Results 51 to 60 of about 11,727 (181)

Eosinofilia reacional, leucemia eosinofílica crônica e síndrome hipereosinofílica idiopática Reactive eosinophilia, chronic eosinophilic leukemia and idiopathic hypereosinophilic syndrome

Revista Brasileira de Hematologia e Hemoterapia, 2010
A eosinofilia é freqüente na prática clínica, principalmente quando os valores estão entre 500 e 1000 eosinófilos/uL e indica a presença de doença parasitária, alérgica ou reação a medicamentos.
Maria de Lourdes Lopes Ferrari Chauffaille
doaj   +1 more source

Differential Signaling through p190 and p210 Forms of BCR-ABL Fusion Proteins Revealed By Proteomic Analysis

Blood, 2015
Abstract Chromosomal translocations involving chromosome 9q34 and 22q11 generate the BCR-ABL1 fusion gene. The location of the translocation within the BCR gene dictates which exons are excluded or included in the resulting fusion with the ABL1 gene.
Jevon Cutler, Rahia Tahir, Jingnan Han, Raja Sekhar Nirujogi, Tai-Chung Huang, Xianrong Wong, Saradhi Mallampati, Xiaoping Sun, Patrick Brown, Karen Reddy, Akhilesh Pandey   +10 more
openaire   +1 more source

STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis [PDF]

, 2012
In chronic myeloid leukemia (CML), the BCR-ABL fusion oncoprotein activates multiple pathways involved in cell survival, growth promotion and disease progression.
Kanakura, Y., Yoshimura, A., Sekine, Y., Ikeda, O., Ueno, Y., Mizushima, A., Muromoto, R., Oritani, K., Matsuda, T.   +8 more
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Specific Monoclonal Antibody Against Bcr/Abl Out-of-Frame Alternative Proteins as Diagnostic Tool in Chronic Myelogenous Leukemia Patients [PDF]

, 2017
More recently, alternative splicing of specific genes are investigated for their therapeutic potential. In particular, we reported the existence of BCR-ABL alternative splicing isoforms, in about 80% of Philadelphia-positive patients, which lead to the ...
Mesiano G., Marelli O., Panuzzo C., Volpe G., Crotta K., Saglio G., Lattuada D., Casnici C.   +7 more
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Importância da investigação da mutação JAK2V617F em pacientes com neoplasia mieloproliferativa crônica BCR/ABL negativa e sua associação com a expressão da proteína antiapoptótica survivina como marcador diagnóstico [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011As neoplasias mieloproliferativas crônicas (NMPC) são neoplasias originadas por uma proliferação ...
Barcelos, Michelle Maccarini
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Acute lymphoblastic leukemia with e1A3 BCR-ABL fusion protein: report of 2 cases and literature review

Di-san junyi daxue xuebao, 2021
Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ hybridization (FISH) and real-time fluorescence quantitative PCR of 2 ALL cases with e1a3 BCR-ABL ...
CHEN Siyu, DENG Xiaojuan, ZHANG Yuwei, GOU Yang, ZHANG Xi, PENG Xiangui, WANG Ping   +6 more
openaire   +1 more source

Neue Ansätze des molekularen Targetings bei der Philadelphia-Chromosom-positiven Leukämie

, 2011
In Philadelphia Chromosome (Ph) positive ALL and CML the fusion between BCR and ABL leads to the BCR/ABL fusion proteins, which induces the leukemic phenotype because of the constitutive activation of multiple signaling pathways down-stream to the ...
Mian, Afsar Ali
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New Bcr-Abl-independent mechanisms of resistance to imatinib treatment in chronic myelogenous leukaemia patients

, 2008
Although rare in chronic phase myeloid leukemia (CML), primary or acquired resistance to the treatment with tyrosine kinase inhibitors (TKI) may be observed in the advanced phases of disease.
Esposito, Nicola
core  

MOLECULAR CHARACTERIZATION OF DIFFERENT GENE FUSIONS ASSOCIATED WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN FROM THE BRAZILIAN AMAZON

Hematology, Transfusion and Cell Therapy
Objective: Acute Lymphoblastic Leukemia (ALL) is classified according to its genetic abnormalities, which are associated with the clinical and biological characteristics of the disease.
MB Oliveira, ATM Tavares, LB Rotella, MS Aquino, KVM Queiroz, EJC Botelho, FMCP Pessoa, AV Wanderley, CA Moreira-Nunes, AS Khayat   +9 more
doaj   +1 more source

Unravelling the mechanisms of resistance to imatinib mesylate in chronic myeloid leukemia: a proteomic approach

, 2010
Imatinib mesylate is a potent inhibitor of the Bcr-Abl tyrosine kinase, an oncoprotein that plays a key role in the development of chronic myeloid leukemia. Consequently, imatinib is used as front-line therapy for this disease.
Colavita, Irene
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