Results 71 to 80 of about 11,727 (181)

Immunocytochemical study of BCR and bcr-abl localization in K562 cells

, 2010
Aim: To obtain polyclonal antibodies against recombinant proteins recognizing Bcr domain and fusion region of Bcr-Abl and analyze the patterns of intracellular distribution of Bcr and Bcr-Abl proteins in K562 cells of chronic myelogenous leukemia ...
Telegeev, G.D., Zavelevich, M.P., Nadgorna, V.A., Maliuta, S.S., Dubrovska, A.N., Gluzman, D.F., Dybkov, M.V.   +6 more
core   +1 more source

Phosphorylation activity and specificity of the oncogenic tyrosine kinase fusion protein BCR/ABL

, 2021
Tyrosinphosphorylierung (pTyr) ist ein zentraler Bestandteil vieler zellulärer Signalpfade und ihre Deregulation führt zu Krebserkrankungen wie Leukämie. Kinase-Substrat-Annotation ist unerlässlich um das Krankheitsbild zu verstehen.
Smolnig, Martin
core  

Role of SOCS proteins in FLT3-ITD and BCR/ABL mediated leukemogenesis

, 2010
Acute myeloid/lymphoid leukemia is a fatal hematological malignancy characterized by accumulation of nonfunctional, immature blasts, which interferes with the production of normal blood cells.
Reddy, N. G. Pavan Kumar
core  

Apoptosis and mitotic slippage following drug intervention in leukaemia cells

, 2011
PhDThe response of leukaemia cells to therapeutic agents includes cell cycle arrest and apoptosis. The former response is useful in retarding disease progression, but induction of the latter is essential for disease eradication.
Omar, Najood Amer
core  

J Registry Manag [PDF]

IntroductionNational and International Hematology/Oncology Practice Guidelines recommend testing for the BCR-ABL mutation for definitive diagnosis of chronic myeloid leukemia (CML) to allow for appropriate treatment with a Tyrosine Kinase Inhibitor (TKI).

core  

Inhibition of Bcr-Abl oncogene expression by RNA interference

, 2014
Die Aktivität der Bcr-Abl-Tyrosinkinase (Bcr-Abl-TK) ist die molekulare Ursache für die Entwicklung der Chronisch Myeloischen Leukämie (CML). Bei der Akuten Lymphatischen Leukämie (ALL) bedeutet das Vorhandensein des Philadelphia-Chromosoms und damit die
Wohlbold, Lara
core   +1 more source

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome positive Acute Lymphatic Leukemia

, 2014
The successful targeting of BCR/ABL by selective ABL-kinase inhibitors (AKI) such as Imatinib, Nilotinib, or Dasatinib alone is unable to eradicate the leukemic clone in Philadelphia chromosome positive (Ph+ ) leukemia. The t(9;22)(q34;q11) is a balanced
Ruthardt, Martin, Oancea, Claudia, Mian, Afsar, Ottmann, Oliver, Rafiei, Anahita   +4 more
core  

Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders [PDF]

, 2009
The myeloproliferative disorders (MPDs) are a group of haematopoietic stem cell diseases, characterised by proliferation of one or more cells of the myeloid lineage.
Hidalgo-Curtis, Claire
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Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases

, 2016
B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusion of BCR exon 1 to ABL exon 3.
Lopez-Andrade, Bernardo, Gutierrez, Antonio, Garcia, Lucia, Cunill, Vanesa, Duran Pastor, Maria Antonia, Sampol Mayol, Antonia, Bernues, Marta, Iglesias, Julio, Ramos-Asensio, Rafael, Llado, Josep, Sanchez, Maria, Carlos Amat, Juan, Martinez-Serra, Jordi   +12 more
openaire   +1 more source

Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571

, 2003
Translocations involving the abl locus on chromosome 9 fuses the tyrosine kinase c-ABL to proteins harboring oligomerization interfaces such as BCR or TEL, enabling these ABL-fusion proteins (X-ABL) to transform cells and to induce leukemia.
Bianchini, Andrea, Hoelzer, Dieter, T. Beissert, D. Hoelzer, Ruthardt, Martin, NERVI, Clara, Boehrer, Simone, M. Ruthardt, S. Boehrer, Puccetti, Elena, E. Puccetti, A. Bianchini, Beissert, Tim, Ottmann, Oliver Gerhard, Güller, Saskia, O. Gerhard Ottmann, S. Gller   +16 more
core   +1 more source