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Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
Cancers, 2019 Colorectal patients generally have the maximum counts of Fusobacterium nucleatum (F. nucleatum) in tumors and elevate colorectal adenomas and carcinomas, which show the lowest rate of human survival. Hence, F.
Kumar Ganesan, Ge Zhang, Baojun Xu
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Fusobacterium nucleatum – Friend or foe?
Journal of Inorganic Biochemistry, 2021Fusobacterium nucleatum (F. nucleatum) is one of the most abundant Gram-negative anaerobic bacteria, part of the gut, and oral commensal flora, generally found in human dental plaque. Its presence could be associated with various human diseases, including, e.g., periodontal, angina, lung and gynecological abscesses.
Kamila, Stokowa-Sołtys +2 more
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European Journal of Cancer Prevention, 2015
The human intestinal microbiota is a plethora of diverse microbial species, wherein certain bacteria considered as driver bacteria with procarcinogenic features contribute directly toward colonic epithelium cell damage to initiate colorectal carcinogenesis.
Arif, Bashir +4 more
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The human intestinal microbiota is a plethora of diverse microbial species, wherein certain bacteria considered as driver bacteria with procarcinogenic features contribute directly toward colonic epithelium cell damage to initiate colorectal carcinogenesis.
Arif, Bashir +4 more
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Genetic Transformation of Fusobacterium nucleatum
2020Fusobacterium nucleatum is a human periodontal pathogen that causes opportunistic infections. It has been implicated in preterm birth and has as a pathogen of colorectal cancer. However, it is a common member of the oral microbiota and can have a symbiotic relationship with its hosts. To date, studies of F.
Akihiro, Yoshida, Akihiko, Ikegami
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Biosynthesis of meso-lanthionine in Fusobacterium nucleatum
Archives of Biochemistry and Biophysics, 2023The opportunistic oral pathogen, Fusobacterium nucleatum contains meso-lanthionine as the diaminodicarboxylic acid in the pentapeptide crosslink of the peptidoglycan layer. The diastereomer, l,l-lanthionine is formed by lanthionine synthase, a PLP-dependent enzyme that catalyzes the β-replacement of l-cysteine with a second equivalent of l-cysteine. In
Amanda, Darbyshire +2 more
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Amino acid fermentation by Fusobacterium nucleatum
Archives of Oral Biology, 1968Abstract Fusobacterium nucleatum (Fusobacterium fusiforme) is a weakly saccharolytic gram negative anaerobic rod which is indigenous to the oral cavity of man. This organism fermented aspartate, cysteine, glutamate, glutamine, histidine, lysine, methionine, serine and threonine forming butyrate and acetate as the main acid end products.
W J, Loesche, R J, Gibbons
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JAAPA, 2016
ABSTRACT This article describes an uncommon presentation of a subdural empyema in a young man. Because the patient's initial presentation consisted of nonspecific abdominal complaints, subdural empyema was not initially considered. However, a thorough medical history, including recent travel history, and appropriate multidisciplinary ...
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ABSTRACT This article describes an uncommon presentation of a subdural empyema in a young man. Because the patient's initial presentation consisted of nonspecific abdominal complaints, subdural empyema was not initially considered. However, a thorough medical history, including recent travel history, and appropriate multidisciplinary ...
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Fusobacterium nucleatum and colorectal cancer: A mechanistic overview
Journal of Cellular Physiology, 2019 Colorectal cancer (CRC) is the third most prevalent cancer in the world. There are many risk factors involved in CRC. According to recent findings, the tumor microenvironment and feces samples of patients with CRC are enriched by Fusobacterium nucleatum.
Nasser Hashemi Goradel +2 more
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Neutrophil chemiluminescence in response to Fusobacterium nucleatum
Journal of Periodontal Research, 1982During the interaction of bacteria or other particles with neutrophils, oxygen consumption is increased, and unstable reduction products are produced. Chemiluminescence is the light energy produced in the neutrophil by the generation of unstable oxygen radicals. These oxygen radicals are thought to be important in the destruction of bacteria as well as
S A, Passo, S A, Syed, J, Silva
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Desulfuration of Cysteine and Methionine by Fusobacterium nucleatum
Journal of Dental Research, 1986Fusobacterium nucleatum is a Gram-negative anaerobic rod-shaped bacterium frequently isolated from human dental plaque. It is capable of the desulfuration of cysteine and methionine, resulting in the formation of sulfide and thiol volatiles, respectively. Intact cells, as well as cell-free extracts produced by French pressure cell lysis of F. nucleatum,
R, Pianotti, S, Lachette, S, Dills
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