Results 21 to 30 of about 16,197,158 (192)

Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases

Cells, 2021
G protein-coupled receptors (GPCRs) have originally been described as a family of receptors activated by hormones, neurotransmitters, and other mediators.
Derek Strassheim, Timothy Sullivan, David C. Irwin, Evgenia Gerasimovskaya, Tim Lahm, Dwight J. Klemm, Edward C. Dempsey, Kurt R. Stenmark, Vijaya Karoor   +8 more
doaj   +1 more source

A Robust and Rapid Method of Producing Soluble, Stable, and Functional G-Protein Coupled Receptors [PDF]

, 2011
Membrane proteins, particularly G-protein coupled receptors (GPCRs), are notoriously difficult to express. Using commercial E.coli cell-free systems with the detergent Brij-35, we could rapidly produce milligram quantities of 13 unique GPCRs ...
Braun, Dieter, Shuguang Zhang, Baaske Philipp, Moran Jerabek-Willemsen, Geissler, Sandra, Duhr, Stefan, Duhr Stefan, Corin, Karolina A., Sandra Geissler, Wienken Christoph J., Christoph J. Wienken, Geissler Sandra, Jerabek-Willemsen, Moran, Christoph J Wienken, Zhang Shuguang, Stefan Duhr, Emily Brown, Wang Xiaoqiang, Philipp Baaske, Deepali B. Ravel, Brown, Emily, Song Junyao, Xiaoqiang Wang, Braun Dieter, Karolina Corin, Junyao Song, Wang, Xiaoqiang, Dieter Braun, Baaske, Philipp, Wienken, Christoph J., Ravel Deepali B., Corin, Karolina, Ravel, Deepali B., Brown Emily, Song, Junyao, Jerabek-Willemsen Moran, Corin Karolina, Zhang, Shuguang, Deepali B Ravel, Brown, Emily E., Ra Geissler   +40 more
core   +1 more source

Powdered G-Protein-Coupled Receptors [PDF]

The Journal of Physical Chemistry Letters, 2016
Preparation and storage of functional membrane proteins such as G-protein-coupled receptors (GPCRs) are crucial to the processes of drug delivery and discovery. Here, we describe a method of preparing powdered GPCRs using rhodopsin as the prototype. We purified rhodopsin in CHAPS detergent with low detergent to protein ratio so the bulk of the sample ...
Suchithranga M D C, Perera, Udeep, Chawla, Michael F, Brown   +2 more
openaire   +2 more sources

Role of G-protein coupled receptors in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an ...
Yuanqiang Li, Boyu Li, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +4 more
doaj   +1 more source

Regulating G protein-coupled receptors by topological inversion

eLife, 2019
G protein-coupled receptors (GPCRs) are a family of proteins containing seven transmembrane helices, with the N- and C-terminus of the protein located at the extracellular space and cytosol, respectively.
Bray Denard, Sungwon Han, JungYeon Kim, Elliott M Ross, Jin Ye   +4 more
doaj   +1 more source

GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bas Vroling, Pin, J.-P., Palczewski, K., Camacho-Artacho, Marta, Pin, J.P., Lucy Skrabanek, Jean-Philippe Pin, Marta Camacho-Artacho, Devi, Lakshmi A, Graeme Milligan, Marta Filizola, Campagne, Fabien, Fabien Campagne, Martin J. Lohse, Jufang Shan, Lohse, Martin J, Vriend, Gerrit, Khelashvili, George, Milligan, Graeme, Camacho-Artacho, M., Skrabanek, L., George Khelashvili, Campagne, F., Susan R. George, Lakshmi A. Devi, Filizola, M., Pin, Jean-Philippe, Vroling, B., Bouvier, M., Devi, L.A., Richard R. Neubig, Marc Parmentier, George, Susan R, Palczewski, Krzysztof, Dorff, K., Shan, J., Vriend, G., Michel Bouvier, Lohse, M.J., Bouvier, Michel, Skrabanek, Lucy, Vroling, Bas, Filizola, Marta, Neubig, Richard R, Gerrit Vriend, Dorff, Kevin, Parmentier, Marc, Khelashvili, G., Javitch, J.A., Shan, Jufang, Parmentier, M., Javitch, Jonathan A, Krzysztof Palczewski, Kevin Dorff, Jonathan A. Javitch, George, S.R., Neubig, R.R., Milligan, G.   +57 more
core   +3 more sources

Peptide ligand recognition by G protein-coupled receptors

Frontiers in Pharmacology, 2015
The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
doaj   +1 more source

Regulators of G protein signalling proteins in the human myometrium [PDF]

, 2009
The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Ladds, Graham, Thornton, Steven, Zervou, Sevasti I., Vatish, Manu, Davey, John   +4 more
core   +1 more source

G-Protein coupled receptors: answers from simulations

Beilstein Journal of Organic Chemistry, 2017
Molecular-dynamics (MD) simulations are playing an increasingly important role in research into the modes of action of G-protein coupled receptors (GPCRs).
Timothy Clark
doaj   +1 more source

Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?

Frontiers in Cellular Neuroscience, 2016
Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research.
Kari A Johnson, David M Lovinger
doaj   +1 more source