Results 101 to 110 of about 631,839 (239)

Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands

BMC Bioinformatics, 2018
Background The Open Targets Platform integrates different data sources in order to facilitate identification of potential therapeutic drug targets to treat human diseases.
Johannes M Freudenberg, Ian Dunham, Philippe Sanseau, Deepak K Rajpal   +3 more
doaj   +1 more source

Neomycin induces high‐affinity agonist binding of G‐protein‐coupled receptors [PDF]

, 1989
Eva Herrmann, Peter Gierschik, Karl H. Jakobs   +2 more
openalex   +1 more source

Computational Modeling for the Activation Cycle of G-proteins by G-protein-coupled Receptors

, 2010
In this paper, we survey five different computational modeling methods. For comparison, we use the activation cycle of G-proteins that regulate cellular signaling events downstream of G-protein-coupled receptors (GPCRs) as a driving example.
Adriana Compagnoni, Alida Palmisano, Andrew D. Howard, Andrew Phillips, Andrew Phillips, Brian K. Kobilka, Corrado Priami, Federica Ciocchetta, Federica Ciocchetta, Gabriel Ciobanu, J'er^ome Feret, Jane Hillston, Janet D. Robishaw, John W. Pinney, Jos'e M. G. Vilar, Joseph Glavy, Joël Bockaert, Kristen L. Pierce, Louis M. Luttrell, Luca Cardelli, Luca Cardelli, Luca Cardelli, Luca Cardelli, Luca Cardelli, Maciej Koutny, Maria Luisa Guerriero, Mor Peleg, Nan Hao, Ozan Kahramanogullari, Tau M. Yi, Tommy White, William M. Oldham, Yifei Bao, Yifei Bao   +33 more
core   +2 more sources

Large-scale polymorphism discovery in macaque G-protein coupled receptors [PDF]

, 2013
Background: G-protein coupled receptors (GPCRs) play an inordinately large role in human health. Variation in the genes that encode these receptors is associated with numerous disorders across the entire spectrum of disease.
Goswami, Dharmendra B, Miller, Gregory M, Ogawa, Lisa M, Vallender, Eric J, Ward, Joshua M   +4 more
core   +2 more sources

secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila [PDF]

, 2019
Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products.
Dent, J., Drapeau, P., Feingold, D., Knogler, L., Nilson, L., O'Donnell, M., Starc, T.   +6 more
core   +2 more sources

G protein-coupled receptors: Role in metabolic disorders

Frontiers in Endocrinology, 2022
Luiz F. Barella, Shanu Jain, Sai P. Pydi
doaj   +1 more source

Sequence homology between bacteriorhodopsin and G‐protein coupled receptors: exon shuffling or evolution by duplication? [PDF]

, 1993
Ethan Will Taylor, Atul Agarwal
openalex   +1 more source

Co-expression of Gbeta 5 Enhances the Function of Two Ggamma Subunit-like Domain-containing Regulators of G Protein Signaling Proteins [PDF]

, 2000
Regulators of G protein signaling (RGS) stimulate the GTPase activity of G protein Galpha subunits and probably play additional roles. Some RGS proteins contain a Ggamma subunit-like (GGL) domain, which mediates a specific interaction with Gbeta 5. The
Chen, Ching-Kang, He, Wei, Kovoor, Abraham, Lester, Henry A., Simon, Melvin I., Wensel, Theodore G.   +5 more
core  

GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. [PDF]

, 1993
Stephen M. Strittmatter, Stephen C. Cannon, Elliott M. Ross, Tsutomu Higashijima, Mark C. Fishman   +4 more
openalex   +1 more source

Identification of a G protein coupled receptor induced in activated T cells. [PDF]

, 1993
Mark H. Kaplan, Jeremy C. Smith, Roy S. Sundick   +2 more
openalex   +1 more source