Results 31 to 40 of about 519,324 (267)

Interaction of Prokineticin Receptors with Accessory Proteins

Encyclopedia, 2023
G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G proteins) but also through their associations with a variety of additional partner ...
Roberta Lattanzi, Rossella Miele
doaj   +1 more source

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A–
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
core   +1 more source

GPCRs in Intracellular Compartments: New Targets for Drug Discovery

Biomolecules, 2022
The architecture of eukaryotic cells is defined by extensive membrane-delimited compartments, which entails separate metabolic processes that would otherwise interfere with each other, leading to functional differences between cells.
Irene Fasciani, Marco Carli, Francesco Petragnano, Francesco Colaianni, Gabriella Aloisi, Roberto Maggio, Marco Scarselli, Mario Rossi   +7 more
doaj   +1 more source

Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?

Cells, 2021
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great ...
Pravita Balijepalli, Ciera C. Sitton, Kathryn E. Meier   +2 more
doaj   +1 more source

The Protein Arginine Methyltransferase PRMT-5 Regulates SER-2 Tyramine Receptor-Mediated Behaviors in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2018
G protein-coupled receptors are 7-pass transmembrane receptors that couple to heterotrimeric G proteins to mediate cellular responses to a diverse array of stimuli.
Alexander Bowitch, Kerry L. Michaels, Michael C. Yu, Denise M. Ferkey   +3 more
doaj   +1 more source

Fever-like temperature modification differentially affects in vitro signaling of bradykinin B-1 and B-2 receptors [PDF]

, 2011
The bradykinin (BK) B-2 and B-1 receptors (B2R, B1R) belong to the rhodopsin-like G protein-coupled receptors (GPCRs) and are involved in (patho)physiological processes such as blood pressure regulation or inflammation.
Dinkel, Klaus, Faussner, Alexander, Marianne Jochum, Jasmin Leschner, Alexander Faussner, Jochum, Marianne, Leschner, Jasmin, Larisa Ring, Ring, Larisa, Jens Feierler, Feierler, Jens, Klaus Dinkel   +11 more
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

GPCRTree: online hierarchical classification of GPCR function [PDF]

, 2008
Background: G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR.
Davies Matthew N, Clark, Edward, Halling-Brown Mark, Flower Darren R, Moss, David S., Alex A Freitas, Halling-Brown, Mark D., Clark, E., Timmis Jon, Flower, Darren R, Andrew Secker, Freitas, Alex A., Timmis, J., Davies, M.N., David S Moss, Secker, Andrew D., Secker, A., Halling-Brown, Mark, Moss David S, Timmis, Jon, Freitas, A.A., Mark Halling-Brown, Clark Edward, Secker Andrew, Secker, Andrew, Flower, Darren R., Jon Timmis, Edward Clark, Matthew N Davies, Freitas Alex A, Davies, Matthew N., Darren R Flower, Flower, D.R.   +32 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Phylogenomic analysis reveals extensive phylogenetic mosaicism in the Human GPCR Superfamily [PDF]

, 2007
A novel high throughput phylogenomic analysis (HTP) was applied to the rhodopsin G-protein coupled receptor (GPCR) family. Instances of phylogenetic mosaicism between receptors were found to be frequent, often as instances of correlated mosaicism and ...
Allaby, Robin G., Woodwark, Mathew, Robin G. Allaby, Mathew Woodwark   +3 more
core   +1 more source