Results 41 to 50 of about 16,197,158 (192)

The Protein Arginine Methyltransferase PRMT-5 Regulates SER-2 Tyramine Receptor-Mediated Behaviors in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2018
G protein-coupled receptors are 7-pass transmembrane receptors that couple to heterotrimeric G proteins to mediate cellular responses to a diverse array of stimuli.
Alexander Bowitch, Kerry L. Michaels, Michael C. Yu, Denise M. Ferkey   +3 more
doaj   +1 more source

Fever-like temperature modification differentially affects in vitro signaling of bradykinin B-1 and B-2 receptors [PDF]

, 2011
The bradykinin (BK) B-2 and B-1 receptors (B2R, B1R) belong to the rhodopsin-like G protein-coupled receptors (GPCRs) and are involved in (patho)physiological processes such as blood pressure regulation or inflammation.
Dinkel, Klaus, Faussner, Alexander, Marianne Jochum, Jasmin Leschner, Alexander Faussner, Jochum, Marianne, Leschner, Jasmin, Larisa Ring, Ring, Larisa, Jens Feierler, Feierler, Jens, Klaus Dinkel   +11 more
core   +1 more source

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation [PDF]

, 2023
β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive.
O’Brien, Shannon L., Stepniewski, Tomasz M, Hill, Stephen J., Maria Makarova, Hoffmann, Carsten, Mistry, Ravi, Shannon L. O’Brien, Davide Calebiro, Stephen J. Hill, Carsten Hoffmann, Julia Drube, Jana Selent, Baidya, Mithu, Calebiro, Davide, Mithu Baidya, Lanoiselée, Yann, Medel-Lacruz, Brian, Owen, Dylan M., Owen, Dylan M, Stepniewski, Tomasz M., Tamara Miljus, Dylan M. Owen, Miljus, Tamara, Goulding, Joëlle, Stepniewski, Tomasz Maciej, 1988-, Grimes, Jak, Hill, Stephen J, Drube, Julia, Jak Grimes, Ravi Mistry, Medel Lacruz, Brian, Koszegi, Zsombor; id_orcid, Zsombor Koszegi, Arun K. Shukla, Koszegi, Zsombor, Makarova, Maria, Yann Lanoiselée, Selent, Jana, Brian Medel-Lacruz, O'Brien, Shannon L., Tomasz M. Stepniewski, O'Brien, Shannon L; id_orcid, Shukla, Arun K., Shukla, Arun K, Joëlle Goulding   +44 more
core   +1 more source

Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]

, 2009
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core  

An artificial immune system for clustering amino acids in the context of protein function classification [PDF]

, 2009
This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon, Clark, Edward, Flower, Darren R., Secker, Andrew D., Davies, Matthew N., Freitas, Alex A.   +5 more
core   +1 more source

Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching [PDF]

, 2008
Cellular signal transduction is dynamic, with signaling proteins continually associating and dissociating into and from protein complexes. Here we present a fluorescence recovery after photobleaching technique to determine the lifetime of protein ...
Gousseva, Veronika, Laporte, Stéphane A., Swain, Peter S, Swain, Peter S., Simaan, May, Laporte, Stéphane A   +5 more
core   +1 more source

G‐protein‐coupled receptors and melanoma [PDF]

Pigment Cell & Melanoma Research, 2008
SummaryG‐protein‐coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over‐expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and ...
Hwa Jin, Lee, Brian, Wall, Suzie, Chen
openaire   +2 more sources

G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides

Toxins, 2017
Chronic pain is a complex and debilitating condition associated with a large personal and socioeconomic burden. Current pharmacological approaches to treating chronic pain such as opioids, antidepressants and anticonvulsants exhibit limited efficacy in ...
James T. Daniel, Richard J. Clark
doaj   +1 more source

Fusion protein strategies for cryo-EM study of G protein-coupled receptors

Nature Communications, 2022
Here, Zhang et al. explore fusion protein strategies to facilitate cryo-EM structural studies of GPCRs alone- without signal transducers- in ligand bound or unliganded form.
Kaihua Zhang, Hao Wu, Nicholas Hoppe, Aashish Manglik, Yifan Cheng   +4 more
doaj   +1 more source

GPCRTree: online hierarchical classification of GPCR function [PDF]

, 2008
Background: G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR.
Davies Matthew N, Clark, Edward, Halling-Brown Mark, Flower Darren R, Moss, David S., Alex A Freitas, Halling-Brown, Mark D., Clark, E., Timmis Jon, Flower, Darren R, Andrew Secker, Freitas, Alex A., Timmis, J., Davies, M.N., David S Moss, Secker, Andrew D., Secker, A., Halling-Brown, Mark, Moss David S, Timmis, Jon, Freitas, A.A., Mark Halling-Brown, Clark Edward, Secker Andrew, Secker, Andrew, Flower, Darren R., Jon Timmis, Edward Clark, Matthew N Davies, Freitas Alex A, Davies, Matthew N., Darren R Flower, Flower, D.R.   +32 more
core   +1 more source