Results 51 to 60 of about 675,878 (209)

Functional analysis of the Bunyamwera orthobunyavirus Gc glycoprotein [PDF]

, 2009
The virion glycoproteins Gn and Gc of Bunyamwera orthobunyavirus (BUNV, family Bunyaviridae) are encoded by the M RNA genome segment and have roles in both viral attachment and membrane fusion.
Elliott, Richard Michael, Goli, J., Shi, X., Clark, Gordon, Clark, G., Brauburger, Kristina, Brauburger, K., Shi, Xiaohong, Goli, Josthna, Elliott, R.M.   +9 more
core   +1 more source

Antibacterial Fusion Proteins Enhance Moraxella catarrhalis Killing

Frontiers in Immunology, 2020
Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease ...
Maisem Laabei, Maisem Laabei, Lucie Colineau, Serena Bettoni, Karolina Maziarz, David Ermert, Kristian Riesbeck, Sanjay Ram, Anna M. Blom   +8 more
doaj   +1 more source

The ability to enhance the solubility of its fusion partners is an intrinsic property of maltose-binding protein but their folding is either spontaneous or chaperone-mediated. [PDF]

PLoS ONE, 2012
Escherichia coli maltose binding protein (MBP) is commonly used to promote the solubility of its fusion partners. To investigate the mechanism of solubility enhancement by MBP, we compared the properties of MBP fusion proteins refolded in vitro with ...
Sreejith Raran-Kurussi, David S Waugh
doaj   +1 more source

The structure of Herpesvirus Fusion Glycoprotein B-Bilayer Complex reveals the protein-membrane and lateral protein-protein interaction

, 2013
Glycoprotein B (gB) is a key component of the complex herpesvirus fusion machinery. We studied membrane interaction of two gB ectodomain forms and present an electron cryotomography structure of the gB-bilayer complex.
Topf, Maya, Huiskonen, JT, Topf, M., Maurer, U., Whitbeck, J., Maurer, U.E., Gruenewald, Kay, Cohen, G., Cairns, T.M., Eisenberg, R.J., Huiskonen, Juha T., Whitbeck, J.C., Zeev-Ben-Mordehai, T, Cohen, Gary H., Cohen, GH, Cairns, Tina M., Hannah, BP, Hannah, B.P., Cohen, G.H., Pandurangan, A., Zeev-Ben-Mordehai, T., Grünewald, K, Eisenberg, Roselyn J., Cairns, T., Huiskonen, J.T., Maurer, Ulrike E., Grünewald, Kay, Eisenberg, RJ, Topf, M, Grünewald, K., Maurer, UE, Pandurangan, Arun Prasad, Whitbeck, JC, Zeev-Ben-Mordehai, Tzviya, Huiskonen, J., Hannah, Brian P., Hannah, B., Pandurangan, Arun, Pandurangan, AP, Eisenberg, R., Whitbeck, J. Charles, Cairns, TM   +41 more
core   +1 more source

Protein-Protein Fusion Catalyzed by Sortase A

PLoS ONE, 2011
Chimeric proteins boast widespread use in areas ranging from cell biology to drug delivery. Post-translational protein fusion using the bacterial transpeptidase sortase A provides an attractive alternative when traditional gene fusion fails. We describe use of this enzyme for in vitro protein ligation and report the successful fusion of 10 pairs of ...
David A Levary, Ranganath Parthasarathy, Eric T Boder, Margaret E Ackerman   +3 more
openaire   +4 more sources

An overview of the biological disease modifying drugs available for arthritic conditions in South Africa

South African Family Practice, 2016
The past decade has seen a major change in the treatment options and strategies for rheumatoid arthritis (RA) and the other immune-mediated arthritic diseases. The disease modifying antirheumatic drugs (DMARDs) are now used in early stages of the disease
Leonie Harmse, Helmuth Reuter
doaj   +1 more source

Preliminary Analysis of Vital Proteins of the Human Respiratory Syncytial Virus [PDF]

, 2010
Human Respiratory Syncytial Virus infects the vast majority of children under the age of two and reoccurs in adulthood. It is a serious global problem as severe infection and death can result in the very young or very old and in immunocompromised people.
BACHE, HELEN,CLARE
core  

Identification of a Potential Entry-Fusion Complex Based on Sequence Homology of African Swine Fever and Vaccinia Virus

Viruses
African swine fever virus (ASFV) belongs to the family of Asfarviridae, part of the group of nucleocytoplasmic large DNA viruses (NCLDV). Little is known about the internalization of ASFV in the host cell and the fusion membrane events that take place at
Jesús Urquiza, Miguel Ángel Cuesta-Geijo, Isabel García-Dorival, Óscar Fernández, Ana del Puerto, José Fernando Díaz, Covadonga Alonso   +6 more
doaj   +1 more source

Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]

, 2014
Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core   +1 more source

SETD2 in MLL-rearranged leukemia – a complex case

Molecular & Cellular Oncology, 2018
Oncogenic MLL-fusion proteins often hijack essential molecular mechanisms during leukemogenesis. The histone methyltransferase SETD2 was implicated in the regulation of transcription, DNA damage and other cellular processes.
Anna Skucha, Jessica Ebner, Florian Grebien   +2 more
doaj   +1 more source