Results 101 to 110 of about 21,002 (186)

Phosphorylation activity and specificity of the oncogenic tyrosine kinase fusion protein BCR/ABL

, 2021
Tyrosinphosphorylierung (pTyr) ist ein zentraler Bestandteil vieler zellulärer Signalpfade und ihre Deregulation führt zu Krebserkrankungen wie Leukämie. Kinase-Substrat-Annotation ist unerlässlich um das Krankheitsbild zu verstehen. Diese wird jedoch von Kinasenredundanz, Spezifitätsüberlappung und Aktivitätsdifferenzen erschwert.Das ...
openaire  

Biological aspects of mTOR in leukemia [PDF]

, 2018
The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival.
Bianchi, Mp, Gianfelici, V, Mirabilii, S, Piedimonte, M, Ricciardi, Mr, Tafuri, A.   +5 more
core   +1 more source

Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement [PDF]

, 2000
G2A is an orphan G protein-coupled receptor (GPCR), expressed predominantly in T and B cells and homologous to a small group of GPCRs of unknown function expressed in lymphoid tissues.
Feramisco, Jamison D., Gu, Jennifer L., Kabarowski, Janusz H. S., Le, Lu Q., Luoh, Shiuh-Wen, Simon, Melvin I., Witte, Owen N.   +6 more
core  

Detection of p190BCR-ABL AND p210BCR-ABL fusion transcripts in patients with chronic myeloid leukemia (CML) using qualitative RT-PCR

Iatreia, 2014
Introduction: Chronic myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome (Ph), resulting from the balanced reciprocal translocation t(9;22)(q34;q11).
Aya Bonilla, Carlos Alberto , Domingo Torres, José , Muskus, Carlos Enrique, Ramírez Gaviria, Gloria , Cuervo Sierra, Jorge , Sierra Sánchez, Margarita , Cuéllar-Ambrosi, Francisco , Botero Garcés, Jorge Humberto, Gloria Artigas A., Carmen , Muñetón, Carlos Mario , Vásquez Palacio, Gonzalo   +10 more
doaj  

Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer [PDF]

ACS Medicinal Chemistry Letters, 2020
openaire   +2 more sources

Activation of Phosphatidylinositol 3-Kinase in Cells Expressing abl Oncogene Variants [PDF]

, 1991
A phosphoinositide kinase specific for the D-3 position of the inositol ring, phosphatidylinositol (PI) 3-kinase, associates with activated receptors for platelet-derived growth factor, insulin, and colony-stimulating factor 1, with products of the ...
Baltimore, David, Cantley, Lewis C., Daley, George Q., Jackson, Peter, Varticovski, Lyuba   +4 more
core  

Молекулярно-генетическая диагностика минимальной остаточной болезни в онкогематологии [PDF]

, 2014
лейкозГЕМАТОЛОГИЧЕСКИЕ НОВООБРАЗОВАНИЯГЕННАЯ ЭКСПРЕССИЯГЕНЕТИЧЕСКИЕ ...
Семенов, В. М., Шляхтунов, Е. А.   +1 more
core  

Binding of Vav to Grb2 through dimerization of Src homology 3 domains [PDF]

, 1994
The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation.
Baltimore, David, Ye, Zheng-Sheng
core  

Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases

, 2016
B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusion of BCR exon 1 to ABL exon 3.
Lopez-Andrade, Bernardo, Gutierrez, Antonio, Garcia, Lucia, Cunill, Vanesa, Duran Pastor, Maria Antonia, Sampol Mayol, Antonia, Bernues, Marta, Iglesias, Julio, Ramos-Asensio, Rafael, Llado, Josep, Sanchez, Maria, Carlos Amat, Juan, Martinez-Serra, Jordi   +12 more
openaire   +1 more source

Abstracts of the 18th SCWD Conference, 11‐13 December 2025 in Rome/Italy

JCSM Communications, Volume 9, Issue 1, January/June 2026.
wiley   +1 more source