Results 61 to 70 of about 519,324 (267)

Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors

Diseases, 2020
Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings.
Duaa Althumairy, Xiaoping Zhang, Nicholas Baez, George Barisas, Deborah A. Roess, George R. Bousfield, Debbie C. Crans   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Computational studies of G protein-coupled receptor complexes: Structure and dynamics [PDF]

, 2017
G protein-coupled receptors (GPCRs) are ubiquitously expressed transmembrane proteins associated with a wide range of diseases such as Alzheimer's, Parkinson, schizophrenia, and also implicated in in several abnormal heart conditions.
de Sousa Moreira, Irina, Moreira, Irina S., Sub NMR Spectroscopy, Ozge Sensoy, Javeria Shabbir, Jose G. Almeida, Sensoy, Ozge, Morra, Giulia, NMR Spectroscopy, Irina S. Moreira, Almeida, Jose G, Giulia Morra, Shabbir, Javeria, Almeida, Jose G.   +13 more
core   +1 more source

The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors

Memorias do Instituto Oswaldo Cruz
Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria.
Michelle Ngai, Mary Ann McDowell
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Genetic Polymorphisms of Prokineticins and Prokineticin Receptors Associated with Human Disease

Life
Prokineticins (PKs) are low molecular weight proteins that exert their effects by binding to two seven-transmembrane G-protein-coupled receptors (prokineticin receptors, PKRs).
Roberta Lattanzi, Rossella Miele
doaj   +1 more source

The mutational landscape of human olfactory G protein-coupled receptors

BMC Biology, 2021
Background Olfactory receptors (ORs) constitute a large family of sensory proteins that enable us to recognize a wide range of chemical volatiles in the environment.
Ramón Cierco Jimenez, Nil Casajuana-Martin, Adrián García-Recio, Lidia Alcántara, Leonardo Pardo, Mercedes Campillo, Angel Gonzalez   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation

, 2023
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive.
O’Brien, Shannon L., Stepniewski, Tomasz M, Hill, Stephen J., Maria Makarova, Hoffmann, Carsten, Mistry, Ravi, Shannon L. O’Brien, Davide Calebiro, Stephen J. Hill, Carsten Hoffmann, Julia Drube, Jana Selent, Baidya, Mithu, Calebiro, Davide, Mithu Baidya, Lanoiselée, Yann, Medel-Lacruz, Brian, Owen, Dylan M., Owen, Dylan M, Stepniewski, Tomasz M., Tamara Miljus, Dylan M. Owen, Miljus, Tamara, Goulding, Joëlle, Stepniewski, Tomasz Maciej, 1988-, Grimes, Jak, Hill, Stephen J, Drube, Julia, Jak Grimes, Ravi Mistry, Medel Lacruz, Brian, Koszegi, Zsombor; id_orcid, Zsombor Koszegi, Arun K. Shukla, Koszegi, Zsombor, Makarova, Maria, Yann Lanoiselée, Selent, Jana, Brian Medel-Lacruz, O'Brien, Shannon L., Tomasz M. Stepniewski, O'Brien, Shannon L; id_orcid, Shukla, Arun K., Shukla, Arun K, Joëlle Goulding   +44 more
core   +1 more source

RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling

BMC Genomics, 2006
Background Many marketed therapeutic agents have been developed to modulate the function of G protein-coupled receptors (GPCRs). The regulators of G-protein signaling (RGS proteins) are also being examined as potential drug targets.
Huang Hsien-Da, Wu Li-Cheng, Sun Wei-Hsin, Fang Yu-Ching, Juan Hsueh-Fen, Horng Jorng-Tzong   +5 more
doaj   +1 more source