Results 141 to 150 of about 5,464,381 (308)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Professional Development for Teachers in the Digital Age: A Comparative Analysis of Online Training Programs and Policy Implementation

open access: yesBehavioral Sciences
In the digital age, online teacher professional development (TPD) has become a key strategy for enhancing instructional quality and ensuring equitable access to continuous learning.
Yuanhai Gu   +3 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Self build design and construction processes and the future of sustainable design education [PDF]

open access: yes, 2012
The paper was given during the First Annual International Conference on Construction, 20-23 June2011,in Athens, Greece; it was submitted and peer reviewed after the conference again and selected to be included in a book as a chapter.Research groups ...
Tracada, Eleni
core   +1 more source

THE FUTURE IS EDUCATION FOR CITIZENSHIP

open access: yesInternational Journal of Human Sciences Research
Society is currently immersed in a daily change where technology, the media and global challenges are demanding agents of a change in citizenship. Education is the tool for the transformation of future citizenship and democratic governments are aware of this. In Spain, Education for Citizenship began to gain importance since the enactment of the LOE in
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Not all screens are equal: associations between screen-based sedentary behavior and physical activity in Chinese children and adolescents

open access: yesFrontiers in Public Health
BackgroundPrior research has produced mixed results on the association between screen-based sedentary behavior (SSB) and physical activity (PA) in children and adolescents. Limited attention has been paid to how different types of SSB relate to PA across
Yuan Wang   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Library purchasing consortia: achieving value for money and shaping the emerging electronic marketplace [PDF]

open access: yes, 1998
Drawing on a current study, funded by the British Library Research and Innovation Centre, the context of higher education libraries is discussed, including funding and costs and recent major official reports on education and libraries.
Ball, David, Pye, Jo
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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