Results 131 to 140 of about 9,645 (157)

The BCR-ABL Fusion Protein Sensitizes Acute Lymphoblastic Leukemia to Apoptotic Death Induced by the Dual Glycolytic and Glycosylation Inhibitor 2-Deoxy-D-Glucose.

Blood, 2012
Abstract Abstract 2439 Tumor metabolism has emerged as a hallmark of cancer by which the oncogenic profile of cancer cells pairs energy availability with cell growth and survival. BCR-ABL positive acute lymphoblastic leukemia (BCR-ABL+ ALL) is a highly resistant phenotype, and the BCR-ABL fusion protein has been correlated
Jianfeng Du, Julio C. Barredo, Gilles M. Leclerc, Guy J. Leclerc, Joanna DeSalvo   +4 more
openaire   +2 more sources

Alternative BCR/ABL Splice Variants in Philadelphia Chromosome–Positive Leukemias Result in Novel Tumor-Specific Fusion Proteins that May Represent Potential Targets for Immunotherapy Approaches

Cancer Research, 2007
Abstract Imatinib currently represents the standard treatment in the early chronic phase of chronic myelogenous leukemia (CML), thanks to the high percentage of cytogenetic complete remission achieved, but it is yet unclear to what extent it can eradicate leukemia.
Volpe G, Cignetti A, Panuzzo C, Kuka M, Vitaggio K, Brancaccio M, Perrone G, Rinaldi M, Prato G, Fava M, Geuna M, Pautasso M, Casnici C, Signori E, Tonon G, Tarone G, Marelli O, Fazio VM, Saglio G   +18 more
openaire   +7 more sources

[Construction and expression of a vector containing protein transduction domain and bcr/abl fusion gene].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2002
To construct a vector containing protein transduction domain (PTD) and bcr/abl fusion gene of chronic myelogenous leukemia and express PTD-bcr/abl fusion protein in E. Coli.DNA fragment encoding PTD was synthesized and fused to PCR-amplified bcr/abl gene fragment, then inserted into plasmid pET-16b to get the expression vector pEPb containing PTD-bcr ...
Yingmin, Liang, Qiang, Sun, Shanshan, Jiang, Jizhu, Wang, Rongli, Wu, Ping, Chen, Li, Liu, Hua, Han   +7 more
openaire   +1 more source

Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia.

Leukemia, 1993
Blast cells from an unselected consecutive series of 84 adults presenting with acute lymphoblastic leukemia (ALL) to St Bartholomew's Hospital over a seven year period were tested prospectively by cytogenetic and retrospectively by RT-PCR analysis for the presence of the Ph translocation and bcr-abl mRNA. This combination gave an overall figure of 20.3%
A, Tuszynski, S, Dhut, B D, Young, T A, Lister, A Z, Rohatiner, J A, Amess, T, Chaplin, E, Dorey, B, Gibbons   +8 more
openaire   +1 more source

Burning plasma achieved in inertial fusion

Nature, 2022
H W Herrmann, V Geppert-kleinrath, J M Koning   +2 more
exaly  

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Nature, 2020
Steven J Gamblin, Antoni G Wrobel, Donald J Benton   +2 more
exaly  

[Signal transduction BCR-ABL fusion protein: analysis of BCR-ABL functional domains].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 1998
T, Tauchi, S, Okabe, K, Oyashiki, K, Sotoyama   +3 more
openaire   +1 more source

Translating cancer genomes and transcriptomes for precision oncology

Ca-A Cancer Journal for Clinicians, 2016
Sameek Roychowdhury, Arul M Chinnaiyan
exaly  

Recent progress in the understanding, diagnosis, and treatment of gastroenteropancreatic neuroendocrine tumors

Ca-A Cancer Journal for Clinicians, 2011
Kiran K Turaga
exaly  

SNAREs — engines for membrane fusion

Nature Reviews Molecular Cell Biology, 2006
Reinhard Jahn
exaly