Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteins [PDF]
, 2012 Fluorescent fusion proteins are widely used to study protein localization and interaction dynamics in living cells. However, to fully characterize proteins and to understand their function it is crucial to determine biochemical characteristics such as ...
Sandra B. Hake (165089) +15 more
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Structure and function of bacterial dynamin-like proteins [PDF]
, 2012 Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
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Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c In Vitro [PDF]
, 2008 Background: Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin.
Nia J Bryant +17 more
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A virus-encoded cell-cell fusion machine dependent on surrogate adhesins. [PDF]
PLoS Pathogens, 2008 The reovirus fusion-associated small transmembrane (FAST) proteins function as virus-encoded cellular fusogens, mediating efficient cell-cell rather than virus-cell membrane fusion. With ectodomains of only approximately 20-40 residues, it is unclear how
Jayme Salsman +3 more
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Molecular Engineering of Therapeutic Cytokines
Antibodies, 2013 Over the past three decades, a large body of work has been directed at the development of therapeutic cytokines. Despite their central role in immune modulation, only a handful of cytokine therapeutics has achieved regulatory approval.
Daniel Christ +2 more
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Epigenetic Editing in Prostate Cancer: Challenges and Opportunities
Epigenetics, 2022 Epigenome editing consists of fusing a predesigned DNA recognition unit to the catalytic domain of a chromatin modifying enzyme leading to the introduction or removal of an epigenetic mark at a specific locus.
Mariana Brütt Pacheco +3 more
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Innovative surface bio-functionalization by fungal hydrophobins and their engineered variants
Frontiers in Molecular Biosciences, 2022 Research on innovative surface functionalization strategies to develop materials with high added value is particularly challenging since this process is a crucial step in a wide range of fields (i.e., biomedical, biosensing, and food packaging).
Ilaria Stanzione +5 more
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Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4
Pharmaceutics, 2021 CXCR4 is a cytokine receptor used by HIV during cell attachment and infection. Overexpressed in the cancer stem cells of more than 20 human neoplasias, CXCR4 is a convenient antitumoral drug target.
Naroa Serna +9 more
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Fusion of secretory vesicles isolated from rat liver [PDF]
, 1978 Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
Dahl, Gerhard +2 more
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Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]
, 2012 Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Weiping Lu (120665) +32 more
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