Results 41 to 50 of about 1,959,868 (292)

Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket

Frontiers in Cellular and Infection Microbiology, 2018
The deep hydrophobic pocket of HIV-1 gp41 has been considered a drug target, but short-peptides targeting this site usually lack potent antiviral activity.
Xiujuan Zhang, Xiujuan Zhang, Yuanmei Zhu, Hao Hu, Senyan Zhang, Pengfei Wang, Huihui Chong, Jinsheng He, Xinquan Wang, Yuxian He   +9 more
doaj   +1 more source

Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection [PDF]

, 2010
Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons of the efficacy of these inhibitors have been carried out.
Stephen E. Braun, Berger Annemarie, John J Rossi, Stephen E Braun, Kimpel, Janine, Conolle Michelle, Annemarie Berger, R Paul Johnson, Schmitz, Jörn E., Qiu Gang, Schmitz Jörn E., Qiu, Gang, John J. Rossi, Dorothee von Laer, Wong Fay Eng, Laer, Dorothee von, Boro Dropulic, Humeau, Laurent M., Humeau Laurent M., Christian Brendel, Conolle, Michelle, Brendel Christian, Michelle Conolle, Laurent M Humeau, Braun, Stephen E., Brendel, Christian, Jörn E Schmitz, Wong, Fay Eng, Janine Kimpel, Gang Qiu, Dropulic Boro, von Laer Dorothee, Berger, Annemarie, Jörn E. Schmitz, R. Paul Johnson, Rossi, John J., Rossi John J., Laurent M. Humeau, Fay Eng Wong, Johnson, R. PauL, Kimpel Janine, Braun Stephen E., Johnson R. Paul, Dropulic, Boro   +43 more
core   +2 more sources

Natural products as a source of Coronavirus entry inhibitors

Frontiers in Cellular and Infection Microbiology
The COVID-19 pandemic has had a significant and lasting impact on the world. Four years on, despite the existence of effective vaccines, the continuous emergence of new SARS-CoV-2 variants remains a challenge for long-term immunity.
Dávid Szabó, Dávid Szabó, Andrew Crowe, Andrew Crowe, Cyril Mamotte, Cyril Mamotte, Padraig Strappe, Padraig Strappe   +7 more
doaj   +1 more source

The use of viral RNA polymerase inhibitors in combination with a fusion inhibitor in the treatment of patients with COVID-19: hypothesis

Вопросы вирусологии, 2020
This review article considers the possibilities of combined antiviral therapy in the treatment of patients with COVID-19, based on the analysis of the mechanism of action of known antiviral drugs in the framework of the medical hypothesis.
O. V. Gaisenok
doaj   +1 more source

The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network [PDF]

, 2008
The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi–ER (endoplasmic reticulum) fusion ...
Amessou, M, Boal, Frédéric, Mohammed, Ludger, Roberts, LM, Stephens, David J, Smith, Daniel C., Clarkson, GJ, Stephens, D. J., Lord, JM, Clarkson, Guy J., Clarkson, Guy J, Roberts, Lynne M, Amessou, M., Watson, Peter D, Lord, J. M., Watson, Peter, Roberts, L. M. (Lynne M.), Amessou, Mohammed, Spooner, Robert A, Boal, F., Johannes, L., Smith, D. C., Smith, Daniel C, Clarkson, G. J., Spooner, Robert A., Stephens, David J., Watson, P, Smith, DC, Lord, J. Michael, Johannes, Ludger, Lord, Mike, Johannes, L, Spooner, RA, Boal, F, Stephens, DJ, Spooner, R. A., Watson, Peter Duncan, Roberts, L. M.   +37 more
core   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Development of potent pan‐coronavirus fusion inhibitors with a new design strategy

MedComm
Development of potent and broad‐spectrum drugs against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) remains one of the top priorities, especially in the cases of the emergence of mutant viruses and inability of current vaccines to prevent
Yuanmei Zhu, Zhongcai Gao, Xiaoli Feng, Lin Cheng, Nian Liu, Chao Liu, Shaowei Han, Qiaojiang Yang, Qingcui Zou, Huihui Chong, Zheng Zhang, Minghua Li, Gengshen Song, Yuxian He   +13 more
doaj   +1 more source

Fusion Inhibition of Zika Virus Entry by a Teicoplanin Pseudoaglycone Derivative with Broad Antiviral Activity

Pharmaceutics
Background/Objectives: The lack of effective antiviral therapies for many viral infections highlights the need for the development of new antiviral agents.
Zoltán Kopasz, Ilona Bereczki, Krisztina Leiner, Henrietta Papp, Eszter Boglárka Lőrincz, Levente Sipos-Szabó, Kornélia Bodó, Eszter Szabó, Mónika Madai, Brigitta Zana, Réka Erdei, Gyula Batta, Tamás Kovács-Öller, Zoltán Varga, Dávid Bajusz, Gábor Kemenesi, Anikó Borbás, Anett Kuczmog   +17 more
doaj   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source