Results 101 to 110 of about 5,149 (183)

Effect of Gabapentin Administered With Prednisolone, Ciclosporin or a Placebo on Clinical Outcomes and Motor Activity in Cats With Atopic Skin Syndrome: A Prospective, Blinded, Placebo‐Controlled Study

Veterinary Dermatology, Volume 36, Issue 6, Page 814-824, December 2025.
Background: Gabapentin reportedly decreases central sensitisation, a disorder associated with chronic pruritus in humans, although this is not well documented in cats. Its combined use with the standard antipruritic therapy for feline atopic skin syndrome (FASS) is not yet described.
Jeanne Morency, Éric Troncy, Aliénor Delsart, Colombe Otis, Jérôme R. E. Del Castillo, Andrea Gonzales, Jason Ross, Maxim Moreau, Jean‐Pierre Pelletier, Johanne Martel‐Pelletier, Frédéric Sauvé   +10 more
wiley   +1 more source

Glycosylated notch and cancer [PDF]

, 2016
Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development.
Couto, Africa, Georgiou, Marios, Nagarajan, Usha, Pakkiriswami, Shanmugasundaram   +3 more
core   +1 more source

Efficacy and Field Safety of Ilunocitinib for the Control of Allergic Dermatitis in Client‐Owned Dogs: A Multicenter, Double‐Masked, Randomised, Placebo‐Controlled Clinical Trial

Veterinary Dermatology, Volume 36, Issue 6, Page 825-837, December 2025.
Background: Inhibition of the Janus kinase pathway is an established treatment for allergic dermatitis. Objective: To evaluate the efficacy and safety of ilunocitinib for control of pruritus in dogs with allergic dermatitis in a randomised, double‐masked clinical trial.
Sophie Forster, Candace M. Trout, Simona Despa, Annette Boegel, Darren Berger, Stephen King   +5 more
wiley   +1 more source

The CS sulphation motifs 4C3, 7D4, 3B3[-]; and perlecan identify stem cell populations and niches, activated progenitor cells and transitional tissue development in the fetal human elbow [PDF]

, 2016
We compared the immunohistochemical distribution of (i) the novel chondroitin sulphate (CS) sulphation motifs 7D4, 4C3 and 3B3[-], (ii) native heparan sulphate (HS) and Δ-HS ‘stubs’ generated by heparitinase III digestion and (iii) the HS-proteoglycan ...
Caterson, Bruce, Hayes, Anthony Joseph, Hughes, Clare Elizabeth, Little, Christopher B., Melrose, James, Smith, Susan M.   +5 more
core   +1 more source

A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis

Cancer Cell, 2017
Association of aberrant glycosylation with melanoma progression is based mainly on analyses of cell lines. Here we present a systems-based study of glycomic changes and corresponding enzymes associated with melanoma metastasis in patient samples.
Praveen, Agrawal, Barbara, Fontanals-Cirera, Elena, Sokolova, Samson, Jacob, Christopher A, Vaiana, Diana, Argibay, Veronica, Davalos, Meagan, McDermott, Shruti, Nayak, Farbod, Darvishian, Mireia, Castillo, Beatrix, Ueberheide, Iman, Osman, David, Fenyö, Lara K, Mahal, Eva, Hernando   +15 more
openaire   +2 more sources

Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova [PDF]

, 2006
Glycans are the most abundant and most diverse biopolymers in nature. Because of their highly specific interactions with physiological receptors, they participate in many crucial biological processes.
GORDAN LAUC, JERKA DUMIC, MIRNA FLÖGEL, OLGA GORNIK   +3 more
core   +1 more source

cFUT8 promotes liver cancer progression by miR-548c/FUT8 axis [PDF]

Signal Transduction and Targeted Therapy, 2021
Chong Li, Zhuoyuan Xin, Luyun He, Jing Ning, Kaisu Lin, Jiahui Pan, Jagannatha Rao, Guoqing Wang, Hong Zhu   +8 more
openaire   +3 more sources

Core fucosylation regulates the ovarian response via FSH receptor during follicular development

Journal of Advanced Research
Introduction: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.
Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li   +9 more
doaj   +1 more source

Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis

eLife
This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration.
Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki   +6 more
doaj   +1 more source

Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating α1, 6-Fucosylation via Wnt/β-Catenin Signaling Pathway

Frontiers in Physiology, 2017
Cancer pain is a common and severe complication of human breast cancer, and relieving pain is fundamental strategy in the treatment. Fentanyl, as an opioid analgesic, is widely used in breast cancer patients. However, little is known about its effects on
Hong-Fang Yang, Ming Yu, Hui-Dan Jin, Jia-Qi Yao, Zhi-Li Lu, Iddrisu B. Yabasin, Qiu Yan, Qing-Ping Wen   +7 more
doaj   +1 more source