Results 61 to 70 of about 11,258 (167)

Роль домену РН білка BCR у клітинних процесах, що визначають фенотип ph`-позитивних мієлопроліферативних захворюваннях

Фактори експериментальної еволюції організмів, 2014
Aims. Three forms of fusion protein BCR/ABL differ by the presence or absence of PH and DH domains of BCR protein and cause different phenotypes of myeloproliferative disorders.
Д. С. Гур’янов, Т. Ю. Лисецька, С. В. Антоненко, І. В. Кравчук, Г. Д. Телегєєв   +4 more
doaj  

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, Volume 4, Issue 2, Page 91-107, June 2026.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Durable MRD‐Negative Remission With Blinatumomab and Venetoclax in Heavily Pretreated Relapsed/Refractory Philadelphia Chromosome‐Positive Acute Lymphoblastic Leukemia

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Introduction Tyrosine kinase inhibitors (TKIs) are standard therapy for Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL); however, relapsed or refractory disease remains challenging due to resistance driven by ABL kinase domain mutations.
Mohammad Shahzaib Qadir, Shereen Farooq, Omer Jamy   +2 more
wiley   +1 more source

Acute lymphoblastic leukemia with e1A3 BCR-ABL fusion protein: report of 2 cases and literature review

Di-san junyi daxue xuebao, 2021
Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ hybridization (FISH) and real-time fluorescence quantitative PCR of 2 ALL cases with e1a3 BCR-ABL ...
CHEN Siyu, DENG Xiaojuan, ZHANG Yuwei, GOU Yang, ZHANG Xi, PENG Xiangui, WANG Ping   +6 more
openaire   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript

Pakistan Journal of Medicine and Dentistry
Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes ...
Najia Tabassum, Rubina Ghani, Mohammad Saboor, Moinuddin Moinuddin   +3 more
doaj  

MOLECULAR CHARACTERIZATION OF DIFFERENT GENE FUSIONS ASSOCIATED WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN FROM THE BRAZILIAN AMAZON

Hematology, Transfusion and Cell Therapy
Objective: Acute Lymphoblastic Leukemia (ALL) is classified according to its genetic abnormalities, which are associated with the clinical and biological characteristics of the disease.
MB Oliveira, ATM Tavares, LB Rotella, MS Aquino, KVM Queiroz, EJC Botelho, FMCP Pessoa, AV Wanderley, CA Moreira-Nunes, AS Khayat   +9 more
doaj   +1 more source

Integrating dual convolutional networks and BiLSTM for precision prediction of chronic myeloid leukemia from protein sequences

Frontiers in Genetics
IntroductionChronic Myeloid Leukemia (CML) is a hematologic malignancy characterized by the occurrence of the Philadelphia chromosome [t(9; 22)(q34; q11)], leading to the creation of the BCR–ABL fusion gene.
Hend Khalid Alkahtani, Ayman Qahmash
doaj   +1 more source

Detection of p190BCR-ABL AND p210BCR-ABL fusion transcripts in patients with chronic myeloid leukemia (CML) using qualitative RT-PCR

Iatreia, 2014
Introduction: Chronic myelogenous leukemia (CML) is characterized by the presence of the Philadelphia chromosome (Ph), resulting from the balanced reciprocal translocation t(9;22)(q34;q11).
Aya Bonilla, Carlos Alberto , Domingo Torres, José , Muskus, Carlos Enrique, Ramírez Gaviria, Gloria , Cuervo Sierra, Jorge , Sierra Sánchez, Margarita , Cuéllar-Ambrosi, Francisco , Botero Garcés, Jorge Humberto, Gloria Artigas A., Carmen , Muñetón, Carlos Mario , Vásquez Palacio, Gonzalo   +10 more
doaj  

Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer [PDF]

ACS Medicinal Chemistry Letters, 2020
openaire   +2 more sources