Results 31 to 40 of about 675,878 (209)

Fusion-protein-assisted protein crystallization [PDF]

Acta Crystallographica Section F Structural Biology Communications, 2015
Fusion proteins can be used directly in protein crystallization to assist crystallization in at least two different ways. In one approach, the `heterologous fusion-protein approach', the fusion partner can provide additional surface area to promote crystal contact formation.
Kobe, Bostjan, Ve, Thomas, Williams, Simon J   +2 more
openaire   +4 more sources

Pseudotyping Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV): F Proteins from Group II NPVs are functionally analogous to AcMNPV GP64 [PDF]

, 2002
GP64, the major envelope glycoprotein of budded virions of the baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV), is involved in viral attachment, mediates membrane fusion during virus entry, and is required for efficient ...
Marcel Westenberg, Lung, O., Gary W. Blissard, Westenberg, M., Just M. Vlak, Douwe Zuidema, Vlak, J.M., Zuidema, D., Blissard, G.W., Oliver Lung   +9 more
core   +1 more source

Role of Sequence and Structure of the Hendra Fusion Protein Fusion Peptide in Membrane Fusion [PDF]

Journal of Biological Chemistry, 2012
Viral fusion proteins are intriguing molecular machines that undergo drastic conformational changes to facilitate virus-cell membrane fusion. During fusion a hydrophobic region of the protein, termed the fusion peptide (FP), is inserted into the target host cell membrane, with subsequent conformational changes culminating in membrane merger.
Everett Clinton, Smith, Sonia M, Gregory, Lukas K, Tamm, Trevor P, Creamer, Rebecca Ellis, Dutch   +4 more
openaire   +2 more sources

Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats

mAbs, 2023
Bispecific antibodies (bsAbs) enable dual binding of different antigens with potential synergistic targeting effects and innovative therapeutic possibilities.
Andreas V. Madsen, Peter Kristensen, Alexander K. Buell, Steffen Goletz   +3 more
doaj   +1 more source

Ataxin-1 fusion partners alter polyQ lethality and aggregation [PDF]

, 2007
Intranuclear inclusion bodies (IBs) are the histopathologic markers of multiple protein folding diseases. IB formation has been extensively studied using fluorescent fusion products of pathogenic polyglutamine (polyQ) expressing proteins.
Rich, T., Varadaraj, A., Archana Varadaraj, Varadaraj Archana, Tina Rich, Rich Tina   +5 more
core   +1 more source

Molecular characterization of an MLL1 fusion and its role in chromosomal instability

Molecular Oncology, 2019
Chromosomal rearrangements involving the mixed‐lineage leukemia (MLL1) gene are common in a unique group of acute leukemias, with more than 100 fusion partners in this malignancy alone. However, do these fusions occur or have a role in solid tumors?
Sreejit Parameswaran, Frederick S. Vizeacoumar, Kalpana Kalyanasundaram Bhanumathy, Fujun Qin, Md. Fahmid Islam, Behzad M. Toosi, Chelsea E. Cunningham, Darrell D. Mousseau, Maruti C. Uppalapati, Peter C. Stirling, Yuliang Wu, Keith Bonham, Andrew Freywald, Hui Li, Franco J. Vizeacoumar   +14 more
doaj   +1 more source

Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines [PDF]

, 2011
The hemagglutinins (HAs) of human H1 and H3 influenza viruses and avian H5 influenza virus were produced as recombinant fusion proteins with the human immunoglobulin Fc domain.
Temperton, Nigel J., Ian M. Jones, Christopher R. Bailey, Eleonora Molesti, Ren, Junyuan, Jones, Ian M., Temperton, Nigel J, Silvia Loureiro, Pongsathon Phapugrangkul, Junyuan Ren, Wendy S. Barclay, Camilo A. Colaco, Molesti, Eleonora, Barclay, Wendy S., Shelton, Holly, Colaco, Camilo A, Phapugrangkul, Pongsathon, Nigel J. Temperton, Loureiro, Silvia, Barclay, Wendy S, Bailey, Christopher R, Holly Shelton, Jones, Ian, Colaco, Camilo A., Bailey, Christopher R.   +24 more
core   +1 more source

Selected Biological Medicinal Products and Their Veterinary Use

Animals, 2020
Definitions of biological medicinal products (BMPs) vary depending on the source. BMPs are manufactured using complex biological/biotechnological processes involving living cell lines, tissues and organisms such as microorganisms, plants, humans and even
Aleksandra Zygmuntowicz, Artur Burmańczuk, Włodzimierz Markiewicz   +2 more
doaj   +1 more source

Improvement of downstream processing of recombinant proteins by means of genetic engineering

, 1993
Flaschel E, Friehs K. Improvement of downstream processing of recombinant proteins by means of genetic engineering. Biotechnology Advances. 1993;11(1):31-77.The rapid advancement of genetic engineering has allowed to produce an impressive number of ...
Flaschel, Erwin, Friehs, Karl
core   +1 more source

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610), Beez, Sabine, Philipp Demmer, Elena Puccetti (66633), Philipp Demmer (123611), Puccetti, Elena, Elena Puccetti, Sabine Beez, Demmer, Philipp   +8 more
core   +1 more source