Results 91 to 100 of about 5,149 (183)

Transcriptomic analysis from 3D cultures of Presilinin‐1 G206A carriers reveals genetic expression differences associated with age‐of‐onset variability [PDF]

Alzheimers Dement
Abstract Background The Presenilin‐1 (PSEN1) G206A mutation has been identified in Puerto Ricans (PRs) with Alzheimer disease (AD), as a founder effect in the African ancestral background. The G206A mutation exhibits large age‐of‐onset (AOO) variation (range 30‐90 years) between carriers.
Celis K, Griswold A, Rajabli F, Ramirez A, Nam Y, Adams L, Whitehead P, Mena P, Sanchez J, Golightly C, DeRosa B, Silva‐Vergara C, Acosta H, McInerney K, Dykxhoorn D, Feliciano‐Astacio B, Cuccaro M, Vance J, Pericak‐Vance M, Young J.   +19 more
europepmc   +2 more sources

Prognostically Significant Glycan Profiles of Clear Cell Renal Cell Carcinoma Identified by Integrated Glycome–Methylome Analysis

Pathology International, Volume 76, Issue 1, January 2026.
Comprehensive glycomics analysis and genome‐wide DNA methylation analysis using tissue samples of clear cell renal cell carcinoma (ccRCC) have revealed that the glycan profile, including “immature” N‐type glycans, may be attributable to epigenetic regulation of glycogenes.
Yoshiko Kitazume, Eri Arai, Mao Fujimoto, Kentaro Ohara, Atsushi Matsuda, Shuichi Kakuda, Hiroyuki Fujimoto, Akiko Miyagi Maeshima, Nobuyoshi Hiraoka, Teruhiko Yoshida, Atsushi Kuno, Yae Kanai   +11 more
wiley   +1 more source

Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma [PDF]

, 2017
Cutaneous squamous cell carcinomas (cSCC) are among the most common and highly mutated human malignancies. Solar UV radiation is the major factor in the etiology of cSCC. Wholeexome sequencing of 18 microdissected tumor samples (cases) derived from SKH-1
Aikseng Ooi, Alan Evans, Albena T. Dinkova-Kostova, Brandon Praslicka, Catherine A. Harwood, Charlotte M. Proby, Elena V. Knatko, Harwood, Jennings, Karin J. Purdie, Kim, Knatko, Leiter, Levine, Maureen Higgins, Sutherland, Varghese   +16 more
core   +2 more sources

Chinese Herbal Medicines for Diabetic Cardio‐Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Currently, the global incidence of diabetes is increasing, particularly in populous developing regions. In China, over 290 million people are affected by diabetic cardio‐cerebrovascular diseases. These diseases account for more than 40% of deaths and impose a significant economic burden on both society and families.
Ying Su, Shuwen Luo, Wei Li, Cuicui Cheng, Wei Liu, Xinyu Yang, Zhen Xing, Eric Gumpricht   +7 more
wiley   +1 more source

Predicted mouse peroxisome-targeted proteins and their actual subcellular locations. [PDF]

, 2011
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Herberth, Marlis, Kurochkin, Igor V, Mizuno, Yumi, Okazaki, Yasushi, Schönbach, Christian   +4 more
core  

Diffuse large B-cell lymphoma: sub-classification by massive parallel quantitative RT-PCR. [PDF]

, 2014
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity with remarkably variable clinical outcome. Gene expression profiling (GEP) classifies DLBCL into activated B-cell like (ABC), germinal center B-cell like (GCB), and Type-III subtypes, with ...
Du, Ming-Qing, Gao, Zifen, Xue, Xuemin, Zeng, Naiyan   +3 more
core   +1 more source

Fucosyltransferase 8‐Derived Circular RNA Drives M2 Polarization of Macrophages Through ENO1‐TNF Signaling Axis to Promote Lung Cancer Progression

Thoracic Cancer, Volume 16, Issue 23, December 2025.
The novel mechanism by which circFUT8 promotes lung cancer progression is that circFUT8 binds to ENO1, enhancing glycolytic metabolism to the upregulation of JUN, CSF2, CSF1, TRAF1, CCL5, MMP9, which in turn drive the polarization of tumor‐associated macrophages toward an immunosuppressive M2 phenotype, fostering a pro‐tumor microenvironment.
Yang Ren, Yidan Shen, Qingguo Wu, Peng Zhang, Lei Wang, Feng Li, Yinzhong Shen   +6 more
wiley   +1 more source

Genome-wide determination of drug localization [PDF]

, 2014
A vast number of small-molecule ligands, including therapeutic drugs under development and in clinical use, elicit their effects by binding specific proteins associated with the genome.
Anders, Lars, Bradner, James E., Fan, Zi Peng, Guenther, Matthew G., Lee, Tong Ihn, Lovén, Jakob, Marineau, Jason J., Qi, Jun, Rahl, Peter B., Sigova, Alla A., Smith, William B., Young, Richard A.   +11 more
core   +1 more source

Design and Evaluation of Eb4Mab‐7‐mG2a: A Dual‐Action Anti‐EphB4 Monoclonal Antibody for Targeted Breast Cancer Therapy

Cancer Science, Volume 116, Issue 12, Page 3417-3430, December 2025.
Eb4Mab‐7‐mG2a, an anti‐EphB4 monoclonal antibody, significantly suppressed tumor growth in the MCF‐7 xenograft model. Tumor volume and weight were markedly reduced in treated mice, demonstrating its antitumor efficacy against EphB4‐positive breast cancer.
Tomokazu Ohishi, Hiroyuki Suzuki, Mika K. Kaneko, Tomohiro Tanaka, Akiko Harakawa, Junjiro Yoshida, Daisuke Tatsuda, Yukinari Kato, Manabu Kawada   +8 more
wiley   +1 more source

FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins

Stem Cell Reports, 2018
Summary: Since hundreds of clinical trials are investigating the use of multipotent stromal cells (MSCs) for therapeutic purposes, effective delivery of the cells to target tissues is critical.
Baarkullah Awan, David Turkov, Cameron Schumacher, Antonio Jacobo, Amber McEnerney, Ashley Ramsey, Gege Xu, Dayoung Park, Stefanos Kalomoiris, Wei Yao, Li-En Jao, Miguel L. Allende, Carlito B. Lebrilla, Fernando A. Fierro   +13 more
doaj   +1 more source