Results 41 to 50 of about 341,243 (253)
Journal of VirologyPRO 140, a humanized anti-HIV monoclonal antibody targeting the cell coreceptor CCR5, is currently under clinical trials, but it only affects CCR5-tropic viruses. In this study, we have engineered two tandem fusion proteins (2P23-PRO140SC and 2P23-PRO140-
Hongxia Yan +8 more
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The Curious Case of Arenavirus Entry, and Its Inhibition
Viruses, 2012 Arenaviruses comprise a diverse family of enveloped negative-strand RNA viruses that are endemic to specific rodent hosts worldwide. Several arenaviruses cause severe hemorrhagic fevers in humans, including Junín and Machupo viruses in South America and ...
Joanne York, Jack H. Nunberg
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Characterization of Potent Fusion Inhibitors of Influenza Virus
PLOS ONE, 2015 ISSN:1932 ...
Rowse, Michael +8 more
openaire +7 more sources
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Viruses, 2019 Entry of HIV-1 into target cells is mediated by its envelope (Env) glycoprotein composed of the receptor binding subunit gp120 and the fusion protein gp41. Refolding of the gp41 N- and C-terminal heptad repeats (NHR and CHR) into a six-helix bundle (6-HB)
Xiuzhu Geng +7 more
doaj +1 more source
A fusion inhibitor on endosomes
The Journal of Cell Biology, 2003 ![Graphic][1] The fusion (right) of early endosomes (left) is inhibited by Hrs. Endocytosed proteins come together in the early endosome to be sorted to different locations. Some endosome fusion is needed to promote this mixing, but the process must be regulated both to stop ...
openaire +2 more sources
Geranylgeranylated Snares Are Dominant Inhibitors of Membrane Fusion [PDF]
The Journal of Cell Biology, 2000 Exocytosis in yeast requires the assembly of the secretory vesicle soluble N-ethylmaleimide–sensitive factor attachment protein receptor (v-SNARE) Sncp and the plasma membrane t-SNAREs Ssop and Sec9p into a SNARE complex. High-level expression of mutant Snc1 or Sso2 proteins that have a COOH-terminal geranylgeranylation signal instead of a ...
Eric Grote +3 more
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The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature
Pediatric Blood &Cancer, EarlyView.ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi +7 more
wiley +1 more source
Clinical perspective of fusion inhibitors for treatment of HIV [PDF]
Journal of Antimicrobial Chemotherapy, 2004 The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options for this specific group of patients are limited. The fusion inhibitor enfuvirtide represents the first new therapeutic option from a new drug class for this patient ...
J K, Rockstroh, S, Mauss
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source