G-protein coupled receptor structure
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 Because of their central role in regulation of cellular function, structure/function relationships for G-protein coupled receptors (GPCR) are of vital importance, yet only recently have sufficient data been obtained to begin mapping those relationships. GPCRs regulate a wide range of cellular processes, including the senses of taste, smell, and vision,
Yeagle, Philip L., Albert, Arlene D.
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Phylogenomic analysis reveals extensive phylogenetic mosaicism in the Human GPCR Superfamily [PDF]
, 2007 A novel high throughput phylogenomic analysis (HTP) was applied to the rhodopsin G-protein coupled receptor (GPCR) family. Instances of phylogenetic mosaicism between receptors were found to be frequent, often as instances of correlated mosaicism and ...
Allaby, Robin G. +3 more
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G Protein-Coupled Receptors in Cancer [PDF]
International Journal of Molecular Sciences, 2016 Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is underappreciated. Numerous lines of evidence now associate GPCRs and their downstream signaling targets in cancer growth and development.
Bar-Shavit, Rachel +6 more
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Stabilization of G protein-coupled receptors by point mutations
Frontiers in Pharmacology, 2015 G protein-coupled receptors (GPCRs) are flexible integral membrane proteins involved in transmembrane signaling. Their involvement in many physiological processes makes them interesting targets for drug development.
Franziska eHeydenreich +7 more
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Agonist and antagonist TRUPATH assays for G protein-coupled receptors
STAR Protocols, 2022 Summary: TRUPATH is a bioluminescence resonance energy transfer-based platform for quantifying G protein-coupled receptor activity via dissociation of heterotrimeric G protein biosensors.
Jeffrey F. DiBerto +3 more
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G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton [PDF]
, 2005 G protein-coupled receptor kinase 2 (GRK2) phosphorylates and desensitizes activated G protein-coupled receptors (GPCRs). Here, we identify ezrin as a novel non-GPCR substrate of GRK2. GRK2 phosphorylates glutathione S-transferase (GST)-ezrin, but not an
Pitcher, JA, Cant, SH
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G-protein-coupled receptor kinases
Kidney International, 1996 beta-Adrenergic receptors are prototypes of the many G-protein-coupled receptors. Activation and inactivation of these receptors are regulated by multiple mechanisms which can affect either their function or their expression. The most obvious changes of such receptor systems are induced by activation of the receptors themselves by their respective ...
Lohse, Martin J. +3 more
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An experimental comparison of classification algorithms for hierarchical prediction of protein function [PDF]
, 2007 Some data can be naturally organised as a hierarchy of classes. The classification of data in such a hierarchy poses some unique challenges to data miners. One particular case of this is the classification of GPCR proteins by their function.
Matthew N. Davies +11 more
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Enhancing the fight against malaria : from genome to structure and activity of a G-protein coupled receptor from the mosquito, Anopheles Gambiae [PDF]
, 2010 Includes abstract.Includes bibliographical references (leaves 183-184).G-proton coupled receptors (GPCRs) are excellent drug targets that occupy a central position in the physiology of insects and are involved in transmission of signal from the ...
Mugumbate, Grace Chitima
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Methods for Studying Endocytotic Pathways of Herpesvirus Encoded G Protein-Coupled Receptors
Molecules, 2020 Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeostasis,
Maša Mavri +5 more
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