Results 81 to 90 of about 21,307 (236)

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, EarlyView.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Infective Endocarditis Caused by Fusobacterium nucleatum and Slackia exigua Secondary to Poor Oral Health

Annals of Internal Medicine: Clinical Cases
Infective endocarditis caused by anaerobes may be underrecognized. Here, we report a case of polymicrobial anaerobic infective endocarditis secondary to poor oral health.
Taro Sawabe, Shunsuke Kosugi, Takashi Matono   +2 more
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Distinct Microbiota and Functional Pathway Profiles Define Success and Failure in Regenerative Endodontic Treatment

International Endodontic Journal, EarlyView.
ABSTRACT Aim To characterize the intracanal microbiota and identify key microbial taxa and functional pathways associated with regenerative endodontic treatment (RET) outcomes. Methodology In this observational cohort study, 196 samples were collected at five time points from external tooth surfaces (T1, T4) and root canals (T2, T3, T5).
Leimarembi Devi Naorem, Alina Wikström, Peter Quach, Lokeshwaran Manoharan, Ronald Ordinola‐Zapata, Olena Rakhimova, Malin Brundin, Nelly Romani Vestman   +7 more
wiley   +1 more source

Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To characterise multi‐kingdom salivary microbiome profiles across clinically defined periodontal states and identify stage‐specific taxonomic and functional alterations using shotgun metagenomic sequencing. Materials and Methods In this cross‐sectional study, 204 adults (mean age 40.3 ± 7.6 years) from the SECRETO study (NCT01934725 ...
Muhammed Manzoor, Jaakko Leskelä, Eija Könönen, Leo Lahti, Jukka Putaala, Pirkko J. Pussinen, Susanna Paju   +6 more
wiley   +1 more source

Alteration of subgingival microbiome in patients with type 2 diabetes induced by diabetes treatment

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Diabetes and periodontal disease, a bacterial infection involving the oral microbiome, have a bidirectional relationship. However, the relationship between poor glycemic control and the oral microbiome remains unclear. The aim of this study was to assess the direct effect of intensive glycemic control on the oral microbiome ...
Moe Inoue, Akito Sakanaka, Naoto Katakami, Hitoshi Nishizawa, Kazuo Omori, Naohiro Taya, Asuka Ishikawa, Shota Mayumi, Hiroki Takeuchi, Atsuo Amano, Toru Takeshita, Eiichiro Fukusaki, Iichiro Shimomura, Masae Kuboniwa   +13 more
wiley   +1 more source

Differences in the Gastric Microbiotas of Neighboring Populations With Divergent Risks of Gastric Cancer

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Although Helicobacter pylori plays a central role in gastric cancer (GC), other microorganisms involved in gastric dysbiosis may also impact carcinogenesis. We aimed to characterize gastric dysbiosis and its role in the transition from non‐atrophic gastritis (NAG) to gastric premalignant lesions (GPLs) in two populations from Nariño,
Juan Camilo Caguazango, Karla Vinasco, Isidora Simovic, Yomaira Yépez Caicedo, Marino Coral Bedoya, Nadeem O. Kaakoush, Natalia Castaño‐Rodríguez   +6 more
wiley   +1 more source

Oral and Pancreatobiliary Microbiota in Cancer: A Systematic Review of Compositional Alterations and Their Clinical Implications

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Associations between microbial dysbiosis and malignancies of the pancreatobiliary system have been described in recent studies. As a result of the limited number of studies that have been done specifically on the malignancies of the biliary tract, information regarding oral, biliary and tumour‐related microbial alterations was ...
Esperouz Fariba, Villani Rosanna, Ciavarella Domenico, Serviddio Gaetano, Lorusso Mauro, Lo Russo Lucio   +5 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source