Results 41 to 50 of about 33,412 (306)

Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma.

Genome Research, 2012
An estimated 15% or more of the cancer burden worldwide is attributable to known infectious agents. We screened colorectal carcinoma and matched normal tissue specimens using RNA-seq followed by host sequence subtraction and found marked over ...
M. Castellarin, René L. Warren, J. Freeman, L. Dreolini, M. Krzywinski, Jaclyn Strauss, Rebecca Barnes, P. Watson, E. Allen-Vercoe, Richard A. Moore, R. Holt   +10 more
semanticscholar   +1 more source

Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles.

Cell Host and Microbe, 2023
Rheumatoid arthritis (RA) is an autoimmune disorder that has been associated with the gut microbiota. However, whether and how the gut microbiota plays a pathogenic role in RA remains unexplored. Here, we observed that Fusobacterium nucleatum is enriched
Mukeng Hong, Zhuang Li, Haihua Liu, Songyuan Zheng, Fangling Zhang, Junqing Zhu, Hao Shi, Haixin Ye, Z. Chou, Lei Gao, Jianxin Diao, Yang Zhang, Dongxin Zhang, Shixian Chen, Hongwei Zhou, Juan Li   +15 more
semanticscholar   +1 more source

Unveiling the etiology of peritonsillar abscess using next generation sequencing

Annals of Clinical Microbiology and Antimicrobials, 2023
Background Peritonsillar abscess (PTA) is a severe deep neck space infection with an insufficiently characterized bacterial etiology. We aimed to reveal the bacteria associated with PTA applying next generation sequencing (NGS).
Merili Saar, Risto Vaikjärv, Ülle Parm, Priit Kasenõmm, Siiri Kõljalg, Epp Sepp, Madis Jaagura, Andres Salumets, Jelena Štšepetova, Reet Mändar   +9 more
doaj   +1 more source

The Role of Fusobacterium nucleatum in Oral and Colorectal Carcinogenesis

Microorganisms, 2023
In recent years, several studies have suggested a strong association of microorganisms with several human cancers. Two periodontopathogenic species in particular have been mentioned frequently: Fusobacterium nucleatum (F.
P. Pignatelli, Federica Nuccio, Adriano Piattelli, M. C. Curia   +3 more
semanticscholar   +1 more source

Endothelial Cell Response to Fusobacterium nucleatum [PDF]

Infection and Immunity, 2016
ABSTRACTVascular response is an essential aspect of an effective immune response to periodontal disease pathogens, as new blood vessel formation contributes to wound healing and inflammation. Gaining a greater understanding of the factors that affect vascular response may then contribute to future breakthroughs in dental medicine.
Reila Tainá, Mendes, Daniel, Nguyen, Danielle, Stephens, Ferda, Pamuk, Daniel, Fernandes, Thomas E, Van Dyke, Alpdogan, Kantarci   +6 more
openaire   +2 more sources

Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression

Journal of experimental & clinical cancer research : CR, 2023
Background Fusobacterium nucleatum ( Fn ) acts as a procarcinogenic bacterium in colorectal carcinoma (CRC) by regulating the inflammatory tumor microenvironment (TME).
Xuehua Kong, Yu Zhang, Linwei Xiang, Yan You, Yaqian Duan, Yuqing Zhao, Shue Li, Rui Wu, Jiangbo Zhang, Lan Zhou, Liang Duan   +10 more
semanticscholar   +1 more source

Unraveling the Role of Fusobacterium nucleatum in Colorectal Cancer: Molecular Mechanisms and Pathogenic Insights

Cancers
Simple Summary Fusobacterium nucleatum, a gram-negative anaerobic bacterium, plays a pivotal role in colorectal cancer (CRC) pathogenesis. It induces chronic inflammation via cytokines such as IL-1β, IL-6, and TNF-α, fostering tumor progression.
L. Galasso, Fabrizio Termite, I. Mignini, Giorgio Esposto, R. Borriello, Federica Vitale, A. Nicoletti, M. Paratore, M. Ainora, Antonio Gasbarrini, M. Zocco   +10 more
semanticscholar   +1 more source

Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway

Gut microbes, 2023
Senescence frequently occurs in cancer cells in response to chemotherapy (called therapy-induced senescence). Senescent cells can exert paracrine effects through the senescence-associated secretory phenotype (SASP) promoting cancer recurrence and ...
Jian-Wei Zhang, Dangling Zhang, Haisen Yin, Han Zhang, Kunqiao Hong, Jing‐ping Yuan, Baoping Yu   +6 more
semanticscholar   +1 more source

Modulation of the Host Cell Transcriptome and Epigenome by Fusobacterium nucleatum

mBio, 2021
Fusobacterium nucleatumF ...
Cody A. Despins, Scott D. Brown, Avery V. Robinson, Andrew J. Mungall, Emma Allen-Vercoe, Robert A. Holt   +5 more
doaj   +1 more source

Intratumoral Fusobacterium nucleatum Recruits Tumor-Associated Neutrophils to Promote Gastric Cancer Progression and Immune Evasion

Cancer Research
Intratumoral F. nucleatum activates NF-κB signaling to facilitate gastric cancer immune evasion by promoting tumor-associated neutrophil recruitment that sensitizes tumors to immune checkpoint blockade therapy.
Tianhao Zhang, Ying Li, E. Zhai, Risheng Zhao, Yan Qian, Zhixin Huang, Yinan Liu, Zeyu Zhao, Xiang Xu, Jianqiu Liu, Zikang Li, Zhi Liang, Ran Wei, Linying Ye, Jinping Ma, Qing-ping Wu, Jianhui Chen, Shirong Cai   +17 more
semanticscholar   +1 more source