Results 101 to 110 of about 9,645 (157)

Phosphorylation activity and specificity of the oncogenic tyrosine kinase fusion protein BCR/ABL

, 2021
Tyrosinphosphorylierung (pTyr) ist ein zentraler Bestandteil vieler zellulärer Signalpfade und ihre Deregulation führt zu Krebserkrankungen wie Leukämie. Kinase-Substrat-Annotation ist unerlässlich um das Krankheitsbild zu verstehen. Diese wird jedoch von Kinasenredundanz, Spezifitätsüberlappung und Aktivitätsdifferenzen erschwert.Das ...
openaire  

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Metabolic gatekeeper function of B-lymphoid transcription factors. [PDF]

, 2017
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development, yet lesions of the genes encoding these transcription factors occur in over 80% of cases of pre-B-cell acute lymphoblastic leukaemia (ALL).
Borkhardt, Arndt, Braas, Daniel, Cazzaniga, Giovanni, Cazzaniga, Valeria, Chan, Lai N, Chen, Zhengshan, Cosgun, Kadriye Nehir, Dickins, Ross A, Ernst, Thomas, Geng, Huimin, Graeber, Thomas G, Hochhaus, Andreas, Hurtz, Christian, Koeffler, H Phillip, Konopleva, Marina, Kornblau, Steven M, Lee, Jae-Woong, Liu, Grace J, Milne, Thomas A, Müschen, Markus, Pufall, Miles A, Ross, Theodora S, Schjerven, Hilde, Shojaee, Seyedmehdi, Sánchez-García, Isidro, Xiao, Gang, Yamamoto, Keith R   +26 more
core  

Targeting CDK6 and BCL2 Exploits the MYB Addiction of Ph+ Acute Lymphoblastic Leukemia [PDF]

, 2018
Philadelphia chromosome–positive acute lymphoblastic leukemia (Phþ ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with chemotherapy. However, most patients develop resistance to TKI through BCR-ABL1–dependent and –
Addya, Sankar, Calabretta, Bruno, De Dominici, Marco, Ferrari, Anna, Fortina, Paolo, Iacobucci, Ilaria, Mariani, Samanta A., Martinelli, Giovanni, Peterson, Luke F., Porazzi, Patrizia, Rambaldi, Alessandro, Soliera, Angela Rachele, Spinelli, Orietta   +12 more
core   +1 more source

Novel prognostic factors in chronic myeloid leukemia [PDF]

, 2008
Chronic myeloid leukemia (CML) is a malignant clonal blood disease that originates from a pluripotent hematopoietic stem cell. The cytogenetic hallmark of CML, the Philadelphia chromosome (Ph), is formed as a result of reciprocal translocation between ...
Lundán, Tuija
core  

Flow cytometric detection of BCR-ABL fusion proteins in leukemia patients via an immunobead assay

, 2011
Peer ...
Weerkamp, F., Flores-Montero, Juan, Orfao, Alberto   +2 more
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Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

Poster Sessions

HemaSphere, Volume 9, Issue S1, June 2025.
wiley   +1 more source

MOLECULAR CHARACTERIZATION OF DIFFERENT GENE FUSIONS ASSOCIATED WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN FROM THE BRAZILIAN AMAZON

Hematology, Transfusion and Cell Therapy
Objective: Acute Lymphoblastic Leukemia (ALL) is classified according to its genetic abnormalities, which are associated with the clinical and biological characteristics of the disease.
MB Oliveira, ATM Tavares, LB Rotella, MS Aquino, KVM Queiroz, EJC Botelho, FMCP Pessoa, AV Wanderley, CA Moreira-Nunes, AS Khayat   +9 more
doaj  

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment] [PDF]

Blood, 1996
openaire   +2 more sources