Results 61 to 70 of about 16,197,158 (192)

Allostery of atypical modulators at oligomeric G protein-coupled receptors

Scientific Reports, 2021
Many G protein-coupled receptors (GPCRs) are therapeutic targets, with most drugs acting at the orthosteric site. Some GPCRs also possess allosteric sites, which have become a focus of drug discovery.
Rabindra V. Shivnaraine, Brendan Kelly, Gwendolynne Elmslie, Xi-Ping Huang, Yue John Dong, Margaret Seidenberg, James W. Wells, John Ellis   +7 more
doaj   +1 more source

The sushi domains and their role in GABA(B) receptor compartmentalization [PDF]

, 2010
GABAB receptors are G protein-coupled receptors ...
Biermann, Barbara
core   +1 more source

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs [PDF]

, 2012
When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are useful alternatives for probing receptor function. In the
Christiansen, Elisabeth, Tikhonova, I.G., Ulven, T., Hudson, B., Tikhonova, Irina G, Adams, D.R., Grundmann, Manuel, Milligan, Graeme, Hudson, Brian D, Christiansen, E., Kostenis, Evi, Kostenis, E., Adams, David R, Milligan, G., Tikhonova, Irina G; id_orcid, Ulven, Trond, Grundmann, M.   +16 more
core   +1 more source

Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors

Diseases, 2020
Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings.
Duaa Althumairy, Xiaoping Zhang, Nicholas Baez, George Barisas, Deborah A. Roess, George R. Bousfield, Debbie C. Crans   +6 more
doaj   +1 more source

The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors

Memorias do Instituto Oswaldo Cruz
Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria.
Michelle Ngai, Mary Ann McDowell
doaj   +1 more source

Cell-free expression and molecular modeling of the γ-secretase complex and G-protein-coupled receptors [PDF]

, 2013
Alzheimer’s disease (AD), which was first reported more than a century ago by Alhzeimer, is one of the commonest forms of dementia which affects >30 million people globally (>8 million in Europe).
Ghoshdastider, Umesh
core  

Fungal G-protein-coupled receptors::mediators of pathogenesis and targets for disease control [PDF]

, 2018
G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence.
Brown, Neil Andrew, Sanne Schrevens, Schrevens, S., Patrick van Dijck, Brown, Neil, Schrevens, Sanne, Goldman, G. H., Van Dijck, P., Gustavo Henrique Goldman, van Dijck, Patrick, Goldman, Gustavo, Brown, N. A., Goldman, Gustavo Henrique, Neil Andrew Brown   +13 more
core   +1 more source

Genetic Polymorphisms of Prokineticins and Prokineticin Receptors Associated with Human Disease

Life
Prokineticins (PKs) are low molecular weight proteins that exert their effects by binding to two seven-transmembrane G-protein-coupled receptors (prokineticin receptors, PKRs).
Roberta Lattanzi, Rossella Miele
doaj   +1 more source

The mutational landscape of human olfactory G protein-coupled receptors

BMC Biology, 2021
Background Olfactory receptors (ORs) constitute a large family of sensory proteins that enable us to recognize a wide range of chemical volatiles in the environment.
Ramón Cierco Jimenez, Nil Casajuana-Martin, Adrián García-Recio, Lidia Alcántara, Leonardo Pardo, Mercedes Campillo, Angel Gonzalez   +6 more
doaj   +1 more source

Hierarchical classification of G-protein-coupled receptors with a PSO/ACO algorithm [PDF]

, 2006
In our previous work we have proposed a hybrid Particle Swarm Optimisation / Ant Colony Optimisation (PSO/ACO) algorithm for discovering classification rules.
Holden, Nicholas, Freitas, Alex A.
core