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Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript

Pakistan Journal of Medicine and Dentistry
Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes ...
Najia Tabassum, Rubina Ghani, Mohammad Saboor, Moinuddin Moinuddin   +3 more
doaj  

Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia [PDF]

, 2001
Chronic myeloid leukemia (CML) is characterized by formation of the BCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22.
Reid, AG, Campbell, LJ, Telford, N, Grace, C, Nacheva, EP, Shepherd, P, Szer, J, Green, AR, Bench, AJ, Prince, HM, Huntly, BJP, Turner, P   +11 more
core  

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Breakthrough in Degradation of BCR-ABL Fusion Protein for the Treatment of Cancer [PDF]

ACS Medicinal Chemistry Letters, 2020
openaire   +2 more sources

Importância da investigação da mutação JAK2V617F em pacientes com neoplasia mieloproliferativa crônica BCR/ABL negativa e sua associação com a expressão da proteína antiapoptótica survivina como marcador diagnóstico [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011As neoplasias mieloproliferativas crônicas (NMPC) são neoplasias originadas por uma proliferação ...
Barcelos, Michelle Maccarini
core  

MOLECULAR CHARACTERIZATION OF DIFFERENT GENE FUSIONS ASSOCIATED WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN FROM THE BRAZILIAN AMAZON

Hematology, Transfusion and Cell Therapy
Objective: Acute Lymphoblastic Leukemia (ALL) is classified according to its genetic abnormalities, which are associated with the clinical and biological characteristics of the disease.
MB Oliveira, ATM Tavares, LB Rotella, MS Aquino, KVM Queiroz, EJC Botelho, FMCP Pessoa, AV Wanderley, CA Moreira-Nunes, AS Khayat   +9 more
doaj   +1 more source

The regulation of bcr-abl in hypoxia is through the mTOR pathway

, 2020
Chronic myeloid leukemia (CML) is usually characterized by the formation of the fusion onco-protein bcr-abl. Therefore, the majority of CML treatments are bcr-abl specific tyrosine kinase inhibitors (TKIs).
Di Trapani, Giovanna, Clapper, Erin, Tonissen, Kathryn F   +2 more
core   +1 more source

Role of SOCS proteins in FLT3-ITD and BCR/ABL mediated leukemogenesis [PDF]

, 2010
Acute myeloid/lymphoid leukemia is a fatal hematological malignancy characterized by accumulation of nonfunctional, immature blasts, which interferes with the production of normal blood cells.
Reddy, N. G. Pavan Kumar
core  

Integrating dual convolutional networks and BiLSTM for precision prediction of chronic myeloid leukemia from protein sequences

Frontiers in Genetics
IntroductionChronic Myeloid Leukemia (CML) is a hematologic malignancy characterized by the occurrence of the Philadelphia chromosome [t(9; 22)(q34; q11)], leading to the creation of the BCR–ABL fusion gene.
Hend Khalid Alkahtani, Ayman Qahmash
doaj   +1 more source

Synthetic peptide analogs derived from bcr/abl fusion proteins and the induction of heteroclitic human T-cell responses

Haematologica, 2005
BACKGROUND AND OBJECTIVES: Chronic myelogenous leukemia (CML) presents a unique opportunity to develop therapeutic strategies using vaccination against a truly tumor-specific antigen that is also the oncogenic protein required for neoplasia.
J Pinilla-Ibarz, T Korontsvit, V Zakhaleva, W Roberts, DA Scheinberg   +4 more
doaj