Results 41 to 50 of about 675,878 (209)

Differential cargo mobilisation within Weibel-Palade bodies after transient fusion with the plasma membrane. [PDF]

, 2014
Inflammatory chemokines can be selectively released from Weibel-Palade bodies (WPBs) during kiss-and-run exocytosis. Such selectivity may arise from molecular size filtering by the fusion pore, however differential intra-WPB cargo re-mobilisation ...
Knipe, Laura, Tom Carter (196826), Carter, T, Laura Knipe (196817), Hannah, MJ, Kiskin, Nikolai I, Kiskin, NI, Nikolai I Kiskin, Matthew J. Hannah (196824), Matthew J Hannah, Babich, Victor, Nikolai I. Kiskin (631240), Victor Babich, Knipe, L, Tom Carter, Victor Babich (631241), Laura Knipe, Carter, Tom, Babich, V, Hannah, Matthew J   +19 more
core   +1 more source

Expression of Recombinant Antigens in Escherichia coli: Application on Immunochemical Studies of Schistosoma mansoni Tegumental Antigens

Memorias do Instituto Oswaldo Cruz, 1997
Sm15 and Sm13 are recognized by antibodies from mice protectively vaccinated with tegumental membranes, suggesting a potential role in protective immunity.
Frederico GC Abath, Edeneide M Xavier, Joanne D'Arc B Silva, Marcos A Morais Junior, Silvia ML Montenegro   +4 more
doaj   +1 more source

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment

, 2009
Background: t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Malcolm A S Moore, Martin Ruthardt, Ruthardt, Martin, Oancea, Claudia, Claudia Oancea, Malcolm A. S. Moore, Reinhard Henschler, Henschler, Reinhard, Moore, Malcolm A. S., Zheng, Xiaomin   +10 more
core   +1 more source

ARF-GAP-mediated interaction between the ER-Golgi v-SNAREs and the COPI coat [PDF]

, 2002
In eukaryotic cells, secretion is achieved by vesicular transport. Fusion of such vesicles with the correct target compartment relies on SNARE proteins on both vesicle (v-SNARE) and the target membranes (t-SNARE).
Rein, U., Rein, Ulrike, Anne Spang, Spang, Anne, Hans Dieter Schmitt, Andag, Uwe, Ulrike Rein, Duden, R., Schmitt, Hans Dieter, Duden, Rainer, Spang, A., Andag, U., Uwe Andag, Schmitt, H. D., Rainer Duden, Schmitt, H.   +15 more
core   +1 more source

Inhibition of Akt activity and calcium channel function coordinately drive cell-cell fusion in the BeWO choriocarcinoma placental cell line [PDF]

, 2012
To establish a simple and quantitative live cell fusion assay for placental syncytialization, we generated stable GFP and dsRed expressing fusogenic BeWo cell lines.
Bastie, Claire C., Jeffrey E Pessin, Dimitris Grammatopoulos, Lydia Tesfa (33289), Bastie Claire C., Dimitris Grammatopoulos (187265), Claire C. Bastie (187271), Grammatopoulos Dimitris, Yamada, Eijiro, Grammatopoulos, Dimitris, Eijiro Yamada, Tesfa, Lydia, Eijiro Yamada (187269), Lydia Tesfa, Tesfa Lydia, Claire C Bastie, Vatish Manu, Manu Vatish (187260), Yamada Eijiro, Vatish, Manu, Manu Vatish, Pessin Jeffrey E., Pessin, Jeffrey E., Jeffrey E. Pessin (187274)   +23 more
core   +1 more source

Molecular engineering approaches to half-life extension of therapeutic biomolecules

Frontiers in Pharmacology
Therapeutic biomolecules are widely used to treat various diseases, but their clinical efficacy is often limited by short in vivo half-lives due to rapid renal filtration, proteolytic degradation, and immune clearance.
Yuli Wang, Junliang Chang, Jinghui Liu
doaj   +1 more source

BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility [PDF]

, 2006
Background The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9.
Martin Ruthardt, Beissert Tim, Ruthardt, Martin, Ruthardt Martin, Puccetti, Elena, Zheng Xiaomin, Elena Puccetti, Tim Beissert, Zheng, Xiaomin, Xiaomin Zheng, Beissert, Tim, Güller, Saskia, Güller Saskia, Saskia Güller, Puccetti Elena   +14 more
core   +1 more source

Controlled delivery of membrane proteins to artificial lipid bilayers by nystatin-ergosterol modulated vesicle fusion

, 2006
The study of ion channels and other membrane proteins and their potential use as biosensors and drug screening targets require their reconstitution in an artificial membrane.
Fisher, K.H., Berry, RM, Fisher, K H, Berry, R M, de Planque, MR, de Planque, M R R, Sandison, ME, Watts, A, Mendes, G P, Morgan, Hywel, Watts, A., Berry, Richard, Sandison, M E, de Planque, M.R.R., Sandison, Mairi E., Mendes, GP, Zagnoni, M, Zagnoni, Michele, Watts, Anthony, Berry, R.M., Morgan, H, Mendes, G.P., Fisher, KH   +22 more
core   +1 more source

The FUSION protein crystallization screen

Journal of Applied Crystallography, 2022
The success and speed of atomic structure determination of biological macromolecules by X-ray crystallography depends critically on the availability of diffraction-quality crystals. However, the process of screening crystallization conditions often consumes large amounts of sample and time.
Gorrec, Fabrice, Bellini, Dom
openaire   +3 more sources

Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein

, 2010
Background: The apoptosis-inducing serine protease granzyme B (GrB) is an important factor contributing to lysis of target cells by cytotoxic lymphocytes.
Wels, Winfried, Pranav Oberoi, Jabulowsky, Robert Alexander, Benhar, Itai, Benjamin Dälken, Oberoi, Pranav, Robert A Jabulowsky, Itai Benhar, Winfried S Wels, Dälken, Benjamin   +9 more
core   +1 more source