Results 81 to 90 of about 11,727 (181)

Synthetic peptide analogs derived from bcr/abl fusion proteins and the induction of heteroclitic human T-cell responses.

Haematologica, 2006
Chronic myelogenous leukemia (CML) presents a unique opportunity to develop therapeutic strategies using vaccination against a truly tumor-specific antigen that is also the oncogenic protein required for neoplasia. We have shown in phase I and II trials that a tumor-specific, bcr-abl-derived peptide vaccine can be safely administered to patients with ...
Javier, Pinilla-Ibarz, Tatyana, Korontsvit, Victoriya, Zakhaleva, Wendy, Roberts, David A, Scheinberg   +4 more
openaire   +1 more source

Flow cytometric detection of BCR-ABL fusion proteins in leukemia patients via an immunobead assay

, 2011
Peer ...
Weerkamp, F., Flores-Montero, Juan, Orfao, Alberto   +2 more
openaire   +1 more source

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment] [PDF]

Blood, 1996
openaire   +1 more source

Anti-tumor Activity of Novel Compounds Targeting BCR-ABL, c-SRC and BCR-ABLT315I in Chronic Myelogenous Leukemia [PDF]

, 2013
Chronic myelogenous leukemia (CML) is a hematological stem-cell disorder characterized by the expression of the BCR-ABL fusion protein, a constitutively active tyrosine kinase that causes pathogenesis. The development of tyrosine kinase inhibitors (TKIs)
Vivier, Sophie, Loget, Olivier, Daydé-Cazals, Bénédicte, Auberger, Patrick, Boriès, Cédric, Coisy-Quivy, Marjorie, Feneyrolles, Clémence, Bestgen, Benoît, Delon, Louis, Dufies, Maeva, Fauvel, Bénédicte, Chevé, Gwénaël, Yasri, Aziz   +12 more
core  

Optimizing immunity against BCR-ABL positive leukemia

, 2003
Chronic myelogenous leukemia (CML) is a clonal disorder characterized by proliferation of cells expressing BCR-ABL fusion proteins. The BCR-ABL fusion proteins are tumor-specific antigens and represent reasonable targets for immunologic approaches ...
Zeng, Yi
core  

Impact of BCR -ABL on DNA repair

, 2001
The BCR-ABL fusion gene is the molecular hallmark of Philadelphia-positive leukemias. Normal Bcr is a multifunctional protein, originally localized to the cytoplasm.
Laurent, Eunice
core  

Fusion oncoproteins orchestrate tumorigenesis and sustain malignant progression via a positive feedback mechanism. [PDF]

Cell Biosci
Ying W, Wang X, Yu J, Wang J, He Q, Yang B, Chen Y, Ying M.   +7 more
europepmc   +1 more source

Identification of a <i>Musashi2</i> translocation as a novel oncogene in myeloid leukemia. [PDF]

Elife
Spinler K, Hamilton M, Bajaj J, Shima Y, Diaz E, Kritzik M, Reya T.   +6 more
europepmc   +1 more source

Control of DNA replication by NCOA4 protein in HeLa cells

, 2009
This dissertation is focused on the functional characterization of NCOA4 protein, and in particular on its role in controlling DNA replication in HeLa cells.
Provitera, Livia
core  

Proximity-Induced Rewiring of Oncogenic Kinase Triggers Apoptosis. [PDF]

ACS Cent Sci
Merz ML, Shoba VM, Pergu R, Severance ZC, Munkanatta Godage DNP, Deb A, Kwok HS, Singh P, Singh S, Allen JB, Tian W, Gosavi PM, Chaudhary SK, Anokhina V, Weisberg EL, Payne NC, He Y, Dhaliwal R, Osadchey R, Shekhar M, Mazitschek R, Rees MG, Roth JA, Cui Q, Griffin JD, Liau BB, Choudhary A.   +26 more
europepmc   +1 more source