Results 191 to 200 of about 3,592,863 (264)

G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles. [PDF]

BMC Immunol
Paniskaki K, Stervbo U, Goretzki S, Hufnagel D, Anft M, Heidecke H, Westhoff TH, Rohn H, Felderhoff-Mueser U, Witzke O, Dohna-Schwake C, Babel N.   +11 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Human and viral chemokines differentially modulate G protein signaling, β-arrestin recruitment and chemotaxis mediated by the viral G protein-coupled receptor ORF74. [PDF]

Cell Commun Signal
Kong Q, Van Bosstraeten B, Jacquemyn M, Daelemans D, De Jonghe S, Schols D, Van Loy T.   +6 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors. [PDF]

Nat Commun
Pohl F, Seufert F, Chung YK, Schick R, Kieslich B, Schöneberg T, Langenhan T, Hildebrand PW, Sträter N.   +8 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Targeting the G-protein-coupled estrogen receptor: a novel therapeutic strategy in cutaneous T-cell lymphoma. [PDF]

Blood Neoplasia
Özistanbullu D, Bahrami K, Doll M, Reichenbach G, Pöschl MS, Wilhelm R, Zöller N, König A, Spahn P, Jäger M, Quist SR, Scheller T, Winkler L, Nicolay JP, Schilling B, Kaufmann R, Meissner M, Kleemann J, Kippenberger S.   +18 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dietary anthocyanidin pelargonidin activates G protein-coupled receptor 35. [PDF]

FEBS J
Nakashima F, Shimomura S, Wakabayashi M, Loh WQ, Ando H, Sei H, Hattori H, Utomo DH, Kita M, Inoue A, Uchida K, Shibata T.   +11 more
europepmc   +1 more source

Dissecting G-protein signaling pathways in the fruit pathogen Penicillium expansum: implications for pathogenesis and patulin production. [PDF]

Mol Hortic
Chen Y, Xu D, Xing M, Chen T, Li B, Tian S.   +5 more
europepmc   +1 more source