Results 61 to 70 of about 1,959,868 (292)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A highly potent, stable, and safe dePEGylated lipopeptide against Nipah virus and related henipaviruses

Emerging Microbes and Infections
Nipah virus (NiV) poses a significant threat owing to its high mortality and the lack of approved therapeutics. Targeting the conserved heptad repeat 1 (HR1) domain of the viral fusion (F) protein constitutes a promising antiviral strategy.
Yuanzhou Wang, Cong Wang, Jie Zhou, Guangxu Zhang, Ruixue Xiu, Shuang Wu, Wei Xu, Mengyu Hu, Shuai Xia, Yuren Shi, Siyu Lin, Yuan Yin, Lu Lu, Yun Zhu, Shibo Jiang, Qian Wang   +15 more
doaj   +1 more source

Characterization of Potent Fusion Inhibitors of Influenza Virus

PLOS ONE, 2015
ISSN:1932 ...
Rowse, Michael, Qiu, Shihong, Tsao, Jun, Xian, Tongmei, Khawaja, Sarah, Yamauchi, Yohei, Yang, Zhen, Wang, Guoxin, Luo, Ming   +8 more
openaire   +7 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain

mBio, 2020
The emergence of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of the 2019 coronavirus disease (COVID-19), has erupted into a global pandemic that has led to tens of millions of infections and hundreds of ...
Victor K. Outlaw, Francesca T. Bovier, Megan C. Mears, Maria N. Cajimat, Yun Zhu, Michelle J. Lin, Amin Addetia, Nicole A. P. Lieberman, Vikas Peddu, Xuping Xie, Pei-Yong Shi, Alexander L. Greninger, Samuel H. Gellman, Dennis A. Bente, Anne Moscona, Matteo Porotto   +15 more
doaj   +1 more source

Geranylgeranylated Snares Are Dominant Inhibitors of Membrane Fusion [PDF]

The Journal of Cell Biology, 2000
Exocytosis in yeast requires the assembly of the secretory vesicle soluble N-ethylmaleimide–sensitive factor attachment protein receptor (v-SNARE) Sncp and the plasma membrane t-SNAREs Ssop and Sec9p into a SNARE complex. High-level expression of mutant Snc1 or Sso2 proteins that have a COOH-terminal geranylgeranylation signal instead of a ...
Eric Grote, Misuzu Baba, Yoshinori Ohsumi, Peter J. Novick   +3 more
openaire   +2 more sources

Mycobacterium Survival Strategy Translated to Develop a Lipo-Peptide Based Fusion Inhibitor [PDF]

, 2020
The entry of enveloped viruses requires fusion of viral and host cell membranes. An effective fusion inhibitor aiming at impeding such virus-host cell membrane fusion may emerge as a broad-spectrum antiviral agent to neutralize the infection from an ...
Amirul Islam, Mallick, Pradip Kumar, Tarafdar, Aritraa, Lahiri, Avijit, Sardar   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Addition of a short HIV-1 fusion-inhibitory peptide to PRO 140 antibody dramatically increases its antiviral breadth and potency

Journal of Virology
PRO 140, a humanized anti-HIV monoclonal antibody targeting the cell coreceptor CCR5, is currently under clinical trials, but it only affects CCR5-tropic viruses. In this study, we have engineered two tandem fusion proteins (2P23-PRO140SC and 2P23-PRO140-
Hongxia Yan, Yue Gao, Yuanmei Zhu, Huihui Chong, Yani Gong, Yue Chen, Li Li, Bin Su, Yuxian He   +8 more
doaj   +1 more source

Clinical perspective of fusion inhibitors for treatment of HIV [PDF]

Journal of Antimicrobial Chemotherapy, 2004
The number of antiretroviral-experienced HIV patients with multiple resistances against the currently available antiretroviral drug classes is increasing substantially. Therapeutic options for this specific group of patients are limited. The fusion inhibitor enfuvirtide represents the first new therapeutic option from a new drug class for this patient ...
J K, Rockstroh, S, Mauss
openaire   +2 more sources