Results 61 to 70 of about 11,727 (181)
Elucidating the role of the tumor suppressor Protein Phoshatase 2A in Chronic Myeloid Leukemia.
, 2010 Protein phosphatase-2A (PP2A) is one of the major cellular serine-threonine phosphatases and is involved in the regulation of cell homeostasis through the negative regulation of signaling pathways initiated by protein kinases.
Neviani, Paolo
core
, 2003 Mitogen activated protein kinases (MAPKs) are found in all eukaryotic cells and represent crucial elements in the signal transduction from the plasma membrane to the nucleus.
Buschbeck, Marcus
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Ultra-deep mutational analysis of NPM-ALK and possible implications on target therapy in anaplastic large cell lymphoma of childhood [PDF]
, 2013 Anaplastic Large Cell Lymphoma (ALCL) represents a distinct subset of aggressive T-cell non-Hodgkin lymphoma (NHL) accounting for about 3% of adult NHL and 10 to 15% of childhood lymphomas.
Lovisa, Federica
core
, 2007 New, potentially tumor-specific antigens have been described in Bcr/Abl positive leukemias. Besides the main BCR/ABL hybrid fusion transcripts, a small number of transcripts derived from alternative splicing between BCR exons 1, 13, and 14 with ABL exons
G. Tarone +18 more
core +1 more source
Iatreia, 2014 Introduction: Chronic myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome (Ph), resulting from the balanced reciprocal translocation t(9;22)(q34;q11).
Aya Bonilla, Carlos Alberto +10 more
doaj
Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer [PDF]
ACS Medicinal Chemistry Letters, 2020 openaire +2 more sources
BCR: a promiscuous fusion partner in hematopoietic disorders [PDF]
, 2019 Considerable advances have been made in our understanding of the molecular basis of hematopoietic cancers. The discovery of the BCR-ABL fusion protein over 50 years ago has brought about a new era of therapeutic progress and overall improvement in ...
Li, Fangda +2 more
core +1 more source
Autocrine secretion of osteopontin results in degradation of I kappa B in Bcr-Abl-expressing cells
, 2005 Osteopontin has been identified as a marker of metastasis formation and its increased expression has been correlated with the malignancy of cancer. In this study we provide evidence that increased expression of osteopontin may also be associated with ...
core +1 more source
A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL
, 2020 Targeted protein degradation (TPD) and proteolysis-targeting chimeras (PROTACs) have arisen as powerful therapeutic modalities for degrading specific protein targets in a proteasome-dependent manner.
Tong, Bingqi +12 more
core +1 more source
Dissecting BCR-ABL Variant Signaling Pathways Using Novel Interactome Identification Strategies [PDF]
, 2019 Cell signaling is an essential function of cells and tissues. Understanding cell signaling necessitates technologies that can identify protein-protein interactions as well as post translational modifications to proteins within protein complexes.
Cutler, Jevon A
core