Results 11 to 20 of about 675,878 (209)
Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects
Pharmaceutics, 2023 Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity.
Vladislav S. Rybchenko +4 more
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Long acting growth hormone (LAGH), an update
Frontiers in Pediatrics, 2023 In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available
Margaret Steiner Grillo +2 more
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eLife, 2021 Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 fusion proteins are chimeric transcription factors and initiating oncogenic ...
Nicole Merritt +11 more
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Viruses, 2023 African swine fever virus (ASFV) encodes more than 150 proteins, most of them of unknown function. We used a high-throughput proteomic analysis to elucidate the interactome of four ASFV proteins, which potentially mediate a critical step of the infection
Isabel García-Dorival +6 more
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Toxins, 2020 The deadly pandemic named COVID-19, caused by a new coronavirus (SARS-CoV-2), emerged in 2019 and is still spreading globally at a dangerous pace. As of today, there are no proven vaccines, therapies, or even strategies to fight off this virus.
Yasser Hassan, Sherry Ogg, Hui Ge
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Molecules, 2023 Oncogenic fusion proteins, arising from chromosomal rearrangements, have emerged as prominent drivers of tumorigenesis and crucial therapeutic targets in cancer research.
Yichao Kong +5 more
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Capsid-Targeted Viral Inactivation: A Novel Tactic for Inhibiting Replication in Viral Infections
Viruses, 2016 Capsid-targeted viral inactivation (CTVI), a conceptually powerful new antiviral strategy, is attracting increasing attention from researchers. Specifically, this strategy is based on fusion between the capsid protein of a virus and a crucial effector ...
Xingcui Zhang +5 more
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RECOMBINANT HORSERADISH PEROXIDASE FOR ANALYTICAL APPLICATIONS [PDF]
Biotechnologia Acta, 2012 The article deals with prospects of using recombinant horseradish peroxidase in analytical biochemistry and biotechnology. Problems of recombinant horseradish peroxidase cloning in different expression systems, possible approaches to their solution ...
А.M. Egorov +3 more
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Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses
Frontiers in Chemistry, 2021 Membrane fusion events allow enveloped viruses to enter and infect cells. The study of these processes has led to the identification of a number of proteins that mediate this process. These proteins are classified according to their structure, which vary
Camille Lozada +5 more
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C-terminal eYFP fusion impairs Escherichia coli MinE function [PDF]
Open Biology, 2020 The Escherichia coli Min system plays an important role in the proper placement of the septum ring at mid-cell during cell division. MinE forms a pole-to-pole spatial oscillator with the membrane-bound ATPase MinD, resulting in MinD concentration being ...
Navaneethan Palanisamy +3 more
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