effective therapies.
Seung Bum Park, Parker Irvin, Zongyi Hu, Mohsin Khan, Xin Hu, Qiru Zeng, Catherine Chen, Miao Xu, Madeleine Leek, Ruochen Zang, James Brett Case, Wei Zheng, Siyuan Ding, T. Jake Liang   +13 more
doaj   +1 more source

Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4

Viruses, 2019
The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available.
Shuai Xia, Qiaoshuai Lan, Jing Pu, Cong Wang, Zezhong Liu, Wei Xu, Qian Wang, Huan Liu, Shibo Jiang, Lu Lu   +9 more
doaj   +1 more source