Results 61 to 70 of about 979,221 (350)

The Acidic Tail of the Cdc34 Ubiquitin-conjugating Enzyme Functions in Both Binding to and Catalysis with Ubiquitin Ligase SCFC^(dc4*) [PDF]

, 2009
Ubiquitin ligases, together with their cognate ubiquitin-conjugating enzymes, are responsible for the ubiquitylation of proteins, a process that regulates a myriad of eukaryotic cellular functions. The first cullin-RING ligase discovered, yeast SCF^(Cdc4)
Bing Hao, Block, Cardozo, Creighton, Dane A. Mohl, Das, Deshaies, Dye, Eletr, Feldman, Frescas, Gary Kleiger, Gill, Gill, Hershko, Hofmann, Kamura, Kleiger, Kolman, Koppenol, Li, Li, Mathias, Nakayama, Ohta, Pan, Petroski, Petroski, Petroski, Pohl, Raymond J. Deshaies, Ruiz, Saha, Schoppink, Schreiber, Schreiber, Schwob, Seol, Silver, Skowyra, Skowyra, Tan, Thrower, Van Loon, Willems, Wu, Xie, Yang, Zheng   +48 more
core   +3 more sources

Hendra virus fusion protein transmembrane domain contributes to pre-fusion protein stability [PDF]

Journal of Biological Chemistry, 2017
Enveloped viruses utilize fusion (F) proteins studding the surface of the virus to facilitate membrane fusion with a target cell membrane. Fusion of the viral envelope with a cellular membrane is required for release of viral genomic material, so the virus can ultimately reproduce and spread.
Stacy R. Webb, Rebecca Ellis Dutch, Tamas L. Nagy, Michael Fried, Hunter N. B. Moseley   +4 more
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Antibody Epitopes of Pneumovirus Fusion Proteins [PDF]

Frontiers in Immunology, 2019
The pneumoviruses respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two widespread human pathogens that can cause severe disease in the young, the elderly, and the immunocompromised. Despite the discovery of RSV over 60 years ago, and hMPV nearly 20 years ago, there are no approved vaccines for either virus.
Jiachen Huang, Jiachen Huang, Darren Diaz, Darren Diaz, Jarrod J. Mousa, Jarrod J. Mousa   +5 more
openaire   +4 more sources

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Epigenetic Editing in Prostate Cancer: Challenges and Opportunities

Epigenetics, 2022
Epigenome editing consists of fusing a predesigned DNA recognition unit to the catalytic domain of a chromatin modifying enzyme leading to the introduction or removal of an epigenetic mark at a specific locus.
Mariana Brütt Pacheco, Vânia Camilo, Rui Henrique, Carmen Jerónimo   +3 more
doaj   +1 more source

Protein–protein interactions in intracellular membrane fusion

Current Opinion in Structural Biology, 2000
The fusion of intracellular vesicles with their target membranes is an essential feature of the compartmental structure of eukaryotic cells. This process requires proteins that dictate the targeting of a vesicle to the correct cellular location, mediate bilayer fusion and, in some systems, regulate the precise time at which fusion occurs.
Andrew P. May, William I. Weis, Kira M. S. Misura   +2 more
openaire   +3 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Multimodal Protein Constructs for Herbivore Insect Control

Toxins, 2012
Transgenic plants expressing combinations of microbial or plant pesticidal proteins represent a promising tool for the efficient, durable control of herbivorous insects.
Frank Sainsbury, Meriem Benchabane, Marie-Claire Goulet, Dominique Michaud   +3 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source