Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure [PDF]
, 2016 Dimeric/oligomeric states of G-protein coupled receptors have been difficult to target. We report here bivalent ligands consisting of two identical oxytocin-mimetics that induce a three order magnitude boost in G-protein signaling of oxytocin receptors ...
Bice Chini +15 more
core +5 more sources
Mini G protein probes for active G protein– coupled receptors (GPCRs) in live cells [PDF]
, 2018 G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor receptor activation and downstream signaling ...
Carpenter, Byron +6 more
core +2 more sources
Neomycin induces high‐affinity agonist binding of G‐protein‐coupled receptors [PDF]
, 1989 Eva Herrmann +2 more
openalex +1 more source
Regulation of G protein-coupled receptors by palmitoylation and cholesterol
BMC Biology, 2012 Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols.
Goddard Alan D, Watts Anthony
doaj +1 more source
Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor [PDF]
, 2012 G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are ...
Abrol, Ravinder +5 more
core +1 more source
Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors. [PDF]
, 1994 Jean‐Philippe Pin +3 more
openalex +1 more source
Sequence homology between bacteriorhodopsin and G‐protein coupled receptors: exon shuffling or evolution by duplication? [PDF]
, 1993 Ethan Will Taylor, Atul Agarwal
openalex +1 more source
The Interaction of Phospholipase C-{beta}3 with Shank2 Regulates mGluR-mediated Calcium Signal [PDF]
, 2005 Phospholipase C-{beta} isozymes that are activated by G protein-coupled receptors (GPCR) and heterotrimeric G proteins carry a PSD-95/Dlg/ZO-1 (PDZ) domain binding motif at their C terminus. Through interactions with PDZ domains, this motif may endow the
Hwang, Jong-Ik +5 more
core
Cloning, sequencing and tissue distribution of a candidate G protein‐coupled receptor from rat pituitary gland [PDF]
, 1991 Karin A. Eidne +5 more
openalex +1 more source
Identification of a G protein coupled receptor induced in activated T cells. [PDF]
, 1993 Mark H. Kaplan +2 more
openalex +1 more source