Results 11 to 20 of about 726,031 (356)
G Protein-Coupled Receptors in Osteoarthritis [PDF]
Frontiers in Endocrinology, 2022 Osteoarthritis (OA) is the most common chronic joint disease characterized, for which there are no available therapies being able to modify the progression of OA and prevent long-term disability. Critical roles of G-protein coupled receptors (GPCRs) have
Fanhua Wang +4 more
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G protein-coupled receptors and obesity
Frontiers in Endocrinology, 2023 G protein-coupled receptors (GPCRs) have emerged as important drug targets for various chronic diseases, including obesity and diabetes. Obesity is a complex chronic disease that requires long term management predisposing to type 2 diabetes, heart ...
Alessandro Pocai
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Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain [PDF]
BiomoleculesMas-related G-protein-coupled receptors constitute a distinct family of GPCRs expressed in some subsets of sensory neurons and immune cells. Increasing evidence highlights their contribution to the modulation of nociceptive signaling and neuroimmune ...
Mario García-Domínguez
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G Protein-Coupled Receptors in Taste Physiology and Pharmacology
Frontiers in Pharmacology, 2020 Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in mammals and are responsible for the regulation of most physiological functions.
Raise Ahmad, Julie E. Dalziel
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G Protein-coupled Receptors [PDF]
Journal of Biological Chemistry, 1998 Nearly 2000 G protein-coupled receptors (GPCRs) have been reported since bovine opsin was cloned in 1983 (1) and the b-adrenergic receptor in 1986 (2).
T. Ji, M. Grossmann, I. Ji
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G Protein-Coupled Receptors: A Century of Research and Discovery
Circulation ResearchGPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with ≈800 members.
Sudarshan Rajagopal, Preston Anderson
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Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
Endocrine Reviews, 2000 Ulrik Gether
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Hemorphins Targeting G Protein-Coupled Receptors
Pharmaceuticals, 2021 Hemorphins are short peptides produced by the proteolysis of the beta subunit of hemoglobin. These peptides have diverse physiological effects especially in the nervous and the renin-angiotensin systems.
Mohammed Akli Ayoub, Ranjit Vijayan
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Advances on Mrgprs itch receptors and their ligands
Pifu-xingbing zhenliaoxue zazhi, 2023 Although histamine is an important physiologically active substance in pruritus,antihistamine drugs can only relieve a small proportion of symptoms in chronic pruritus.
Jing HU, Zhijian CAO
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G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? [PDF]
Molecular Pharmacology, 2018 Estimates vary regarding the number of G protein-coupled receptors (GPCRs), the largest family of membrane receptors that are targeted by approved drugs, and the number of such drugs that target GPCRs.
K. Sriram, P. Insel
semanticscholar +3 more sources