Results 131 to 140 of about 19,722 (182)

Allele-Specific PCR for Detection of Missense Mutations in the Chimeric <i>BCR::ABL1</i> Gene Causing Failure of Tyrosine Kinase Inhibitor Therapy in CML Patients. [PDF]

Int J Mol Sci
Skripkina A, Fevraleva I, Kuzmina E, Biderman B, Stepanova E, Chelysheva E, Turkina A, Sudarikov A.   +7 more
europepmc   +1 more source

Ubiquitin-specific proteases (USPs) in leukemia: a systematic review. [PDF]

BMC Cancer
Zangooie A, Tavoosi S, Arabhosseini M, Halimi A, Zangooie H, Baghsheikhi AH, Rahgozar S, Ahmadvand M, Jarrahi AM, Salehi Z.   +9 more
europepmc   +1 more source

Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells. [PDF]

Mol Cancer
Zeng C, Nie D, Wang X, Zhong S, Zeng X, Liu X, Qiu K, Peng X, Zhang W, Chen S, Zha X, Chen C, Chen Z, Wang W, Li Y.   +14 more
europepmc   +1 more source

Synthetic peptide analogs derived from bcr/abl fusion proteins induce heteroclitic human T cell responses.

Haematologica, 2006
openaire   +1 more source

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Characterization of a Monoclonal Antibody Specific for Novel Bcr/Abl Out-of-Frame Fusion Proteins

Hybridoma, 2011
The new tumor-specific antigens Bcr/Abl-OOF, identified in Philadelphia chromosome (Ph)-positive leukemia cells, are derived from an alternative splicing event involving BCR exons 1, 13, or 14 and ABL exons 4 and 5. The COOH-terminus of these transcription products contain an amino acid portion derived from an out-of-frame (OOF) reading of the ABL gene;
Casnici C, VOLPE, Gisella, Crotta K, PANUZZO, Cristina, Lattuada D, Cabras CA, Longhi R, SAGLIO, Giuseppe, Marelli O.   +8 more
openaire   +6 more sources

Detection of BCR-ABL fusion proteins in patients with leukemia using a cytometric bead array

Leukemia & Lymphoma, 2011
Rapid and accurate detection of BCR-ABL fusion proteins is vital for the diagnosis and classification of leukemias, especially chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Recently, the cytometric bead array (CBA) system has been used to identify BCR-ABL proteins in leukemic cell lysates.
Li Jianyong, Zhu Yu, Wang Li, Liu Peng, Zhang Sujiang, Wu Yujie, Qian Sixuan, Ge Zeng   +7 more
openaire   +4 more sources

Differential signaling through p190 and p210 BCR-ABL fusion proteins revealed by interactome and phosphoproteome analysis

Leukemia, 2017
Two major types of leukemogenic BCR-ABL fusion proteins are p190BCR-ABLand p210BCR-ABL. Although the two fusion proteins are closely related, they can lead to different clinical outcomes. A thorough understanding of the signaling programs employed by these two fusion proteins is necessary to explain these clinical differences.
Mohammad Heydarian, Akhilesh Pandey, Chris J. Mitchell, Santosh Renuse, Min-Sik Kim, Min-Sik Kim, X. Wong, Karen L. Reddy, Sreelakshmi K. Sreenivasamurthy, Xinyan Wu, Arun H. Patil, Arun H. Patil, Tai-Chung Huang, Tai-Chung Huang, Jevon Cutler, Raiha Tahir, Raja Sekhar Nirujogi   +16 more
openaire   +4 more sources

An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation

Leukemia Research, 2008
We have developed a simplified sandwich immunoassay to measure free circulating total and phosphorylated fusion BCR-ABL protein in patients with the t(9;22)(q34;q11) chromosomal translocation. The assay is based on immunoprecipitating BCR-ABL protein using beads coated with anti-BCR antibody and detecting the fusion protein with anti-ABL antibody and ...
Iman Jilani, Oliver G. Ottmann, Maher Albitar, Susan O'Brien, Mercedes E. Gorre, Homan Faraji, Hagop M. Kantarjian, Jorge E. Cortes, Francis J. Giles, Kapil N. Bhalla   +9 more
openaire   +3 more sources