Results 31 to 40 of about 978,977 (295)

Epigenetic Editing in Prostate Cancer: Challenges and Opportunities

Epigenetics, 2022
Epigenome editing consists of fusing a predesigned DNA recognition unit to the catalytic domain of a chromatin modifying enzyme leading to the introduction or removal of an epigenetic mark at a specific locus.
Mariana Brütt Pacheco, Vânia Camilo, Rui Henrique, Carmen Jerónimo   +3 more
doaj   +1 more source

Innovative surface bio-functionalization by fungal hydrophobins and their engineered variants

Frontiers in Molecular Biosciences, 2022
Research on innovative surface functionalization strategies to develop materials with high added value is particularly challenging since this process is a crucial step in a wide range of fields (i.e., biomedical, biosensing, and food packaging).
Ilaria Stanzione, Rossana Pitocchi, Anna Pennacchio, Paola Cicatiello, Alessandra Piscitelli, Paola Giardina   +5 more
doaj   +1 more source

High-salinity growth conditions promote tat-independent secretion of tat substrates in Bacillus subtilis [PDF]

, 2012
The Gram-positive bacterium Bacillus subtilis contains two Tat translocases, which can facilitate transport of folded proteins across the plasma membrane. Previous research has shown that Tat-dependent protein secretion in B.
Alami, Antelmann, Antelmann, Barnett, Barnett, Berks, Bogsch, Bolhuis, Bongers, Bron, Bursy, Carmine G. Monteferrante, Chaddock, Cline, Colin Robinson, Cristobal, DeLisa, Driessen, Eijlander, Gasson, Harwood, Hoper, James P. Barnett, Jan Maarten van Dijl, Jongbloed, Jongbloed, Jongbloed, Jongbloed, Kolkman, Kouwen, Kouwen, Kunst, Lewis, Maillard, Meile, Meissner, Mendel, Muller, Natale, Nicolas, Palmer, Palmer, Panahandeh, Pommier, René van der Ploeg, Ridder, Robinson, Robinson, Sambrook, Sargent, Sjouke Piersma, Stanley, Thijs R. H. M. Kouwen, Tjalsma, Tjalsma, Tullman-Ercek, van der Ploeg, van Dijl, van Roosmalen, Yuan   +59 more
core   +1 more source

Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4

Pharmaceutics, 2021
CXCR4 is a cytokine receptor used by HIV during cell attachment and infection. Overexpressed in the cancer stem cells of more than 20 human neoplasias, CXCR4 is a convenient antitumoral drug target.
Naroa Serna, José Vicente Carratalá, Oscar Conchillo-Solé, Carlos Martínez-Torró, Ugutz Unzueta, Ramón Mangues, Neus Ferrer-Miralles, Xavier Daura, Esther Vázquez, Antonio Villaverde   +9 more
doaj   +1 more source

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate [PDF]

, 2016
Background Lrrk2, a gene linked to Parkinson\u2019s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes.
Arrigoni, Giorgio, Belluzzi, Elisa, Beltramini, Mariano, Bubacco, Luigi, Carrion, Maria Per\ue8z, Cirnaru, Maria Daniela, Civiero, Laura, Cogo, Susanna, Franchin, Cinzia, Gonnelli, Adriano, Greggio, Elisa, Marte, Antonella, Onofri, Franco, Piccoli, Giovanni, Plotegher, Nicoletta, Russo, Isabella   +15 more
core   +5 more sources

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion [PDF]

, 2006
Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact ...
Chan, David C., Griffin, Erik E.
core   +3 more sources

Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer [PDF]

, 2016
Gene fusions are common cancer-causing mutations, but the molecular principles by which fusion protein products affect interaction networks and cause disease are not well understood.
Babu, M. Madan, Buljan, Marija, Flock, Tilman, Gough, Julian, Latysheva, Natasha S., Maddox, Louis, Oates, Matt E., Weatheritt, Robert J.   +7 more
core   +3 more sources

Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats

mAbs, 2023
Bispecific antibodies (bsAbs) enable dual binding of different antigens with potential synergistic targeting effects and innovative therapeutic possibilities.
Andreas V. Madsen, Peter Kristensen, Alexander K. Buell, Steffen Goletz   +3 more
doaj   +1 more source

Molecular characterization of an MLL1 fusion and its role in chromosomal instability

Molecular Oncology, 2019
Chromosomal rearrangements involving the mixed‐lineage leukemia (MLL1) gene are common in a unique group of acute leukemias, with more than 100 fusion partners in this malignancy alone. However, do these fusions occur or have a role in solid tumors?
Sreejit Parameswaran, Frederick S. Vizeacoumar, Kalpana Kalyanasundaram Bhanumathy, Fujun Qin, Md. Fahmid Islam, Behzad M. Toosi, Chelsea E. Cunningham, Darrell D. Mousseau, Maruti C. Uppalapati, Peter C. Stirling, Yuliang Wu, Keith Bonham, Andrew Freywald, Hui Li, Franco J. Vizeacoumar   +14 more
doaj   +1 more source

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens. [PDF]

, 2016
BACKGROUND: Plants deploy immune receptors to detect pathogen-derived molecules and initiate defense responses. Intracellular plant immune receptors called nucleotide-binding leucine-rich repeat (NLR) proteins contain a central nucleotide-binding (NB ...
Cevik, Volkan, Dagdas, Gulay, Jones, Jonathan, Krasileva, Ksenia, Sarris, Panagiotis   +4 more
core   +11 more sources