Results 191 to 200 of about 3,599,561 (264)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Human and viral chemokines differentially modulate G protein signaling, β-arrestin recruitment and chemotaxis mediated by the viral G protein-coupled receptor ORF74. [PDF]

Cell Commun Signal
Kong Q, Van Bosstraeten B, Jacquemyn M, Daelemans D, De Jonghe S, Schols D, Van Loy T.   +6 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Dietary anthocyanidin pelargonidin activates G protein-coupled receptor 35. [PDF]

FEBS J
Nakashima F, Shimomura S, Wakabayashi M, Loh WQ, Ando H, Sei H, Hattori H, Utomo DH, Kita M, Inoue A, Uchida K, Shibata T.   +11 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Targeting the G-protein-coupled estrogen receptor: a novel therapeutic strategy in cutaneous T-cell lymphoma. [PDF]

Blood Neoplasia
Özistanbullu D, Bahrami K, Doll M, Reichenbach G, Pöschl MS, Wilhelm R, Zöller N, König A, Spahn P, Jäger M, Quist SR, Scheller T, Winkler L, Nicolay JP, Schilling B, Kaufmann R, Meissner M, Kleemann J, Kippenberger S.   +18 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors. [PDF]

Nat Commun
Pohl F, Seufert F, Chung YK, Schick R, Kieslich B, Schöneberg T, Langenhan T, Hildebrand PW, Sträter N.   +8 more
europepmc   +1 more source

Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders. [PDF]

J Psychiatr Brain Sci
Lee BH, Meyer CM, Speca DJ, Díaz E.
europepmc   +1 more source

Dissecting G-protein signaling pathways in the fruit pathogen Penicillium expansum: implications for pathogenesis and patulin production. [PDF]

Mol Hortic
Chen Y, Xu D, Xing M, Chen T, Li B, Tian S.   +5 more
europepmc   +1 more source