Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement [PDF]
, 2000 G2A is an orphan G protein-coupled receptor (GPCR), expressed predominantly in T and B cells and homologous to a small group of GPCRs of unknown function expressed in lymphoid tissues.
Feramisco, Jamison D. +6 more
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Delivery as nanoparticles reduces imatinib mesylate-induced cardiotoxicity and improves anticancer activity [PDF]
, 2015 Clinical effectiveness of imatinib mesylate in cancer treatment is compromised by its off-target cardiotoxicity. In the present study, we have developed physically stable imatinib mesylate-loaded poly(lactide-co-glycolide) nanoparticles (INPs) that could
Balakumar, Krishnamoorthy +6 more
core +2 more sources
Novel prognostic factors in chronic myeloid leukemia [PDF]
, 2008 Chronic myeloid leukemia (CML) is a malignant clonal blood disease that originates from a pluripotent hematopoietic stem cell. The cytogenetic hallmark of CML, the Philadelphia chromosome (Ph), is formed as a result of reciprocal translocation between ...
Lundán, Tuija
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Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]
, 2003 Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Chen, Xiao +8 more
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Iatreia, 2014 Introduction: Chronic myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome (Ph), resulting from the balanced reciprocal translocation t(9;22)(q34;q11).
Aya Bonilla, Carlos Alberto +10 more
doaj
Activation of Phosphatidylinositol 3-Kinase in Cells Expressing abl Oncogene Variants [PDF]
, 1991 A phosphoinositide kinase specific for the D-3 position of the inositol ring, phosphatidylinositol (PI) 3-kinase, associates with activated receptors for platelet-derived growth factor, insulin, and colony-stimulating factor 1, with products of the ...
Baltimore, David +4 more
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Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer [PDF]
ACS Medicinal Chemistry Letters, 2020 openaire +2 more sources
Молекулярно-генетическая диагностика минимальной остаточной болезни в онкогематологии [PDF]
, 2014 лейкозГЕМАТОЛОГИЧЕСКИЕ НОВООБРАЗОВАНИЯГЕННАЯ ЭКСПРЕССИЯГЕНЕТИЧЕСКИЕ ...
Семенов, В. М. +1 more
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Binding of Vav to Grb2 through dimerization of Src homology 3 domains [PDF]
, 1994 The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation.
Baltimore, David, Ye, Zheng-Sheng
core
Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases
, 2016 B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusion of BCR exon 1 to ABL exon 3.
Lopez-Andrade, Bernardo +12 more
openaire +1 more source