Results 71 to 80 of about 33,412 (306)

Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation

Gut microbes, 2023
The anaerobic bacterium Fusobacterium nucleatum is significantly associated with human colorectal cancer (CRC) and is considered a significant contributor to the disease.
C. Martin-Gallausiaux, Laurène Salesse, Diego García-Weber, L. Marinelli, Fabienne Béguet-Crespel, V. Brochard, Camille Le Gléau, Alexandre Jamet, J. Doré, H. Blottière, Cécile Arrieumerlou, N. Lapaque   +11 more
semanticscholar   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Fusobacterium lineage profiling facilitates the clarification of the associations between non-nucleatum Fusobacterium and colorectal cancer

npj Biofilms and Microbiomes
Non-nucleatum Fusobacterium may play a nonnegligible role in colorectal cancer (CRC) and certain Fusobacterium lineages (namely, L1 and L5) have shown specific associations with CRC. We aim to clarify the complex connections between Fusobacterium and CRC.
Yuli Wu, Guo Ji, Dongyan Han, Youhua Zhang, Xingchen Zhu, Hao Li, Man Li, Yaohui Gao, Ruting Xie, Min Xu, Ling Lu, Zixin Deng, Qing Wei, Huanlong Qin, Dexi Bi   +14 more
doaj   +1 more source

Research on the Mechanism of Mannose Oligosaccharide Enhancing the Inhibitory Effect of Bifidobacterium breve on the Growth of Fusobacterium nucleatum

Shipin gongye ke-ji
To explore the synergistic inhibitory effect and mechanism of Bifidobacterium and oligosaccharides on Fusobacterium nucleatum, six common Bifidobacterium species (Bifidobacterium animalis, Bifidobacterium longum, Bifidobacterium infantis, Bifidobacterium
Xuyan ZHANG, Ruijie LIU, Bo ZHAO, Xiaoxi XU   +3 more
doaj   +1 more source

Peptidoglycan precursor from Fusobacterium nucleatum contains lanthionine [PDF]

Journal of Bacteriology, 1991
Fusobacterium nucleatum was grown in the presence of [14C]UDP. By means of sequential precipitation and chromatographic separation of the cytoplasmic content, a peptidoglycan [14C]UDP pentapeptide containing lanthionine was isolated. This finding indicates that lanthionine is synthesized and incorporated as such during the assembly of the peptidoglycan.
A, Fredriksen, E N, Vasstrand, H B, Jensen   +2 more
openaire   +2 more sources

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Fusobacterium Genomics Using MinION and Illumina Sequencing Enables Genome Completion and Correction

mSphere, 2018
Understanding the virulence mechanisms of human pathogens from the genus Fusobacterium has been hindered by a lack of properly assembled and annotated genomes.
S. Michelle Todd, Robert E. Settlage, Kevin K. Lahmers, Daniel J. Slade   +3 more
doaj   +1 more source

Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15

Nature Communications
Fusobacterium nucleatum (F. nucleatum) promotes intestinal tumor growth and its relative abundance varies greatly among patients with CRC, suggesting the presence of unknown, individual-specific effectors in F. nucleatum-dependent carcinogenesis.
Huiyuan Zhu, Man Li, Dexi Bi, Huiqiong Yang, Yaohui Gao, Feifei Song, Jiayi Zheng, Ruting Xie, Youhua Zhang, Hu Liu, Xuebing Yan, Cheng Kong, Yefei Zhu, Qian Xu, Q. Wei, Huanlong Qin   +15 more
semanticscholar   +1 more source

Periodontopathogens Porphyromonas gingivalis and Fusobacterium nucleatum and Their Roles in the Progression of Respiratory Diseases

Pathogens, 2023
The intricate interplay between oral microbiota and the human host extends beyond the confines of the oral cavity, profoundly impacting the general health status.
Tao Shi, Jiale Wang, Jiajia Dong, Pingyue Hu, Qiang Guo   +4 more
semanticscholar   +1 more source

Fusobacterium nucleatum: a commensal-turned pathogen [PDF]

Current Opinion in Microbiology, 2015
Fusobacterium nucleatum is an anaerobic oral commensal and a periodontal pathogen associated with a wide spectrum of human diseases. This article reviews its implication in adverse pregnancy outcomes (chorioamnionitis, preterm birth, stillbirth, neonatal sepsis, preeclampsia), GI disorders (colorectal cancer, inflammatory bowel disease, appendicitis ...
openaire   +2 more sources