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Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation. [PDF]

open access: yesJ Am Chem Soc
Kim TW   +7 more
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G proteins

Trends in Biochemical Sciences, 1992
The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits.
J R, Hepler, A G, Gilman
openaire   +4 more sources

The role of G protein conformation in receptor–G protein selectivity

Nature Chemical Biology, 2023
G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear. Structural studies emphasize structural complementarity of GPCRs and nucleotide-free G proteins, but selectivity is likely to be determined by transient intermediate-state ...
Wonjo Jang   +4 more
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G Protein-Coupled Receptors and G Proteins

1997
G protein-coupled receptors (GPCRs) belong to a large class of membrane-spanning receptors. GPCRs function as antennae for external signals consisting of chemical ligands or photons (in the case of opsins). Once the external signal is received, it is transduced to a cytosolic G protein. Subsequently, the G protein itself becomes activated.
Paul H. J. Nederkoorn   +2 more
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Heterotrimeric G proteins

Current Opinion in Cell Biology, 1996
Over the past year, the thrust of work in the field of heterotrimeric G proteins has been primarily in the following areas: first, resolution of their three-dimensional structures by X-ray crystallography; second, elucidation of the effect of lipid modifications on the Galpha and Ggamma subunits; third, understanding the role of the Gbetagamma dimer in
H E, Hamm, A, Gilchrist
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